Distinct correlations of vasopressin release within the lateral septum and the bed nucleus of the stria terminalis with the display of intermale aggression

Veenema, Alexa H.; Beiderbeck, Daniela I.; Lukas, Michael; Neumann, Inga D.

doi:10.1016/j.yhbeh.2010.03.006

Cited by 157 publications

(130 citation statements)

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“…Secondly, and more importantly for the present study, (Ferris and Potegal, 1988 (Beiderbeck et al, 2007), despite the fact that vasopressin 56 release in the same brain area strongly promoted aggression 57 in rats not selected for anxiety (Veenema et al, 2010). In a 58 recent study, plasma levels of vasopressin showed a positive 59 correlation with aggressiveness in female rats repeatedly 60 submitted to stressors in puberty, while a negative correla-61 tion was seen in controls (Cordero et al, 2013).…”

mentioning

confidence: 51%

“…Aggressive interactions increase vasopressin release in par-9 ticular brain regions (Compaan et al, 1993;Beiderbeck 10 et al, 2007;Gobrogge et al, 2009;Neumann et al, 2010; 11 Veenema et al, 2010;Bosch, 2013;Cordero et al, 2013), (Veenema et al, 2010;Kelly and Goodson, 36 2013). Secondly, and more importantly for the present study, (Ferris and Potegal, 1988 (Beiderbeck et al, 2007), despite the fact that vasopressin 56 release in the same brain area strongly promoted aggression 57 in rats not selected for anxiety (Veenema et al, 2010).…”

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confidence: 99%

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The effects of vasopressin deficiency on aggression and impulsiveness in male and female rats

Fodor

Barsvári

Aliczki

et al. 2014

Psychoneuroendocrinology

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confidence: 51%

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confidence: 99%

The effects of vasopressin deficiency on aggression and impulsiveness in male and female rats

Fodor

Barsvári

Aliczki

et al. 2014

Psychoneuroendocrinology

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“…For example, a positive correlation between aggressive behavior and vasopressin levels in the cerebrospinal fluid have been reported for rats (Haller et al, 1996) and violent humans (men and premenopausal women) with personality disorders (Coccaro et al, 1998). In male rats, distinct correlations were found between vasopressin release in the lateral septum and bed nucleus of the stria terminalis and aggressive behavior displays (Veenema et al, 2010). Furthermore, AVP treatment increases brain activity in aggression-related areas (Ferris, 2008), and conversely, antagonists of AVP receptors 1A were found to reduce aggression while simultaneously suppressing the pattern of brain activation caused by an intruder (Ferris, 2008).…”

Section: Discussionmentioning

confidence: 98%

Long-term programming of enhanced aggression by peripuberty stress in female rats

Cordero

Ansermet

Sandi

2013

Psychoneuroendocrinology

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Summary Human literature has linked adverse early life experiences with an increased risk to develop violent behaviors in both boys and girls. We have previously shown that male rats submitted to stress during the peripuberty period display as adults abnormal aggressive behavior against both male intruders and female partners. In the present study, we examined whether the same stress protocol would affect the development of aggressive behaviors in female rats. We evaluated the behavior of these peripuberty stressed female rats when confronted, at adulthood, with either female or male intruders, and during their cohabitation with male partners. Given that estrus cycle influences mood and aggressive behaviors, female aggressive behavior was assessed at different estrus cycle phases: estrus and diestrus, and during pregnancy and lactancy. Additionally, we evaluated postpartum plasma levels of vasopressin, oxytocin and corticosterone, hormones associated with aggression and the regulation of social behavior. Compared to control females, females submitted to stressful events during puberty exhibited higher and more sustained rates of aggression during adulthood independently on the estrus cycle or the sex of the intruder, and they had higher levels of plasma vasopressin. Significant correlations between plasma levels of vasopressin and corticosterone and aggressive behavior were also found. Strikingly, our results showed opposite intragroup correlations suggesting a different role of these hormones on aggression depending on life experiences. We provide here an animal model, devoid of cultural influences strongly supporting a role for biological factors in the development of aggressive behaviors following exposure to stressful events at puberty in females. #

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“…OXT plays key regulatory roles in affiliative and social behaviors as has been revealed by substantial studies in rodents [1][2][3] and other species [4,5], including humans [6]. Similarly, AVP is also involved in the regulation of social behaviors including social preference [7], social memory [8], social bonding [9], and aggression [10].…”

Section: Introductionmentioning

confidence: 96%

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

Zhang

Dai

et al. 2016

Neurosci. Bull.

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Autism spectrum disorder (ASD) is defined by impairments of social interaction and the presence of obsessive behaviors. The ''twin'' nonapeptides oxytocin (OXT) and arginine-vasopressin (AVP) are known to play regulatory roles in social behaviors. However, the plasma levels and behavioral relevance of OXT and AVP in children with ASD have seldom been investigated. It is also unknown whether their mothers have abnormal plasma peptide levels. Here, using well-established methods of neuropeptide measurement and a relatively large sample size, we determined the plasma levels of the two neuropeptides in 85 normal children, 84 children with ASD, and 31 mothers from each group of children. As expected, children with ASD had lower plasma OXT levels than gender-matched controls (P = 0.028). No such difference was found for plasma AVP concentrations. Correlation analysis showed that ASD children with higher plasma OXT concentrations tended to have less impairment of verbal communication (Rho = -0.22, P = 0.076), while those with higher plasma AVP levels tended to have lower levels of repetitive use of objects (Rho = -0.231, P = 0.079). Unlike the findings in children, maternal plasma OXT levels showed no group difference. However, plasma AVP levels in the mothers of ASD children tended to be lower than in the mothers of normal children (P = 0.072). In conclusion, our results suggest that the OXT system is dysregulated in children with ASD, and that OXT and AVP levels in plasma seem to be associated with specific autistic symptoms. The plasma levels of OXT or AVP in mothers and their ASD children did not seem to change in the same direction.

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Distinct correlations of vasopressin release within the lateral septum and the bed nucleus of the stria terminalis with the display of intermale aggression

Cited by 157 publications

References 59 publications

The effects of vasopressin deficiency on aggression and impulsiveness in male and female rats

The effects of vasopressin deficiency on aggression and impulsiveness in male and female rats

Long-term programming of enhanced aggression by peripuberty stress in female rats

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

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