Distillation of Specialty Chemicals

Niggemann, Gerit; Rix, A.; Meier, Ralf

doi:10.1016/b978-0-12-386876-3.00007-7

Cited by 2 publications

(4 citation statements)

References 44 publications

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“…Once the best alternatives are chosen, the design of the extraction and purification of β-ionone is performed with Aspen Plus, with a COSMO-based model (extraction) and UNIFAC-Dortmund (purification) as the thermodynamic tools. The extraction process was simulated using a one plate liquid–liquid extraction unit and the purification process by distillation. , The complete process was optimized for each solvent. All the properties of the solvents along with their performance in the extraction/purification processes are assessed in order to select the best alternatives based on a multicriteria decision-making analysis.…”

Section: Introductionmentioning

confidence: 99%

“…The extraction process was simulated using a one plate liquid−liquid extraction unit and the purification process by distillation. 60,61 The complete process was optimized for each solvent. All the properties of the solvents along with their performance in the extraction/purification processes are assessed in order to select the best alternatives based on a multicriteria decision-making analysis.…”

Section: ■ Introductionmentioning

confidence: 99%

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In Situ Product Recovery of β-Ionone from a Fermentation Broth: Computational Solvent Selection and Process Design of Its Extraction and Purification

Arroyo-Avirama,

Carreño-Guzmán,

Lorenzo-Llanes

et al. 2023

ACS Sustainable Chem. Eng.

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Flavors and fragrances are important compounds used in the food, cosmetic, and pharmaceutical industries. They have an added value in the market when obtained through natural processes instead of synthetic routes. β-Ionone raises special interest if produced through a biotechnological process with genetically modified Sacharomyces cerevisiae, which is considered a natural production alternative. The main problem is that βionone is toxic to S. cerevisiae when its concentration increases in the fermentation broth. However, an in situ liquid−liquid extraction can alleviate the toxicity problem by removing the solute when it is produced. Thus, a screening of 6012 solvents for liquid−liquid extraction was performed by predicting the partition coefficient of β-ionone between an aqueous and an extracting organic phase using COSMO-RS. The best solvents for β-ionone extraction were selected after evaluating several parameters like solvent−water mutual solubility, solute extraction capacity, boiling temperature, thermophysical properties, and life cycle assessment of the solvent. The process was simulated and optimized in Aspen Plus V10 where in situ extraction was considered as a liquid−liquid extraction unit and the purification as two distillation towers in series. Then, a multicriteria decision-making analytical hierarchy process was performed based on the screening and simulation results with a subsequent sensitivity analysis. Finally, extracting solvents selected with the previous methodology were 2-methyl-2-butanol, 2-methyl-3-butene-2-ol, methyl isobutyl ketone, 1-pentanol, 1-octanol, myrcene, and n-decane, which were compared with the performance of dodecane, the benchmark extracting solvent used in the literature. Branched alcohols appear as a promising family of compounds for extracting β-ionone from aqueous phases.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

In Situ Product Recovery of β-Ionone from a Fermentation Broth: Computational Solvent Selection and Process Design of Its Extraction and Purification

Arroyo-Avirama,

Carreño-Guzmán,

Lorenzo-Llanes

et al. 2023

ACS Sustainable Chem. Eng.

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“…While several flexible and small-scale apparatuses have already been developed in the field of reaction technology, solutions for small scaled separation units are still of high interest [1]. As the production amounts of specialty chemicals are relatively small with the production processes being mostly complex, high purification and recovery are crucial for the utilization of the chemicals and for the economical operation of the production [2].…”

Section: Introductionmentioning

confidence: 99%

“…While the micro-distillation units offer a superior separation efficiency, the throughputs are considerably low at about a few milliliters per hour [3]. Other devices, like rotating packed beds, are able to deliver the required throughput but generate a significantly higher pressure drop than structured packings [4,5], which results in a higher thermal load of the mostly temperature-sensitive chemicals [2]. As packed columns show disadvantages like maldistribution following diminished efficiency, other technologies have to close this gap.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Operating Range of a Wetted‐Wall Column with a Packed Column for Distillation

Reitze

Grünewald

Riese

2020

Chemie Ingenieur Technik

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In this paper, a newly designed distillation column consisting of a wetted wall with a rectangular cross section is analyzed and compared with a conventional packed column with regard to the operating range of both apparatuses. As expected, the pressure drop is considerably lower in the wetted-wall column and, therefore, it offers a higher range of operation. However, in the wetted-wall column, the separation efficiency decreases rapidly with increasing F factors. This effect can be overcome by the serial connection of two wetted-wall columns.

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Distillation of Specialty Chemicals

Cited by 2 publications

References 44 publications

In Situ Product Recovery of β-Ionone from a Fermentation Broth: Computational Solvent Selection and Process Design of Its Extraction and Purification

In Situ Product Recovery of β-Ionone from a Fermentation Broth: Computational Solvent Selection and Process Design of Its Extraction and Purification

Comparison of the Operating Range of a Wetted‐Wall Column with a Packed Column for Distillation

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