Distinct Immunological Features of Inflammatory Demyelinating Diseases of the Central Nervous System

Chen, Bin; Gui, Mengcui; Ji, Suqiong; Xie, Yi; Tian, Dai-Shi; Bu, Bitao

doi:10.1159/000519835

Cited by 9 publications

(8 citation statements)

References 47 publications

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“…Therefore, whether the increase in monocytes and lymphocytes means the treatment is effective needs further research. Finally, more attention should be paid to the pathological changes of NMOSD as the decline of NK cells was also shown to be absent in MS ( Chen et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Predictive role of blood-based indicators in neuromyelitis optica spectrum disorders

et al. 2023

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IntroductionThis study aimed to assess the predictive role of blood markers in neuromyelitis optica spectrum disorders (NMOSD).MethodsData from patients with NMOSD, multiple sclerosis (MS), and healthy individuals were retrospectively collected in a 1:1:1 ratio. The expanded disability status scale (EDSS) score was used to assess the severity of the NMOSD upon admission. Receiver operating characteristic (ROC) curve analysis was used to distinguish NMOSD patients from healthy individuals, and active NMOSD from remitting NMOSD patients. Binary logistic regression analysis was used to evaluate risk factors that could be used to predict disease recurrence. Finally, Wilcoxon signed-rank test or matched-sample t-test was used to analyze the differences between the indicators in the remission and active phases in the same NMOSD patient.ResultsAmong the 54 NMOSD patients, neutrophil count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) (platelet × NLR) were significantly higher than those of MS patients and healthy individuals and positively correlated with the EDSS score of NMOSD patients at admission. PLR can be used to simultaneously distinguish between NMOSD patients in the active and remission phase. Eleven (20.4%) of the 54 patients had recurrence within 12 months. We found that monocyte-to-lymphocyte ratio (MLR) (AUC = 0.76, cut-off value = 0.34) could effectively predict NMOSD recurrence. Binary logistic regression analysis showed that a higher MLR at first admission was the only risk factor for recurrence (p = 0.027; OR = 1.173; 95% CI = 1.018–1.351). In patients in the relapsing phase, no significant changes in monocyte and lymphocyte count was observed from the first admission, whereas patients in remission had significantly higher levels than when they were first admitted.ConclusionHigh PLR is a characteristic marker of active NMOSD, while high MLR is a risk factor for disease recurrence. These inexpensive indicators should be widely used in the diagnosis, prognosis, and judgment of treatment efficacy in NMOSD.

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Section: Discussionmentioning

confidence: 99%

Predictive role of blood-based indicators in neuromyelitis optica spectrum disorders

et al. 2023

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“…We removed duplicates and screened 308 studies. Finally, we included 6 articles [20][21][22][23][24][25]…”

Section: Study Selectionmentioning

confidence: 99%

Clinical and imagenologic significance of the neutrophil-to-lymphocyte ratio in neuromyelitis optica spectrum disorder: A systematic review with meta-analysis

Cabanillas-Lazo¹,

Cruzalegui-Bazán

Pascual-Guevara

et al. 2023

PLoS ONE

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Background Recently, the neutrophil-lymphocyte ratio (NLR) has become a biomarker for assessing inflammatory stress and prognosis in different diseases. Objective We aimed to conduct a systematic review and meta-analysis to summarize the current evidence on the capacity of the NLR to serve as a biomarker in neuromyelitis optica spectrum disorder (NMOSD). Methods Through a comprehensive systematic search up to December 2021 and using the search terms "neutrophil-to-lymphocyte ratio" and "neuromyelitis optica spectrum disorder" we selected studies evaluating NLR values in NMOSD patients. A meta-analysis was planned, and a narrative synthesis was performed when this was not possible. Subgroup and sensitivity analyses were planned. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach was used to assess certainty of the evidence. Results Six studies were included (1036 patients). A significant increase in the NLR was observed between NMOSD patients and healthy controls with high heterogeneity (MD: 1.04; 95% CI: 0.76; 1.32; I2 = 59%). Regarding NMOSD prognosis, relapse (OR: 1.33 –OR: 2.14) was evaluated as being related to NLR with low certainty. An association with Expanded Disability Status Scale (EDSS) score ≥4 (OR: 1.23 –OR: 1.43) was reported with moderate certainty. An association with the occurrence of lesions on MRI was reported with an OR of 1.52. Conclusion We found the NLR to be useful as a biomarker of NMOSD as it was significantly increased in the patient group compared to the healthy control group with high certainty. Additionally, the NLR was applicable as an indicator of poor prognosis with low to moderate certainty.

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“…Table 2 shows the general characteristics of included studies. Ten studies reported the association between NLR and NMOSD [16,[19][20][21][22][23][24][25][26][27]. All of them were written in English and were designed retrospective.…”

Section: Overviewmentioning

confidence: 99%

“…All of them were written in English and were designed retrospective. Seven studies were conducted in China [16,[20][21][22][25][26][27] , one in the United Kingdom [19], one in Germany and Austria [23], and one in Latin America [24].…”

Section: Overviewmentioning

confidence: 99%

The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder

et al. 2023

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Background: Neuromyelitis Optica (NMO) is a serious condition associated with inflammation. Early diagnosis and detection are critical for early intervention. In this systematic review, we investigate the role of the neutrophil to lymphocyte ratio (NLR) as an important biomarker for NMO. Methods: Ten studies were selected that were sufficiently high quality and then checked for quality. The studies were organized by English language and selective inclusion criteria. Results: NLR was significantly increased in NMO patients compared to controls. The ratio was specifically proportional to severity of disease. More severe disease had a higher ratio. Conclusion: NLR offers a reliable and affordable method for early detection of disease severity. This can help guide appropriate treatment selection and monitor treatment response.

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Distinct Immunological Features of Inflammatory Demyelinating Diseases of the Central Nervous System

Cited by 9 publications

References 47 publications

Predictive role of blood-based indicators in neuromyelitis optica spectrum disorders

Predictive role of blood-based indicators in neuromyelitis optica spectrum disorders

Clinical and imagenologic significance of the neutrophil-to-lymphocyte ratio in neuromyelitis optica spectrum disorder: A systematic review with meta-analysis

The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder

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