Distinct geographic clustering of oncogenic human papillomaviruses multiple infections in cervical cancers: Results from a worldwide cross‐sectional study

Pimenoff, Ville N.; Tous, Sara; Benavente, Yolanda; Alemany, Laia; Quint, Wim; Bosch, F. Xavier; Bravo, Ignacio G.; Sanjosé, Sílvia de

doi:10.1002/ijc.31964

Cited by 18 publications

(38 citation statements)

References 48 publications

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“…The prevalence of HPV multiple infections in ADC significantly differed by geographic regions of China in our study. This finding was generally concordant with Pimenoff et al's recent observations of global cervical cancer. Although the majority of invasive cancer in their study were squamous cell cancer, three‐fold higher prevalence of HPV coinfections from Africa compared to the rest of the world were found .…”

Section: Discussionsupporting

confidence: 91%

“…This finding was generally concordant with Pimenoff et al's recent observations of global cervical cancer. Although the majority of invasive cancer in their study were squamous cell cancer, three‐fold higher prevalence of HPV coinfections from Africa compared to the rest of the world were found . Considering the association of sexual behavior with increased risk of acquiring multiple infections of HPV and the role of host immune system in the clearance of HPV infections, the geographic differences of the prevalence of multiple infections of HPV in China may be related to varied context of sex behaviors in different geographic regions, and different host immune‐genetic backgrounds in specific regions, which always reflects socioeconomic settings, hygiene habits and genetic susceptibility .…”

Section: Discussionsupporting

confidence: 91%

“…Coinfection with multiple types of HPV was more commonly observed in women with precancerous lesions (between 15% and 41%) than in normal cytology (between 1% and 3%) and invasive cervical cancer (between 6% and 8%) . Regarding the ADC, the prevalence of 8.4% for HPV coinfections was found in our study, consistent with that of 7.0% in a worldwide meta‐analysis of 760 ADC cases, and 8.5% in a study of 1408 ADC cases worldwide .…”

Section: Discussionsupporting

confidence: 90%

“…Considering the association of sexual behavior with increased risk of acquiring multiple infections of HPV and the role of host immune system in the clearance of HPV infections, the geographic differences of the prevalence of multiple infections of HPV in China may be related to varied context of sex behaviors in different geographic regions, and different host immune‐genetic backgrounds in specific regions, which always reflects socioeconomic settings, hygiene habits and genetic susceptibility . Africa's high prevalence of HIV‐infected population with compromised immunity might support this assumption . China's rapid but geographically asynchronous industrialization and urbanization during the last three decades have coincided with an epidemic of sexually transmitted disease, which may partly interpret the geographic differences of HPV coinfections in ADC cases in our study.…”

Section: Discussionmentioning

confidence: 99%

“…A large number of studies show that women infected with multiple types of HPV are more likely to have abnormal cytology, and suffer from a subsequent increased risk of cervical cancer or precancers . More recently, the coinfection pattern of HPV types in the invasive cervical cancer has been found associated with geographic characteristics . However, it remains unclear which determinants are related with the clustering patterns of HPV coinfections in ADC cases.…”

Section: Introductionmentioning

confidence: 99%

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Clustering patterns of type‐type combination in multiple genotypes infections of human papillomavirus in cervical adenocarcinoma

