Distinct genetic alterations in Burkitt-like lymphoma with 11q aberration and Burkitt lymphoma: a novel case report of composite lymphoma

Kim, Mee-Jeong; Hwang, Hyeon-Shik; Yoon, Dok Hyun; Chun, Sung-Min; Go, Heounjeong

doi:10.3324/haematol.2021.280543

Cited by 2 publications

(3 citation statements)

References 14 publications

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“… 9 There are also case reports of BL and HGBL-11q composite lymphoma. 22 One case of BL-11q was present in this study. It is unclear whether BL-11q is clinically or molecular pathologically different from pure BL, but for the time being, it should be diagnosed and treated as BL.…”

Section: Discussionmentioning

confidence: 49%

“…Most case reports of HGBL-11q have been conducted in children and young adults, 8 , 21 , 28 - 33 but some cases in middle and old age have been reported. 7 , 22 , 34 - 37 In this study, two HGBL-11q cases were pediatric patients, while five HGBL-11q and two DLBCL-11q cases were middle-aged and elderly patients. Although HGBL-11q tends to be more frequent among younger patients, it is important to recognize that the tumor can occur in middle-aged and older patients.…”

Section: Discussionmentioning

confidence: 74%

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High-grade B-cell lymphoma with 11q aberrations: A single-center study

Yamada

Oka

Muramatsu

et al. 2023

J Clin Exp Hematopathol

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High-grade B-cell lymphoma with 11q aberrations (HGBL-11q) is a new mature high-grade B-cell lymphoma (HGBL) to be described in the World Health Organization Classification 5 th edition (WHO-5). 1 HGBL-11q is a relatively rare B-cell lymphoma that exhibits a Burkitt-like or an intermediate to blastoid appearance but has 11q aberrations without MYC translocation. The concept of HGBL originated from B-cell lymphoma (BCL), unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) (BCL-U), which was proposed as a provisional entity in the WHO 4 th edition (WHO-4). 2 This category was thought to apply to aggressive lymphomas with inferior prognosis, such as BL without MYC translocation, atypical BL with marked nuclear atypia, BL with BCL2 expression, and double-hit lymphoma, which had been discussed previously. In the revised 4th edition of WHO (WHO-4R), BCL-U was reclassified as HGBL with MYC and BCL2 and/or BCL6 rearrangements, and HGBL, not otherwise specified (NOS). 3 HGBL, NOS included cases that could not be morphologically, immunohistochemically, or genetically classified as BL, Burkitt-like lymphoma with 11q aberration (BLL-11q), or other aggressive BCLs. HGBL without MYC translocation with BLL-11q was tentatively designated as a separate disease as BLL-11q in WHO-4R; BLL-11q will be changed to HGBL-11q in WHO-5.BL is an aggressive lymphoma of well-known origin in the germinal center dark zone, characterized by marked cell proliferation due to MYC translocation. The dense, cohesive growth pattern of medium-sized tumor cells and the "starry sky" appearance produced by scattered macrophages are characteristic of BL. BLL-11q was established because 11q aberrations were found in MYC-negative BL and post-transplant-associated BL. [4][5][6] Several studies of HIV-associated MYC-negative BL with 11q aberrations have been reported. 7,8 Recent studies have reported that 11q aberrations were not limited to the Burkitt-like morphology cases, but were also found in BL, HGBL, and DLBCL. 7,9,10 Regarding genetic variation, HGBL-11q was more similar to germinal center B-cell (GCB) type DLBCL than to BL, 10 and it has

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 74%

High-grade B-cell lymphoma with 11q aberrations: A single-center study

Yamada

Oka

Muramatsu

et al. 2023

J Clin Exp Hematopathol

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“…They think that the term aggressive B-cell lymphoma with 11q aberration captures their pathological features[ 16 ]. Recently, Kim et al [ 17 ] reported a composite lymphoma of BLL-11q and BL. They suggest BLL-11q as a distinct entity from BL.…”

Section: Discussionmentioning

confidence: 99%

Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report

Yang¹,

Wang²

2022

WJCC

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BACKGROUND Burkitt-like lymphoma with 11q aberration (BLL-11q) is a rare provisional lymphoma, and the majority of cases are usually diagnosed by excisional lymph node biopsy. Here we report a case of BLL-11q diagnosed by needle biopsy of the liver in order to improve further understanding of the disease, reduce misdiagnosis, and identify treatment regimens. CASE SUMMARY The patient was a 67-year-old male. He complained of increased frequency of stools for more than one year, periumbilical pain and discomfort exceeding 3 mo. A computed tomography scan suggested an appendiceal malignant tumor with multiple metastases of the peritoneum, omentum, and liver. Needle biopsy of liver nodules showed that the tumor cells were of median size, the shape was consistent, a small number of tumor cells were large, the “starry sky” pattern was evident, and some tissue cells showed multiple apoptotic debris with coarse particles. Immunohistochemistry was positive for CD20, CD10, BCL6, and MYC. The Ki-67 proliferation index was more than 95%. Molecular biological detection indicated a lack of MYC , BCL2 and BCL6 gene rearrangement with 11q aberration. Therefore, the diagnosis was BLL-11q of the liver. After eight courses of chemotherapy, the abdominal and pelvic peritoneal masses and liver nodules had almost disappeared. The patient recovered well after a follow-up period of more than 13 mo. CONCLUSION BLL-11q is rare, but patients treated with standard chemotherapy for Burkitt lymphoma can have a good prognosis. Reducing the dose of chemotherapy or developing specific therapies to prevent overtreatment may be considered, but more case studies are needed.

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Distinct genetic alterations in Burkitt-like lymphoma with 11q aberration and Burkitt lymphoma: a novel case report of composite lymphoma

Abstract: Not available.

Cited by 2 publications

References 14 publications

High-grade B-cell lymphoma with 11q aberrations: A single-center study

High-grade B-cell lymphoma with 11q aberrations: A single-center study

Burkitt-like lymphoma with 11q aberration confirmed by needle biopsy of the liver: A case report

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