Distinct adaptations of endocrine and cognitive functions may contribute to high variability in long-term weight loss outcome after bariatric surgery

Lammert, Mathis; Medawar, Evelyn; Hartmann, Hendrik; Grasser, Linda; Dietrich, Arne; Fenske, Wiebke; Horstmann, Annette

doi:10.1016/j.physbeh.2023.114279

Cited by 4 publications

(1 citation statement)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BS is considered a successful intervention when the outcome of the surgery is the loss of ≥50% of the percentage of excess weight (%EWL), which is related to decreasing the risk of developing obesity-related diseases [5]. This index is widely used, even in recent studies [6][7][8][9][10], including reviews on this topic [11][12][13], to analyse the efficacy of bariatric surgery on weight loss. However, there is still a high percentage of failure (up to 50%), since the efficacy of the procedure depends on many factors, such as type of procedure, age, sex and ethnic background [14].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Depressive Symptoms, Quality of Life and miRNAs 8 Years after Bariatric Surgery

Mela,

Agüera,

Alvarez-Bermudez

et al. 2023

Nutrients

View full text Add to dashboard Cite

(1) Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. (2) Methods: A total of 53 patients with class III obesity who underwent BS, and then classified into “good responders” and “non-responders” depending on the percentage of excess weight lost (%EWL) 8 years after BS (%EWL ≥ 50% and %EWL < 50%, respectively), were included. Basal serum miRNAs and different proteins were analysed, and patients completed tests to evaluate QoL/depressive symptomatology at 8 years after BS. (3) Results: The good responders group showed higher scores on SF-36 scales of physical functioning, role functioning—physical, role functioning—emotional, body pain and global general health compared with the non-responders. The expression of hsa-miR-101-3p, hsa-miR-15a-5p, hsa-miR-29c-3p, hsa-miR-144-3p and hsa-miR-19b-3p were lower in non-responders. Hsa-miR-19b-3p was the variable associated with the response to BS in a logistic regression model. (4) Conclusions: The mental health of patients after BS is limited by the success of the intervention. In addition, the expression of basal serum miRNAs related to depression/anxiety could predict the success of BS.

show abstract