Distinct features of the portalhypertensive syndrome in patients with advanced chronic liver disease due to non-alcoholic steatohepatitis

Paternostro, Rafael; Kwanten, Wilhelmus J.; Becker, Jeannette; Hofer, Benedikt; Panagl, Vera; Schiffke, Helena; Vonghia, Luisa; Vanwolleghem, Thomas; Bagdadi, Ali; Simbrunner, Benedikt; Semmler, Georg; Reiberger, Thomas; Scheiner, Bernhard; Bucsics, Theresa; Bauer, David JM; Eigenbauer, Ernst; Trauner, Michael; Mandorfer, Mattias; Francque, Sven; Reiberger, T

doi:10.1016/s0168-8278(20)31957-7

Cited by 2 publications

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“…Furthermore, the cumulative incidence of hepatic decompensation after 5 years increased to 24% in those with subclinical portal hypertension, 39% in those with CSPH, and 50% in those severe portal hypertension (HVPG≥16 mmHg). 41 Thus, despite the nomenclature, the presence of subclinical portal hypertension in ≥F3 NAFLD is clinically significant, as nearly a quarter of these patients would be expected to decompensate over 5 years.…”

Section: Portal Hypertension Begins In Precirrhotic Nafld and May Pre...mentioning

confidence: 99%

“…[30][31][32] Clinical studies provide additional evidence for the development of portal hypertension in precirrhotic NAFLD (Table 1). [36][37][38][39][40][41] When HVPG was measured in a study of 50 patients with biopsy-proven NAFLD, portal hypertension (HVPG>5 mmHg) was confirmed in 22% of patients with ≤F2 fibrosis. The severity of steatosis was the only histological parameter that correlated with the degree of portal hypertension.…”

Section: Portal Hypertension Begins In Precirrhotic Nafld and May Pre...mentioning

confidence: 99%

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Portal Hypertension in Nonalcoholic Fatty Liver Disease: Challenges and Paradigms

Mitten¹,

Portincasa²,

Baffy³

2023

J Clin Transl Hepatol

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Portal hypertension in cirrhosis is defined as an increase in the portal pressure gradient (PPG) between the portal and hepatic veins and is traditionally estimated by the hepatic venous pressure gradient (HVPG), which is the difference in pressure between the free-floating and wedged positions of a balloon catheter in the hepatic vein. By convention, HVPG≥10 mmHg indicates clinically significant portal hypertension, which is associated with adverse clinical outcomes. Nonalcoholic fatty liver disease (NAFLD) is a common disorder with a heterogeneous clinical course, which includes the development of portal hypertension. There is increasing evidence that portal hypertension in NAFLD deserves special considerations. First, elevated PPG often precedes fibrosis in NAFLD, suggesting a bidirectional relationship between these pathological processes. Second, HVPG underestimates PPG in NAFLD, suggesting that portal hypertension is more prevalent in this condition than currently believed. Third, cellular mechanoresponses generated early in the pathogenesis of NAFLD provide a mechanistic explanation for the pressure-fibrosis paradigm. Finally, a better understanding of liver mechanobiology in NAFLD may aid in the development of novel pharmaceutical targets for prevention and management of this disease.

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Section: Portal Hypertension Begins In Precirrhotic Nafld and May Pre...mentioning

confidence: 99%

Section: Portal Hypertension Begins In Precirrhotic Nafld and May Pre...mentioning

confidence: 99%

Portal Hypertension in Nonalcoholic Fatty Liver Disease: Challenges and Paradigms

Mitten¹,

Portincasa²,

Baffy³

2023

J Clin Transl Hepatol

View full text Add to dashboard Cite

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Therapies for Alcohol-Related Liver Disease and for Non-Alcoholic Fatty Liver Disease

Yoshiji

Namisaki

Kaji

et al. 2022

Portal Hypertension VII

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Distinct features of the portalhypertensive syndrome in patients with advanced chronic liver disease due to non-alcoholic steatohepatitis

Cited by 2 publications

References 0 publications

Portal Hypertension in Nonalcoholic Fatty Liver Disease: Challenges and Paradigms

Portal Hypertension in Nonalcoholic Fatty Liver Disease: Challenges and Paradigms

Therapies for Alcohol-Related Liver Disease and for Non-Alcoholic Fatty Liver Disease

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