2022
DOI: 10.1093/nargab/lqac086
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Distinct chromosomal “niches” in the genome ofSaccharomyces cerevisiaeprovide the background for genomic innovation and shape the fate of gene duplicates

Abstract: Nearly one third of Saccharomyces cerevisiae protein coding sequences correspond to duplicate genes, equally split between small-scale duplicates (SSD) and whole-genome duplicates (WGD). While duplicate genes have distinct properties compared to singletons, to date, there has been no systematic analysis of their positional preferences. In this work, we show that SSD and WGD genes are organized in distinct gene clusters that occupy different genomic regions, with SSD being more peripheral and WGD more centrally… Show more

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Cited by 2 publications
(1 citation statement)
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“…This search was conducted with BLASTp 32 using an E-value cut-off of 0.001 and the -max_target_seqs flag set to 1000. The results of the similarity searches were processed as in 36 : For each gene, we first obtained the list of all fungal species with a significant similarity match. Phylogenetic age of each gene was then calculated as the most recent common ancestor of all species with a match.…”
Section: Methodsmentioning
confidence: 99%
“…This search was conducted with BLASTp 32 using an E-value cut-off of 0.001 and the -max_target_seqs flag set to 1000. The results of the similarity searches were processed as in 36 : For each gene, we first obtained the list of all fungal species with a significant similarity match. Phylogenetic age of each gene was then calculated as the most recent common ancestor of all species with a match.…”
Section: Methodsmentioning
confidence: 99%