Distinct Functional and Structural Cerebral Abnormalities in Eating Disorders in the Light of Diagnostic Classification Systems

Joos, Andreas; Saum, Barbara; Hartmann, Armin; Tüscher, Oliver; Elst, Ludger Tebartz van; Zeeck, Almut

doi:10.1159/000337747

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Our findings help to bridge basic neuroscience to clinical relevance Joos et al, 2012). As stated above, weight loss after treatment is one of the main risk factors for relapse and chronicity (Kaplan et al, 2009).…”

Section: Brain Volumes and Bmi At 1-year Follow-upsupporting

confidence: 57%

Brain volume reduction predicts weight development in adolescent patients with anorexia nervosa

Seitz

Walter

Mainz

et al. 2015

Journal of Psychiatric Research

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Section: Brain Volumes and Bmi At 1-year Follow-upsupporting

confidence: 57%

Brain volume reduction predicts weight development in adolescent patients with anorexia nervosa

Seitz

Walter

Mainz

et al. 2015

Journal of Psychiatric Research

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“…52,53 A problem, though, might be the typically different methods used across studies of eating disorders specifically 54 and psych iatry research in general, and it is probably still too early to develop more comprehensive models. 55 However, building on the aforementioned publications, 52,53 our results in recent years using similar methods suggest larger orbitofrontal cortex volume in individuals with anorexia nervosa across ages and states of illness, as well as greater insula response to the prediction error model task.…”

Section: Discussionmentioning

confidence: 99%

Prediction error and somatosensory insula activation in women recovered from anorexia nervosa

Frank

Collier

Shott

et al. 2016

jpn

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“…To support this hypothesis, methodological improvements that can investigate relations between the function of the OFC and performance of tasks that directly induce SI are needed in future studies. In addition, a comparison of AN and BN using the same method would be of interest because there is evidence that there are functional and structural cerebral differences between BN and AN [79]. …”

Section: Discussionmentioning

confidence: 99%

Social insecurity in relation to orbitofrontal activity in patients with eating disorders: a near-infrared spectroscopy study

et al. 2014

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BackgroundFunctional neuroimaging techniques are widely used to elucidate changes in brain activity, and various questionnaires are used to investigate psychopathological features in patients with eating disorders (ED). It is well known that social skills and interpersonal difficulties are strongly associated with the psychopathology of patients with ED. However, few studies have examined the association between brain activity and social relationships in patients with ED, particularly in patients with extremely low body weight.MethodsIn this study, 22-channel near-infrared spectroscopy was used to quantify regional hemodynamic changes during a letter fluency task (LFT) in 20 female patients with ED with a mean body mass index of 14.0 kg/m2and 31 female controls (CTLs). Symptoms were assessed using the Eating Disorder Inventory-2 and Beck Depression Inventory. We hypothesized that frontal activity in patients with ED would be lower than in CTLs and would show different correlations with psychopathological features compared with CTLs.ResultsThe LFT performance and score on the social insecurity subscale of the Eating Disorder Inventory-2 were significantly higher in the ED group than in the CTL group. The mean change in oxygenated hemoglobin (oxy-Hb) in bilateral frontal regions during the LFT was significantly smaller in the ED group than in the CTL group. Social insecurity score was positively correlated with the concentration of oxy-Hb in the bilateral orbitofrontal cortex in the ED group but not in the CTL group.ConclusionsThese results suggest that activity of the orbitofrontal cortex is associated with social insecurity and disturbed in patients with ED. Therefore, disturbed orbitofrontal cortex activity may underlie the lack of insight and social isolation that is characteristic of patients with ED.

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Distinct Functional and Structural Cerebral Abnormalities in Eating Disorders in the Light of Diagnostic Classification Systems

Cited by 5 publications

References 22 publications

Brain volume reduction predicts weight development in adolescent patients with anorexia nervosa

Brain volume reduction predicts weight development in adolescent patients with anorexia nervosa

Prediction error and somatosensory insula activation in women recovered from anorexia nervosa

Social insecurity in relation to orbitofrontal activity in patients with eating disorders: a near-infrared spectroscopy study

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