Distinct Functional Connectivity Patterns Are Associated With Social and Cognitive Lifestyle Factors: Pathways to Cognitive Reserve

Fleck, Jessica I.; Arnold, Molly; Dykstra, Benjamin; Casario, Katharine; Douglas, Elizabeth; Morris, Otto

doi:10.3389/fnagi.2019.00310

Cited by 26 publications

(39 citation statements)

References 70 publications

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“…In essence, the concept of reserve suggests that some initial conditions of brain physiology and function-often measured using neuroimaging techniques-heavily constrain the observed clinical sequelae." Consistent with an increasing number of studies suggesting that RSN organization is associated with reserve level and reflects the influence of reserve on brain network organization (36), in our study, we found that a higher connectivity at baseline could characterize MS patients with a higher functional reserve. Indeed, previous studies have linked altered FC with reduced or preserved functional reserve in MS (37)(38)(39).…”

Section: Functional Reserve Engagement As a Putative Mechanism For Nesupporting

confidence: 91%

Increased Within-Network Functional Connectivity May Predict NEDA Status in Fingolimod-Treated MS Patients

et al. 2021

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Only a few studies have evaluated the brain functional changes associated with disease-modifying therapies (DMTs) in multiple sclerosis (MS), though none used a composite measure of clinical and MRI outcomes to evaluate DMT-related brain functional connectivity (FC) measures predictive of short-term outcome. Therefore, we investigated the following: (1) baseline FC differences between patients who showed evidence of disease activity after a specific DMT and those who did not; (2) DMT-related effects on FC, and; (3) possible relationships between DMT-related FC changes and changes in performance. We used a previously analyzed dataset of 30 relapsing MS patients who underwent fingolimod treatment for 6 months and applied the “no evidence of disease activity” (NEDA-3) status as a clinical response indicator of treatment efficacy. Resting-state fMRI data were analyzed to obtain within- and between-network FC measures. After therapy, 14 patients achieved NEDA-3 status (hereinafter NEDA), while 16 did not (EDA). The two groups significantly differed at baseline, with the NEDA group having higher within-network FC in the anterior and posterior default mode, auditory, orbitofrontal, and right frontoparietal networks than the EDA. After therapy, NEDA showed significantly reduced within-network FC in the posterior default mode and left frontoparietal networks and increased between-network FC in the posterior default mode/orbitofrontal networks; they also showed PASAT improvement, which was correlated with greater within-network FC decrease in the posterior default mode network and with greater between-network FC increase. No significant longitudinal FC changes were found in the EDA. Taken together, these findings suggest that NEDA status after fingolimod is related to higher within-network FC at baseline and to a consistent functional reorganization after therapy.

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Section: Functional Reserve Engagement As a Putative Mechanism For Nesupporting

confidence: 91%

Increased Within-Network Functional Connectivity May Predict NEDA Status in Fingolimod-Treated MS Patients

et al. 2021

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“…Taking these data into account, it might be also possible that our results could be modulated by an age-related effect. Nevertheless, in a posterior study, Fleck et al (2019) taking age as a continuous covariate (range age 35-75) and using LLC as well, did not found any significant effect of age, but still important differences in LLC between high and low CR groups. High social CR was related to greater local and long-range LLC in theta and low alpha, and high cognitive CR was associated with greater low alpha long-range LLC between the occipital lobe and other cortical regions.…”

Section: Correlational Analysismentioning

confidence: 77%

“…An inverse correlation between the CSD of delta activity in the occipital region and the CRI was also observed in our study, so the higher the CRI the lower the posterior delta activity. In this line, Sánchez-López et al ( 2018) found less delta and theta activity in participants with high levels of physical activity, considered a protective factor for cognitive function sometimes proposed as another proxy of cognitive reserve (Dik et al, 2003;Fleck et al, 2019). In addition, an increase in delta oscillatory activity has been associated with cognitive dysfunction (Babiloni et al, 2006), and therefore low levels of delta might be considered a neuroprotective factor against cognitive decline.…”

