Distinct clinicopathologic characteristics of lung mucinous adenocarcinoma with KRAS mutation

Ichinokawa, Hideomi; Ishii, Genichiro; Nagai, Kanji; Kawase, Akikazu; Yoshida, Junji; Nishimura, Mitsuyo; Hishida, Tomoyuki; Ogasawara, Naomi; Tsuchihara, Katsuya; Ochiai, Atsushi

doi:10.1016/j.humpath.2013.05.026

Cited by 45 publications

(32 citation statements)

References 26 publications

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“…In Hung's cohort [5], no significant difference was seen in PRS between patients received re-operation and those who had chemotherapy and/or radiotherapy, but the conclusion needed further investigation. EGFR mutations were less likely to detect in solid predominant patients, which predicts primary resistance to tyrosine kinase inhibitors (TKIs) [24, 25]. This may another reason for the poor PRS among patients with solid predominant pattern.…”

Section: Discussionmentioning

confidence: 99%

Solid predominant histologic subtype and early recurrence predict poor postrecurrence survival in patients with stage I lung adenocarcinoma

et al. 2016

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IntroductionThis study investigated the correlation between histologic predominant pattern and postrecurrence survival (PRS), and identified the clinicopathologic factors influencing PRS in patients with completely resected stage I lung adenocarcinoma.MethodsA total of 136 stage I lung adenocarcinoma patients who experienced tumor recurrence after completely resection were included in this study. To analysis the association between histologic predominant pattern and PRS, invasive adenocarcinomas with mixed histologic components were divided into 2 groups: solid and nonsolid group (including lepidic, acinar, papillary, micropapillary) based on the histologic predominant pattern. PRS was analyzed to identify the prognostic predictors using the Kaplan-Meier approach and multivariable Cox models.ResultsFor all stage I invasive adenocarcinoma patients, the majority of postsurgical recurrences occurred within 2 years. Patients with solid predominant histological pattern were associated with unfavorable PRS (HR, 2.40; 95%CI 1.13-5.08, p=.022). There was a significant difference for poor PRS for patients who diagnosed tumor recurrence shorter than 12 months after surgery (HR, 2.34; 95%CI 1.12-4.90, p=.024). Extrathoracic metastasis was associated with poor media PRS in univariable analysis (p =.011), however, there was no significant PRS difference in multivariable analysis (HR, 1.56; 95%CI 0.65-3.73, p=.322) compared with intrathoracic metastasis.ConclusionsSolid predominant histologic subtype and recurrence free interval less than 12 months predict worse PRS in patients with stage I lung adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Solid predominant histologic subtype and early recurrence predict poor postrecurrence survival in patients with stage I lung adenocarcinoma

et al. 2016

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“…Gerektiği zaman bu panele müsin boyası eklenebilir (8-10). (18,19). Son yıllarda, ErbB2/ErbB3 yolağındaki regülasyon bozukluğu, özellikle KRAS mutasyonu pozitif müsinöz patern gösteren AK'larda yeni bir onkojenik özellik olarak gösterilmiştir (20).…”

Section: Solid Adenokarsinomunclassified

Changes in the classification of lung adenocarcinoma

Gümürdülü¹,

Nart²

2019

JCurrPath

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“…In an immunohistochemical analysis, IMA was reported to express HNF4a . Furthermore, this tumor exhibits a very strong correlation with the KRAS mutation, whereas non‐mucinous adenocarcinoma is more likely to have the epidermal growth factor receptor (EGFR) mutation …”

Section: Introductionmentioning

confidence: 99%

“…1,2 IMA is defined as adenocarcinoma that is characterized by a goblet or columnar cell morphology with abundant intracytoplasmic mucin. 2 Although the clinical, pathological, and genetic characteristics of IMA have been revealed in recent reports, [3][4][5][6][7][8][9][10][11][12][13] the prognosis and prognostic factors have not yet been clarified, due to its rare incidence as it accounts for only 5% of all lung adenocarcinomas. 2 In previous studies, IMA had distinct clinical, pathological, and genetic differences from non-mucinous adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

“…13 Furthermore, this tumor exhibits a very strong correlation with the KRAS mutation, whereas non-mucinous adenocarcinoma is more likely to have the epidermal growth factor receptor (EGFR) mutation. 12 The aggressiveness of a tumor depends on its microenvironment, which is composed not of only cancer cells, but also of stromal cells, including cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs). However, the clinicopathological importance of the presence of tumor-promoting CAFs and TAMs has only been investigated in non-mucinous adenocarcinoma cases.…”

Section: Introductionmentioning

confidence: 99%

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Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung

Oki

Aokage

Ueda

et al. 2019

Pathology International

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Invasive mucinous adenocarcinoma (IMA) is a newly classified variant of lung adenocarcinoma. The aim of this study was to examine the correlation between the proportion of goblet cells and the clinicopathological characteristics of IMA. Ninety‐nine patients with stage I IMA were included in this study. We estimated prognostic impact of goblet cell proportion. We classified them into two groups: the cases with a high goblet cell proportion (HGP, goblet cell proportion ≥80%) and the cases with a low goblet cell proportion (LGP, goblet cell proportion ≤30%), and compared the expression levels of five cancer progression markers and the number of tumor‐promoting stromal cells between the two groups. Univariate and multivariate analysis revealed that the goblet cell proportion was a prognostic factor for recurrence free survival (P < 0.01) and overall survival (P = 0.01). The expression levels of the cancer stem cell‐related marker, ALDH‐1, and proliferation‐related marker, geminin were significantly higher in the LGP group than in the HGP group. CD204+ tumor‐associated macrophages were significantly more in the LGP stroma than the HGP stroma. Our current study indicated that the proportion of goblet cells was correlated with the malignant potential in surgically resected IMA.

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Distinct clinicopathologic characteristics of lung mucinous adenocarcinoma with KRAS mutation

Cited by 45 publications

References 26 publications

Solid predominant histologic subtype and early recurrence predict poor postrecurrence survival in patients with stage I lung adenocarcinoma

Solid predominant histologic subtype and early recurrence predict poor postrecurrence survival in patients with stage I lung adenocarcinoma

Changes in the classification of lung adenocarcinoma

Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung

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