Distinct Circulating Antibodies Demonstrated in Tuberculous Patients, Correlation Between Changes in the Antibody Content of the Serum, and Clinical Evolution

Favez, G

doi:10.1111/j.1749-6632.1968.tb16702.x

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…One of these roles is the nonspecific stimulation of macrophages in the local lesion (60,61,173). Another is the production of specific antibodies to the phospholipids and polysaccharides of the bacillus (18,54,112,113,122,152,172). However, the major role of these lipopolysaccharides is probably to act as a nonspecific adjuvant (107,128,168) for the establishment of delayed hypersensitivity to tuberculoprotein.…”

Section: General Aspects Of Cellular Hypersensi-tivrry and Cellular Imentioning

confidence: 99%

Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes.

Dannenberg¹

1968

Bacteriological Reviews

113

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This article makes no attempt to review the literature in a complete fashion, but relies on articles which do so. References to such articles are printed in italic type. In this review, cellular hypersensitivity, cellular allergy, and delayed hypersensitivity are used interchangeably; and macrophage activation is used synonymously with macrophage maturation and macrophage differentiation. Although macrophages frequently proliferate during the activating process, activation can occur without proliferation. These two terms are therefore used independently. with current knowledge. These assumptions are then used to explain the known facts concerning the pathogenesis of tuberculosis. Finally, the relative importance of local and systemic aspects of cellular immunity is discussed. Nature and Effects of Cellular Hypersensitivity In tuberculosis, cellular hypersensitivity, the delayed type of allergy, may be defined as an immunological state in which lymphocytes and macrophages are directly or indirectly sensitive to tuberculin. As a result of this sensitivity, tuberculin in the appropriate low concentration will activate macrophages, i.e., cause the production of new lysosomes and other organelles as well 85

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Section: General Aspects Of Cellular Hypersensi-tivrry and Cellular Imentioning

confidence: 99%

Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes.

Dannenberg¹

1968

Bacteriological Reviews

113

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A longitudinal study of antibody titres to antigen 6 in patients with bone and joint tuberculosis

Lau

Leong

Stroebel

1983

International Orthopaedics

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Thirteen patients with active bone and joint tuberculosis were investigated to determine their antibody response to Antigen 6 of Mycobacterium tuberculosis during and after treatment. The antibody titre was found to be most helpful in diagnosis and in assessing the activity of the disease after treatment was completed. There is great individual variation of the antibody level, so the use of this serological test for monitoring the response to treatment requires further investigation in a larger group of patients.

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Serologic Diagnosis of Bone and Joint Tuberculosis by an Enzyme-Linked Immunosorbent Assay

Stroebel¹,

Daniel²,

Lau³

et al. 1982

The Journal of Infectious Diseases

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Sera from patients receiving treatment for active bone and joint tuberculosis and sera from patients with inactive bone and joint tuberculosis were examined by an enzyme-linked immunosorbent assay for antibody to antigen 6, a homogeneous protein prepared from Mycobacterium tuberculosis strain H37Ra by immunosorbent affinity chromatography. Sera from 21 control subjects had a geometric mean titer of 1:6 with no difference between tuberculin purified protein derivative-positive and -negative patients. Sera from 20 patients with inactive disease had a geometric mean titer of 1:19. Fifteen patients receiving treatment for M. tuberculosis infection had a geometric mean titer of 1:179, which is significantly different from the geometric mean titers of both of the patients with inactive tuberculosis (P less than 0.001) and the control subjects (P less than 0.001). At a cut-off titer of 1:32, the sensitivity of the assay is 94% and the specificity for the control subjects and patients with inactive disease was 100%.

show abstract

Distinct Circulating Antibodies Demonstrated in Tuberculous Patients, Correlation Between Changes in the Antibody Content of the Serum, and Clinical Evolution

Cited by 3 publications

References 2 publications

Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes.

Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes.

A longitudinal study of antibody titres to antigen 6 in patients with bone and joint tuberculosis

Serologic Diagnosis of Bone and Joint Tuberculosis by an Enzyme-Linked Immunosorbent Assay

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