2006
DOI: 10.1128/aac.50.1.324-331.2006
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Distinct Antifungal Mechanisms: β-Defensins RequireCandida albicansSsa1 Protein, while Trk1p Mediates Activity of Cysteine-Free Cationic Peptides

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Cited by 86 publications
(84 citation statements)
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“…This observation suggested that the two peptides shared a binding protein on the fungal surface. When neutrophil defensin 1 was incubated with wildtype, hsp70⌬/⌬, and ssa2⌬/⌬ strains, the mutant strains remained susceptible to killing (401). This observation is at odds with the first observation of competition for the binding site.…”
Section: Mp65pcontrasting
confidence: 46%
“…This observation suggested that the two peptides shared a binding protein on the fungal surface. When neutrophil defensin 1 was incubated with wildtype, hsp70⌬/⌬, and ssa2⌬/⌬ strains, the mutant strains remained susceptible to killing (401). This observation is at odds with the first observation of competition for the binding site.…”
Section: Mp65pcontrasting
confidence: 46%
“…The antifungal protein from tobacco, osmotin, for example, requires the presence of particular mannoproteins in the cell wall of S. cerevisiae for its activity (21). The cell wall of C. albicans also contains proteins that are essential for the internalization and antifungal activity of the human protein histatin 5 (22,23). This suggests that the cell wall may play an essential role in the activity of antifungal proteins.…”
Section: Discussionmentioning
confidence: 99%
“…Gene profiling of oral mucosal tissue showed strong induction of Th17 signature genes, including beta defensin-3 and CXC chemokines. hBD-3 has candidacidal activity in vitro (Vylkova et al, 2006), and saliva from wild-type mice, but not IL-17Ra -/-mice, has candidacidal activity, indicating that IL-17 also controls C. albicans proliferation by promoting secretion of antimicrobial peptides (Conti et al, 2009). However, more work is needed to understand whether Th17 responses also govern the response to oral candidiasis in humans, because it is unclear whether mouse and human diseases have the same etiology.…”
Section: Oral Mucosal T-cell Responses To C Albicansmentioning
confidence: 99%