Distinct Expression Patterns of Genes Coding for Biological Response Modifiers Involved in Inflammatory Responses and Development of Fibrosis in Chronic Hepatitis C: Upregulation of SMAD-6 and MMP-8 and Downregulation of CAV-1, CTGF, CEBPB, PLG, TIMP-3, MMP-1, ITGA-1, ITGA-2 and LOX

Radmanić, Leona; Korać, Petra; Gorenec, Lana; Simicic, Petra; Bodulić, Kristian; Vince, Adriana; Lepej, Snježana Židovec

doi:10.3390/medicina58121734

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Not only that, RAF1 also contributes to vascular endothelium homeostasis and cardiac remodeling after myocardial infarction [21]. CEBPB plays a critical role in the regulation of immune and in ammatory responses [22]. Several studies have demonstrated that CEBPB is involved in the pathogenesis of myocardial infarction [23].…”

Section: Discussionmentioning

confidence: 99%

Identification of Biomarkers for Acute Myocardial Infarction based on Cell Senescence Genes and Machine Learning

Mao

Yang

et al. 2023

Preprint

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Background This study aims to identify senescence-related biomarkers for ST-elevation myocardial infarction (STEMI) prognosis.Methods RNA expression data for STEMI samples and controls were obtained from the Gene Expression Omnibus (GEO) database, and cellular senescence genes were acquired from CellAge database. Differential and overlap analyses were used to identify differentially expressed cellular senescence-related genes (DE-SRGs) in STEMI samples. DE-SRGs were further analyzed using plotting receiver operator characteristic (ROC) curves and machine learning algorithms. Gene Set Enrichment Analysis (GSEA) was employed on each biomarker. Immune related analyses, competing endogenous RNA (ceRNA) construction, and target drug prediction were performed on biomarkers.Results This study identified 7 DE-SRGs for STEMI prognosis. GSEA results showed enriched pathways, including ribosome, autophagy, allograft rejection, and autoimmune thyroid disease. Further, T cells CD4 memory resting, T cells gamma delta, Monocytes and Neutrophils represented significantly different proportions between STEMI samples and controls. In addition, CEBPB was positively correlated with Monocytes and Neutrophils, but negatively correlated with T cells CD8. A ceRNA network was established and eight FDA-approved drugs were predicted.Conclusion This study identified 7 cellular senescence-related biomarkers, which could lay a foundation for further study of the relationship between STEMI and cellular senescence.

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Section: Discussionmentioning

confidence: 99%

Identification of Biomarkers for Acute Myocardial Infarction based on Cell Senescence Genes and Machine Learning

Mao

Yang

et al. 2023

Preprint

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“…Loss of MMP‐8 impaired inflammatory response and increased the risk of skin tumors in mice (Balbín et al, 2003), but its effect on liver fibrosis is unknown. On the other hand, overexpression of MMP‐8 reduced fibrosis and induced breakdown of fibrous tissues in a rat model of live fibrosis induced by CCl 4 or BDL (Harty et al, 2005; Radmanić et al, 2022). Therefore, the increased expression of MMP‐8 in alcoholic cirrhosis may be a self‐defense mechanism to alleviate liver fibrosis, and MMP‐8 may be a promising therapeutic target to reduce the risk of cancer and liver fibrosis.…”

Section: Pathophysiology Of Liver Fibrosismentioning

confidence: 99%

Extracellular matrix turnover: phytochemicals target and modulate the dual role of matrix metalloproteinases (MMPs) in liver fibrosis

Sabir

Zhang

2023

Phytotherapy Research

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Extracellular matrix (ECM) resolution by matrix metalloproteinases (MMPs) is a well‐documented mechanism. MMPs play a dual and complex role in modulating ECM degradation at different stages of liver fibrosis, depending on the timing and levels of their expression. Increased MMP‐1 combats disease progression by cleaving the fibrillar ECM. Activated hepatic stellate cells (HSCs) increase expression of MMP‐2, ‐9, and ‐13 in different chemicals‐induced animal models, which may alleviate or worsen disease progression based on animal models and the stage of liver fibrosis. In the early stage, elevated expression of certain MMPs may damage surrounding tissue and activate HSCs, promoting fibrosis progression. At the later stage, downregulation of MMPs can facilitate ECM accumulation and disease progression. A number of phytochemicals modulate MMP activity and ECM turnover, alleviating disease progression. However, the effects of phytochemicals on the expression of different MMPs are variable and may depend on the disease models and stage, and the dosage, timing and duration of phytochemicals used in each study. Here, we review the most recent advances in the role of MMPs in the effects of phytochemicals on liver fibrogenesis, which indicates that further studies are warranted to confirm and define the potential clinical efficacy of these phytochemicals.

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Distinct Expression Patterns of Genes Coding for Biological Response Modifiers Involved in Inflammatory Responses and Development of Fibrosis in Chronic Hepatitis C: Upregulation of SMAD-6 and MMP-8 and Downregulation of CAV-1, CTGF, CEBPB, PLG, TIMP-3, MMP-1, ITGA-1, ITGA-2 and LOX

Cited by 2 publications

References 36 publications

Identification of Biomarkers for Acute Myocardial Infarction based on Cell Senescence Genes and Machine Learning

Identification of Biomarkers for Acute Myocardial Infarction based on Cell Senescence Genes and Machine Learning

Extracellular matrix turnover: phytochemicals target and modulate the dual role of matrix metalloproteinases (MMPs) in liver fibrosis

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