Section: Correlational Analysismentioning

confidence: 99%

“…Although the literature analyzing the EEG correlates of CR in healthy aging is not so prolific as with other imaging techniques, several findings suggest that EEG is sensitive to the electrophysiological changes associated with various CR proxies (Fleck et al, 2019). Some studies have tried to associate different EEG parameters, both task-related as for ERPs or at rest through the study of spontaneous oscillations, to different proxies of CR (see Sneidere et al, 2020 andBalart-Sánchez et al, 2020 for reviews).…”

Section: Introductionmentioning

confidence: 99%

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Resting-state electroencephalographic correlates of cognitive reserve: Moderating the age-related worsening in cognitive function

Buján¹,

Sampaio²,

Pinal³

2022

Preprint

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Measurement of cognitive reserve (CR) is a matter of constant reviews and developments due to the difficulty to assess it directly, being socio-behavioral indexes used as indirect proxies. An effort to unravel the neural correlates underlying CR seems mandatory, and strongly supported by the neuroscientific literature. Neurophysiological measures through electroencephalography (EEG) have proven to be a promising, almost inexpensive method to study the CR neural correlates. In line with the recommendations of Stern et al. (2020), the aim of the present study has been to demonstrate that resting-state EEG measures may moderate the relationship between age-related brain changes and cognitive status; thus, constituting an objective neural index of CR.Our results show that two resting-state EEG measures, delta current source density in the occipital region and beta 2 connectivity between limbic and occipital regions in the right hemisphere, moderate the relation between age and cognitive performance, indexing neuroprotective effects on cognition during the aging process. These results not only shed light on the neural mechanisms involved in CR but also allow us to propose features to be taken into account in order to enhance the results of interventions to delay the onset of cognitive deficits.

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“…[64][65][66] In the context of typical aging, social isolation and loneliness increase risk of mortality 67 and age-related health problems, such as cardiovascular disease, chronic respiratory diseases, cancer, diabetes, and dementia. [68][69][70] Social isolation is also linked to accelerated brain aging, demonstrated by declines in global cognition 68,[71][72][73][74] and reductions in functional connectivity 75 and peak alpha frequency. 76 However, the link between social isolation and aging outcomes has not been investigated in ASD.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological signatures of brain aging in autism spectrum disorder

Dickinson

Jeste

Milne

2021

Preprint

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Emerging evidence suggests that aging processes may be altered in adults with autism spectrum disorder (ASD). However, it remains unclear if oscillatory slowing, a key neurophysiological change in the aging brain, manifests atypically in this population. This study sought to examine patterns of age-related oscillatory slowing in adults with ASD, captured by reductions in the brain’s peak alpha frequency. Resting-state EEG data from adults (18-70 years) with ASD (N=93) and age-matched neurotypical (NT) controls (N=87) were pooled from three independent datasets. A robust curve-fitting procedure quantified the peak frequency of alpha oscillations (7-13Hz) across all brain regions. Associations between peak alpha frequency and age were assessed and compared between groups. Consistent with characteristic patterns of oscillatory slowing, peak alpha frequency was negatively associated with age across the entire sample (p<.0001). A significant group by age interaction revealed that this relationship was more pronounced in adults with ASD (p<.01), suggesting that that age-related oscillatory slowing may be accelerated in this population. Scalable EEG measures such as peak alpha frequency could provide insights into neural aging that are crucially needed to inform care plans and preventive interventions that can promote successful aging in ASD.

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Distinct Functional Connectivity Patterns Are Associated With Social and Cognitive Lifestyle Factors: Pathways to Cognitive Reserve

Cited by 26 publications

References 70 publications

Increased Within-Network Functional Connectivity May Predict NEDA Status in Fingolimod-Treated MS Patients

Increased Within-Network Functional Connectivity May Predict NEDA Status in Fingolimod-Treated MS Patients

Resting-state electroencephalographic correlates of cognitive reserve: Moderating the age-related worsening in cognitive function

Electrophysiological signatures of brain aging in autism spectrum disorder

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