Distinct Diet-Microbiota-Metabolism Interactions in Overweight and Obese Pregnant Women: a Metagenomics Approach

Lotankar, Mrunalini; Mokkala, Kati; Houttu, Noora; Koivuniemi, Ella; Sørensen, Nikolaj; Nielsen, Henrik Bjørn; Munukka, Eveliina; Lahti, Leo; Laitinen, Kirsi

doi:10.1128/spectrum.00893-21

Cited by 7 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the overall gut microbiota diversity did not differ in individuals consuming higher inflammatory diets. While distinct patterns of beta diversity composition in pregnant individuals with better diet quality have been previously reported (61, 62), recent microbiome-pregnancy cohorts have not identified alterations in beta diversity by diet quality (63,64), supporting our study observations. At the taxonomic level, several ASVs varied with dietary inflammatory potential.…”

Section: Discussionsupporting

confidence: 90%

Inflammatory dietary potential is associated with vitamin depletion and gut microbial dysbiosis in early pregnancy

Alvernaz,

Wenzel,

Nagelli

et al. 2023

Preprint

View full text Add to dashboard Cite

BackgroundPregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter host inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microbiota dysbiosis, including gestational diabetes mellitus, preeclampsia, preterm birth, and mood disorders. However, the effects of high inflammatory diets on the gut microbiota during pregnancy has yet to be fully explored.ObjectiveTo use a systems-based approach to characterize associations among dietary inflammatory potential, a measure of diet quality, and the gut microbiome during pregnancy.MethodsForty-nine pregnant persons were recruited prior to 16 weeks of gestation. Participants completed a food frequency questionnaire (FFQ) and provided fecal samples. Dietary inflammatory potential was assessed using the Dietary Inflammatory Index (DII) from FFQ data. Fecal samples were analyzed using 16S rRNA amplicon sequencing. Differential taxa abundance with respect to DII score were identified, and microbial metabolic potential was predicted using PICRUSt2.ResultsInflammatory diets were associated with decreased vitamin and mineral intake and dysbiotic gut microbiome structure and metabolism. Gut microbial compositional differences revealed a decrease in short chain fatty acid producers such as g_Faecalibacterium,upregulation of vitamin B12 synthesis, methylglyoxal detoxification, galactose metabolism and multi drug efflux systems in pregnant individuals with increased DII scores.ConclusionsDietary inflammatory potential was associated with depletion of vitamins & minerals and gut microbiota metabolic dysregulation.

show abstract

Section: Discussionsupporting

confidence: 90%

Inflammatory dietary potential is associated with vitamin depletion and gut microbial dysbiosis in early pregnancy

Alvernaz,

Wenzel,

Nagelli

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…All DII scores were within the normal limits specified by the DII score authors [29]. While distinct patterns of beta diversity composition in pregnant individuals with better diet quality have been previously reported [61,62], recent microbiome-pregnancy cohorts have not identified alterations in beta diversity based on diet quality [63,64], supporting our study observations. At the taxonomic level, several ASVs varied with dietary inflammatory potential.…”

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 59%

Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy

Alvernaz,

Wenzel,

Nagelli

et al. 2024

Nutrients

View full text Add to dashboard Cite

Pregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter the host immune system to promote inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microbial dysbiosis, including gestational diabetes mellitus, pre-eclampsia, preterm birth, and mood disorders. However, the effects of high-inflammatory diets on the gut microbiota during pregnancy have yet to be fully explored. We aimed to address this gap using a system-based approach to characterize associations among dietary inflammatory potential, a measure of diet quality, and the gut microbiome during pregnancy. Forty-seven pregnant persons were recruited prior to 16 weeks of gestation. Participants completed a food frequency questionnaire (FFQ) and provided fecal samples. Dietary inflammatory potential was assessed using the Dietary Inflammatory Index (DII) from the FFQ data. Fecal samples were analyzed using 16S rRNA amplicon sequencing. Differential taxon abundances with respect to the DII score were identified, and the microbial metabolic potential was predicted using PICRUSt2. Inflammatory diets were associated with decreased vitamin and mineral intake and a dysbiotic gut microbiota structure and predicted metabolism. Gut microbial compositional differences revealed a decrease in short-chain fatty acid producers such as Faecalibacterium, and an increase in predicted vitamin B12 synthesis, methylglyoxal detoxification, galactose metabolism, and multidrug efflux systems in pregnant individuals with increased DII scores. Dietary inflammatory potential was associated with a reduction in the consumption of vitamins and minerals and predicted gut microbiota metabolic dysregulation.

show abstract

“…In non‐pregnant populations, the healthy eating index (adherence to the US dietary guidelines) and the MDS have been correlated with microbiota diversity and composition 63 . In a previous study, diet quality in women with obesity, but not women classified as overweight, was found to be associated with diversity and gut microbiota composition in early pregnancy (<18 weeks) 64 . Ruebel et al reported positive associations between dietary components and genus‐level abundances when dietary intakes and genus level abundances were averaged over the course of pregnancy 65 .…”

Section: Discussionmentioning

confidence: 99%

“…63 In a previous study, diet quality in women with obesity, but not women classified as overweight, was found to be associated with diversity and gut microbiota composition in early pregnancy (<18 weeks). 64 Ruebel et al reported positive associations between dietary components and genus-level abundances when dietary intakes and genus level abundances were averaged over the course of pregnancy. 65 There are limited data on the effect of dietary intake on the human microbiota in the third trimester of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiome composition is similar between pregnant women with excess body fat with healthy and less healthy dietary intake patterns

O'Connor

Hodge

et al. 2023

J Human Nutrition Diet

View full text Add to dashboard Cite

Background: Dietary composition influences the composition of the gut microbiota in healthy adults. Little is known about the effect of dietary patterns on gut microbiota composition in pregnancy. This crosssectional study aimed to investigate the associations between two diet quality scores adapted from the Australian Recommended Food Score (ARFS) and the Mediterranean Dietary Score (MDS) with the composition of the gut microbiota in pregnant women with excess body fat at 28 weeks' gestation. Methods: Women from the Study of Probiotics IN Gestational diabetes (SPRING) who had completed a food frequency questionnaire (FFQ; n = 395) were classified according to tertiles of ARFS and the MDS. Higher dietary pattern scores in both the ARFS and the MDS represent better diet quality. Gut microbiota composition was assessed using 16S rRNA gene amplicon sequencing and analysed using MicrobiomeAnalyst in a subset of 196 women with faecal samples. Results: No significant difference was found in alpha or beta diversity. A higher ARFS was associated with a higher abundance of Ruminococcus and lower abundance of Akkermansia, whereas a higher MDS was associated with a higher abundance of Ruminococcus and Butyricicoccus, though these changes disappeared after correction for multiple testing. Conclusion: These results suggest that dietary patterns defined by the ARFS and MDS were not associated with gut microbiota composition in pregnant women classified as overweight and obese at 28 weeks' gestation within this study.

show abstract

Distinct Diet-Microbiota-Metabolism Interactions in Overweight and Obese Pregnant Women: a Metagenomics Approach

Cited by 7 publications

References 34 publications

Inflammatory dietary potential is associated with vitamin depletion and gut microbial dysbiosis in early pregnancy

Inflammatory dietary potential is associated with vitamin depletion and gut microbial dysbiosis in early pregnancy

Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy

Gut microbiome composition is similar between pregnant women with excess body fat with healthy and less healthy dietary intake patterns

Contact Info

Product

Resources

About