Distension enterogenesis: increasing the size and function of small intestine

Mechanical Enterogenesis ‐ A Review

“…The enzymatic activity in the stretched segment was similar to that of controls as shown by the alkaline phosphatase and lactase activity. Histologically, the segment showed atrophic villi and hypertrophied smooth muscle [34]. This is the first in vivo study demonstrating application of the concept of distraction to enterogenesis.…”

“…The resultant intestine must function mechanically as well as biologically. Several reports have shown successful lengthening of intestine in both rats and pigs with preservation of the mechanical properties of intestinal smooth muscle as well as enzymatic and absorptive properties [11,[32][33][34]. Muscle contraction strength and rate of stretched rat jejunum were measured in organ baths with cholinergic stimulation [32].…”

“…In a study by Puapong et al using a rat model, a segment of jejunum was surgically isolated from the remaining small intestine [34]. The distal aspect of the segment was oversewn and the proximal aspect was sewn to the abdominal wall with a catheter placed inside.…”

“…Mechanical Enterogenesis -A Review Chen et al [36] 1997 Rabbit Saline dilation 126% Printz et al [37] 1997 Rabbit Serosal screw 100% Park et al [11] 2004 Rat Screw 210% Puapong et al [34] 2004 Rat Saline dilation 32% Safford et al [35] 2005 Rat Screw 149% Chang et al [10] 2006 Rat Screw 100% Mendoza et al [32] 2006 Rat Screw 130% Spencer et al [33] 2006 Pig Hydraulic piston 45% Luntz et al [39] 2006 Pig Hydraulic piston 69% Shekherdimian et al [40] 2009 Rat Spring 250%…”

Glucagon-Like Peptide 2 Increases Efficacy of Distraction Enterogenesis

“…This emerging area may provide a novel treatment for SBS (10)(11)(12). To address a better understanding of how distraction leads to intestinal growth, we developed a murine model of enterogenesis.…”