Distinct Functions of the Tribolium zerknu¨llt Genes in Serosa Specification and Dorsal Closure

Zee, Maurijn van der; Berns, Nicola; Roth, Siegfried

doi:10.1016/j.cub.2005.02.057

Cited by 151 publications

(189 citation statements)

References 44 publications

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“…4) as found in other insects, and in the CNS in late honey bee embryos. CNS expression is not reported for zen genes in Tribolium (Falciani et al 1996;van der Zee et al 2005), Diptera (Doyle et al 1989), or Schistocerca (Dearden et al 2000), implying a novel function in the honey bee. The second rogue Hox gene, fushi tarazu (ftz), acts in Drosophila in segmentation and nervous system patterning.…”

Section: The Hox Complexmentioning

confidence: 89%

Patterns of conservation and change in honey bee developmental genes

Dearden

Wilson²,

Sablan³

et al. 2006

Genome Res.

149

155

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The current insect genome sequencing projects provide an opportunity to extend studies of the evolution of developmental genes and pathways in insects. In this paper we examine the conservation and divergence of genes and developmental processes between Drosophila and the honey bee; two holometabolous insects whose lineages separated ∼300 million years ago, by comparing the presence or absence of 308 Drosophila developmental genes in the honey bee. Through examination of the presence or absence of genes involved in conserved pathways (cell signaling, axis formation, segmentation and homeobox transcription factors), we find that the vast majority of genes are conserved. Some genes involved in these processes are, however, missing in the honey bee. We have also examined the orthology of Drosophila genes involved in processes that differ between the honey bee and Drosophila. Many of these genes are preserved in the honey bee despite the process in which they act in Drosophila being different or absent in the honey bee. Many of the missing genes in both situations appear to have arisen recently in the Drosophila lineage, have single known functions in Drosophila, and act early in developmental pathways, while those that are preserved have pleiotropic functions. An evolutionary interpretation of these data is that either genes with multiple functions in a common ancestor are more likely to be preserved in both insect lineages, or genes that are preserved throughout evolution are more likely to co-opt additional functions.

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Section: The Hox Complexmentioning

confidence: 89%

Patterns of conservation and change in honey bee developmental genes

Dearden

Wilson²,

Sablan³

et al. 2006

Genome Res.

149

155

View full text Add to dashboard Cite

show abstract

“…Indeed, immune gene expression was shown to be restricted to the extraembryonic regions of the egg in Manduca sexta (Gorman et al, 2004). By using RNAi to prevent the development of the serosa (van der Zee et al, 2005), we were able to show that the endogenous innate immune response of the Tribolium castaneum egg is completely dependent on the extraembryonic serosa (Jacobs et al, 2014a;. Immune gene activity in insect eggs is not only activated by a pathogen attack, but it can also be enhanced by parental immune priming.…”

Section: Introductionmentioning

confidence: 93%

Endogenous egg immune defenses in the yellow mealworm beetle (Tenebrio molitor)

Jacobs

Gallagher

Evison

et al. 2017

Developmental & Comparative Immunology

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In order to survive microbe encounters, insects rely on both physical barriers as well as local and systemic immune responses. Most research focusses on adult or larval defenses however, whereas insect eggs are also in need of protection. Lately, the defense of eggs against microbes has received an increasing amount of attention, be it through endogenous egg defenses, trans-generational immune priming (TGIP) or parental investment. Here we studied the endogenous immune response in eggs and adults of Tenebrio molitor. We show that many immune genes are induced in both adults and eggs. Furthermore, we show that eggs reach comparable levels of immune gene expression as adults. These findings show that the eggs of Tenebrio are capable of an impressive endogenous immune response, and indicate that such inducible egg defenses are likely common in insects.

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“…In Drosophila, zen is dorsally expressed during blastoderm development and is required for development of the amnioserosa (Wakimoto et al, 1984;Doyle et al, 1986). zen is also expressed in the anterior and dorsal regions that give rise to extraembryonic membranes in other insects (Falciani et al, 1996;Stauber et al, 2002); in Tribolium, anterior expression of zen1 has also been shown to specify serosa cell fates, differentiating them from those of the more posterior germ rudiment (van der Zee et al, 2005). Nasonia Hunchback is also strongly expressed in the nervous system, approximately during the period of head involution, in a pattern that appears to be similar to that observed in the nervous system of other insects (Woff et al, 1995;Rohr et al, 1999;Patel et al, 2001).…”

Section: Comparative Timing and Expression Of Nasonia And Drosophila mentioning

confidence: 99%

A major role for zygotichunchbackin patterning theNasoniaembryo

et al. 2005

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Developmental genetic analysis has shown that embryos of the parasitoid wasp Nasonia vitripennis depend more on zygotic gene products to direct axial patterning than do Drosophila embryos. In Drosophila, anterior axial patterning is largely established by bicoid, a rapidly evolving maternal-effect gene, working with hunchback, which is expressed both maternally and zygotically. Here,we focus on a comparative analysis of Nasonia hunchback function and expression. We find that a lesion in Nasonia hunchback is responsible for the severe zygotic headless mutant phenotype, in which most head structures and the thorax are deleted, as are the three most posterior abdominal segments. This defines a major role for zygotic Nasonia hunchback in anterior patterning, more extensive than the functions described for hunchback in Drosophila or Tribolium. Despite the major zygotic role of Nasonia hunchback, we find that it is strongly expressed maternally, as well as zygotically. NasoniaHunchback embryonic expression appears to be generally conserved; however, the mRNA expression differs from that of Drosophila hunchback in the early blastoderm. We also find that the maternal hunchback message decays at an earlier developmental stage in Nasonia than in Drosophila, which could reduce the relative influence of maternal products in Nasonia embryos. Finally, we extend the comparisons of Nasonia and Drosophila hunchback mutant phenotypes, and propose that the more severe Nasonia hunchback mutant phenotype may be a consequence of differences in functionally overlapping regulatory circuitry.

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Distinct Functions of the Tribolium zerknu¨llt Genes in Serosa Specification and Dorsal Closure

Cited by 151 publications

References 44 publications

Patterns of conservation and change in honey bee developmental genes

Patterns of conservation and change in honey bee developmental genes

Endogenous egg immune defenses in the yellow mealworm beetle (Tenebrio molitor)

A major role for zygotichunchbackin patterning theNasoniaembryo

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