Distant metastases in phyllodes tumours of the breast: an overview

Koh, Valerie Cui Yun; Thike, Aye Aye; Tan, Puay Hoon

doi:10.1186/s41241-017-0028-6

Cited by 26 publications

(39 citation statements)

References 49 publications

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“…Distant recurrence was observed in some patients with borderline and malignant PTs, all of whom were treated with lumpectomy. This distribution was comparable to that in other studies [10][11][12][13]. Although stromal overgrowth has also been associated with the risk of disease recurrence, this factor was not included in our study [3,11].…”

Section: Discussionsupporting

confidence: 89%

Risk Factors for Disease Recurrence in Women With Phyllodes Tumors of the Breast in Southern Colombia: A Nine-Year Cohort Study

Olaya

Sanjuán

Luna

et al. 2020

Cureus

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Introduction Phyllodes tumors (PTs) are uncommon fibroepithelial breast tumors that occur in middle-aged women, and they tend to vary in biologic behavior. Surgical management is the standard therapy for the condition, but factors associated with recurrence remain unclear. The aim of this study was to evaluate clinical and surgical characteristics related to PT recurrences. Methods This retrospective cohort study included patients in southern Colombia who were diagnosed with PT and managed at a level I teaching and referral hospital over a nine-year period. Factors associated with recurrence were determined by Cox regression analysis. Results This study included 61 patients; their median age was 46 years [interquartile range (IQR): 39-55 years]. Pathologically, 37 tumors (60.7%) were classified as low-grade. The median tumor size was 7 cm (IQR: 4-11.5 cm). Thirty-nine (63.9%) patients underwent quadrantectomy. Nine patients (14.8%) experienced tumor recurrence, with the median time to recurrence being one year (IQR: 0.5-2 years). Distant metastasis was observed in four patients (6.6%) at a median of nine months (IQR: 0.4-2.5 years). Univariate analyses showed that patients with high-grade tumors [hazard ratio (HR): 2.90, p = 0.148] and those who underwent mastectomy (HR: 2.90, p = 0.460) were at higher risk of recurrence. Conclusion PT recurrence may be associated with biological features, the extent of local excision, tumor size, and negative margins. However, multicenter data are needed to confirm these findings.

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Section: Discussionsupporting

confidence: 89%

Risk Factors for Disease Recurrence in Women With Phyllodes Tumors of the Breast in Southern Colombia: A Nine-Year Cohort Study

Olaya

Sanjuán

Luna

et al. 2020

Cureus

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“…This is the first known case report of phyllodes tumor metastasizing to the skull. [5][6][7][8] Another unusual feature of this case is the long diseasefree interval of a relapsed metastatic solitary metastasis managed with surgery alone. Phyllodes tumors behave aggressively and typically follow the natural history of an aggressive sarcoma with a poor overall survival.…”

Section: Discussionmentioning

confidence: 99%

Phyllodes tumor with metastases to the skull managed with local excision: A case report

et al. 2019

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The behavior of phyllodes tumors is unpredictable and can behave as benign fibroadenomas or malignant neoplasms mimicking the course of aggressive sarcomas, characterized by distant metastases and a high short-term mortality. The malignant forms are treated with surgery and adjuvant chemotherapy, but often with poor outcomes. We examine the first reported case of an aggressive osteosarcoma subtype of phyllodes tumor that recurred in the skull after total mastectomy and adjuvant chemotherapy. The skull lesion was treated with excision, and the patient currently remains disease-free.

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“…Only less than 10% of these tumors grow larger than 10 cm and the largest reported case happens to be of 50 × 50 cm by Islam et al [ 5 ]. Approximately 85–90% of phyllodes tumors are benign and 10–15% are malignant [ 6 ] with metastasis in 10–26% cases of malignant phyllodes [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Malignant phyllodes tumor with metastases to lung, adrenal and brain: A rare case report

Khanal

Singh

Bhandari

et al. 2018

Annals of Medicine and Surgery

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BackgroundPhyllodes tumors are spectrum of tumors ranging from benign to malignant. Malignant spectrum pose a management challenge for clinicians due to high risks of recurrence and metastasis. Malignant phyllodes tumor with brain, lung and adrenal metastases at the same time is rare.Case presentationA 37 years-old unmarried female presented with an ulcerated huge lump in left breast with severe bleeding. Trucut biopsy showed necrosis with spindle cell proliferation with atypia for which she underwent modified radical mastectomy with final diagnosis of malignant phyllodes tumor. Three months after surgery, patient presented with headache, which on further evaluation showed masses in lung, right adrenal and brain.ConclusionWe presented a rare case of malignant phyllodes tumor with clinical, imaging and histological findings with metastases to multiple sites early in course and poor outcome of the patient despite margin negative resection.

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Distant metastases in phyllodes tumours of the breast: an overview

Cited by 26 publications

References 49 publications

Risk Factors for Disease Recurrence in Women With Phyllodes Tumors of the Breast in Southern Colombia: A Nine-Year Cohort Study

Risk Factors for Disease Recurrence in Women With Phyllodes Tumors of the Breast in Southern Colombia: A Nine-Year Cohort Study

Phyllodes tumor with metastases to the skull managed with local excision: A case report

Malignant phyllodes tumor with metastases to lung, adrenal and brain: A rare case report

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