et al. 2019

Journal of Medical Virology

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Coinfections with multiple types of human papillomavirus (HPV) occur in cervical adenocarcinoma (ADC). However, it remains unclear the clustering patterns of multiple types in HPV coinfections and relevant factors in ADC. A total of 718 paraffin-embedded ADC specimens were collected in China and tested for HPV genotypes using SPF10-INNO-LIPA. The prevalence of HPV coinfections and clustering patterns by geographical regions, histological subtypes and ages were assessed. Type-specific attribution of HPV to ADC adjusted by HPV coinfections were calculated. The prevalence of HPV coinfections was found to be 8.4% in ADC cases with slight variation by geographic regions between 2.2% and 12.5%. The 88.3% of all HPV multiple infections in ADC were two types of HPV coinfections with predominant combination of HPV 16 and HPV 18. The attribution to ADC was 88.0% for HPV 16/18 targeted by bivalent and quadrivalent vaccine and 96.8% for HPV 16/ 18/31/33/45/52/58 targeted by nonavalent vaccine. Clustering patterns of multiple types were related with histological categories and age at diagnosis. In conclusion, HPV coinfections are uncommonly prevalent in ADC cases with slight variation by geographic regions and distinct clustering patterns of multiple types by histological subtypes and ages at diagnosis. The high attribution of carcinogenic HPV types to ADC predicts potential protection of HPV vaccine against ADC. K E Y W O R D S cervical adenocarcinoma, clustering patterns, human papillomavirus, multiple genotypes 1 | INTRODUCTION Cervical adenocarcinoma (ADC), a histological subtype of cervical cancer, composes approximately 10% to 20% of all cervical cancer cases. 1,2 In contrast with the declined incidence of squamous cell cancer in an era of ever-increasing coverage of cervical cancer screening and human papillomavirus (HPV) vaccine, ADC has become more common in the past decades, even in countries with organized screening. 3-6 The estimated global incidence of ADC was 1.6 cases per 100 000 women, and approximately 56 805 new cases developed worldwide in 2015. 2 Persistent infection with high-risk types of HPV has been established as an essential cause of cervical cancer. 7,8 Over 200 types of HPV out of more than 350 different papillomaviruses Li Dong and Tingyuan Li contributed equally to this work.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clustering patterns of type‐type combination in multiple genotypes infections of human papillomavirus in cervical adenocarcinoma

et al. 2019

Journal of Medical Virology

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Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral‐host interaction with implications for disease intervention

Pinheiro

Gage

Clifford

et al. 2020

Intl Journal of Cancer

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HPV35 has been found in only 2% of invasive cervical cancers (ICC) worldwide but up to 10% in Sub-Saharan Africa, warranting further investigation and consideration of impact on preventive strategies. We studied HPV35 and ethnicity, in relation to the known steps in cervical carcinogenesis, using multiple large epidemiologic studies in the U.S. and internationally. Combining five U.S. studies, we measured HPV35 positivity and, in Northern California, observed HPV35 type-specific population

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Assessing the risk of cervical neoplasia in the post‐HPV vaccination era

Lehtinen

Pimenoff

Nedjai

et al. 2022

Intl Journal of Cancer

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This review is based on the recent EUROGIN scientific session: “Assessing risk of cervical cancer in the post‐vaccination era,” which addressed the demands of cervical intraepithelial neoplasia (CIN)/squamous intraepithelial lesion (SIL) triage now that the prevalence of vaccine‐targeted oncogenic high‐risk (hr) human papillomaviruses (HPVs) is decreasing. Change in the prevalence distribution of oncogenic HPV types that follows national HPV vaccination programs is setting the stage for loss of positive predictive value of conventional but possibly also new triage modalities. Understanding the contribution of the latter, most notably hypermethylation of cellular and viral genes in a new setting where most oncogenic HPV types are no longer present, requires studies on their performance in vaccinated women with CIN/SIL that are associated with nonvaccine HPV types. Lessons learned from this research may highlight the potential of cervical cells for risk prediction of all women's cancers.

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Distinct geographic clustering of oncogenic human papillomaviruses multiple infections in cervical cancers: Results from a worldwide cross‐sectional study

Cited by 18 publications

References 48 publications

Clustering patterns of type‐type combination in multiple genotypes infections of human papillomavirus in cervical adenocarcinoma

Clustering patterns of type‐type combination in multiple genotypes infections of human papillomavirus in cervical adenocarcinoma

Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral‐host interaction with implications for disease intervention

Assessing the risk of cervical neoplasia in the post‐HPV vaccination era

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