Distinct Genotype of Hantavirus Infection in Rodents in Jiangxi Province, China, in 2020–2021

Abstract

Background: Hantavirus causes hemorrhagic fever with renal syndrome, thus posing a major threat to human health in Jiangxi Province, China. Both Hantaan virus (HTNV) and Seoul virus (SEOV) have been found to be endemic in the province. Methods: Rodents were trapped from Gaoan Anyi and Tonggu counties in Jiangxi Province in 2020–2021. Hantavirus specific antibodies in the blood and RNA in the lung samples from the captured mammals were detected and analyzed. Results: A total of 889 small mammals from seven species were collected. Positive detection was observed for hantavirus antibodies in 9.8% (87/889), SEOV RNA in 1% (9/889) and HTNV RNA in 2.6% (23/889). The difference in detection rates between regions was significant. Phylogenetic analysis of the obtained partial sequences of M and S segments revealed that two distinct genotypes of HTNV and three genotypes of SEOV were co-circulating in the captured mammals, with a regionally specific distribution. Conclusion: Multiple distinct genotypes of hantavirus are co-circulating in the province. Further studies in broader areas remain needed to reveal the diversity of hantaviruses.

Single dose recombinant VSV based vaccine elicits robust and durable neutralizing antibody against Hantaan virus

“…Check for updates Hui Zhang 1,5 , He Liu 1,5 , Jing Wei 1,2,5 , Yamei Dang 1,5 , Yuan Wang 1 , Qiqi Yang 1 , Liang Zhang 1 , Chuantao Ye 1 , Bin Wang 3 , Xiaolei Jin 4 , Linfeng Cheng 1 , Hongwei Ma 1 , Yangchao Dong 1 , Yinghui Li 1 , Yinlan Bai 1 , Xin Lv 1 , Yingfeng Lei 1 , Zhikai Xu 1 , Wei Ye 1 & Fanglin Zhang 1 Hantaan virus (HTNV) is a pathogenic orthohantavirus prevalent in East Asia that is known to cause hemorrhagic fever with severe renal syndrome (HFRS), which has a high fatality rate. However, a Food and Drug Administration (FDA)-approved vaccine is not currently available against this virus.…”

“…Belongs to the order Bunyavirales , family Hantaviridae , and genus Orthohantavirus , HTNV is an enveloped, trisegmented, negative-sense ribonucleic acid (RNA) virus. The small (S) segment encodes the nucleocapsid protein, the medium (M) segment encodes the glycoprotein precursor (GPC), and the large (L) segment encodes the RNA-dependent RNA polymerase (RdRp) 5 . GPC is cleaved by host proteases at the conserved WAASA pentapeptide site into two mature envelope glycoproteins, glycoprotein N (Gn) and glycoprotein C (Gc) 6 .…”

Environmental Analysis of Hemorrhagic Fever in Iraq Using Machine Learning

“…Rodents serve as significant reservoirs for numerous zoonotic pathogens [25][26][27] [28][29] The number of burrows determines the frequency (Runways count) per dunam and the number of affected dunams in each governorate. In Dhi Qar Governorate, this totaled 21,860 dunams.…”

Spatial-temporal patterns and influencing factors for hemorrhagic fever with renal syndrome: A 16-year national surveillance analysis in China

“…Hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease caused by varying serotypes of Hantavirus (HV), such as Hantaan virus (HTNV), Seoul virus (SEOV), Puumala virus (PUUV), and Dobrava virus (DOBV) [ 1 ]. Humans were infected with HFRS primarily through contact with excrement and secretions from infected animals [ 2 ]. The global annual incidence of HFRS is estimated to be approximately 60,000–150,000 cases [ 3 ], spreading across numerous countries globally.…”