Distinct impact of malignancy and allergy on the clinical and immunological features of IgG4-related disease

Takanashi, Satoshi; Akiyama, Mitsuhiro; Furuhashi, Kazunori; Yoshimoto, Keiko; Tanemura, Shuhei; Seki, Nobuhiko; Tsujimoto, Hideto; Chiba, Kenji; Kaneko, Yuko

doi:10.55563/clinexprheumatol/7g2na0

Cited by 5 publications

(4 citation statements)

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“…Indeed, we have observed oligoclonal production of allergen-specific IgE at the lesion sites of IgG4-RD, suggesting a relationship between chronic allergen exposure and disease onset 105. Considering the immunoregulatory role of human IgG4, we assume that Tfh cells may induce local IgG4+B cell differentiation to inhibit IgE-mediated inflammation in a subgroup of patients with IgG4-RD associated with allergies 106. In any case, a detailed understanding of the molecular mechanisms that determine the relative ‘predominance’ of Tfh and Tph cells in specific diseases is highly desired for future research since these mechanisms play a significant role in shaping the immune response and disease progression.…”

Section: The Balance Of Tfh and Tph Cells In Rheumatic And Musculoske...mentioning

confidence: 80%

T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases

et al. 2023

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Recent technological progress has greatly advanced our understanding of human immunology. In particular, the discovery of human T follicular helper (Tfh) and T peripheral helper (Tph) cells has significantly advanced our understanding of human adaptive immune system. Tfh and Tph cells share similar molecular characteristics and both play critical roles in B cell differentiation and maturation. However, they differ in their functional properties, such as chemokine receptor expression and cytokine production. As a result, Tfh cells are mainly involved in B cell differentiation and maturation in germinal centres of secondary lymphoid tissues, while Tph cells are involved in B cell differentiation and tissue damage in peripheral inflammatory lesions. Importantly, the involvement of Tfh and Tph cells in the pathogenesis of rheumatic and musculoskeletal diseases has become clear. In rheumatoid arthritis and systemic lupus erythematosus, Tph cell infiltration is predominant in peripheral inflammatory lesions, whereas Tfh cell infiltration is predominant in the affected lesions of IgG4-related disease. Therefore, the contribution of Tfh and Tph cells to the development of rheumatic and musculoskeletal diseases varies depending on each disease. In this review, we provide an overview of human Tfh and Tph cells and summarise the latest findings on these novel T cell subsets in various rheumatic and musculoskeletal diseases.

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Section: The Balance Of Tfh and Tph Cells In Rheumatic And Musculoske...mentioning

confidence: 80%

T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases

et al. 2023

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“…Therefore, disease-triggering antigens may contribute to the expansion of those T cells. Identification of disease-triggering antigens in each clinical phenotype of pSS or IgG4-RD would facilitate more precise understanding of the pathogenesis in future (33,39). Alternatively, peripheral cytotoxic CD4 and CD8 T cells are reported to be increased in aging, particularly in supercentenarians (40).…”

Section: Discussionmentioning

confidence: 99%

Significant association of CX3CR1+CD8 T cells with aging and distinct clinical features in Sjögren's syndrome and IgG4-related disease

Akiyama,

Yoshimoto,

Kaneko

2023

Clinical and Experimental Rheumatology

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ObjectiveRecent studies have implicated cytotoxic CD4 and CD8 T cells in primary Sjögren's syndrome (pSS) and IgG4-related disease (IgG4-RD), but their association with immune aging and organ-specific clinical features remain unclear.CX3CR1 is expressed on cytotoxic CD4 and CD8 T cells. The aim of this study was to determine associations of peripheral CX3CR1+CD4 and CX3CR1+CD8 T cells with aging and clinical features. Methods Whole blood samples were freshly obtained from consecutive patients with active, treatment-naïve pSS (n=57),IgG4-RD (n=54), and healthy individuals (n=40) and analysed by flow cytometry for CX3CR1+CD4 and CX3CR1+CD8 proportions. Associations of those T cells with aging and clinical features were determined. Results CX3CR1+CD4 and CX3CR1+CD8 T cells selectively expressed perforin and granzyme B. Proportions of CX3CR1+CD4 and CX3CR1+CD8 T cells were significantly higher in pSS and IgG4-RD than in healthy individuals.Higher proportions of CX3CR1+CD8 T cells were associated with aging in pSS and IgG4-RD but not in healthy individuals. Sex differences were not associated with proportions of CX3CR1+CD8 T cells. Furthermore, patients with pSS with interstitial lung disease showed higher proportions of CX3CR1+CD8 T cells than those without interstitial lung disease. IgG4-RD patients with retroperitoneal fibrosis and/or aortitis exhibited higher proportions of CX3CR1+CD8 T cells compared with those with Mikulicz's disease. Moreover, proportions of CX3CR1+CD8 T cells were decreased following glucocorticoid treatment in paralleled with clinical improvements in IgG4-RD. Conclusion CX3CR1+CD8 T cells might be involved in immune aging and distinct clinical phenotypes of patients withpSS or IgG4-RD.

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“…Furthermore, IgG4 may be produced in the process of immune tolerance not only in allergy but also in malignancy as the pathogenesis of IgG4-RD. 6 We also experienced cases in which IgG4-RD improved after resection of malignant tumor without any immunosuppressive treatment. 6 Our case had no occurrences of malignancy or related treatments during the course of his condition, which enabled us to exclude the possibility of malignancy acting as a confounding factor.…”

Section: F I G U R Ementioning

confidence: 99%

“…6 We also experienced cases in which IgG4-RD improved after resection of malignant tumor without any immunosuppressive treatment. 6 Our case had no occurrences of malignancy or related treatments during the course of his condition, which enabled us to exclude the possibility of malignancy acting as a confounding factor. Collectively, these facts indicate that avoidance of chronic antigen exposure by allergy or malignancy can be a primary solution for IgG4-RD.…”

Section: F I G U R Ementioning

confidence: 99%

Avoidance of allergen exposure may ameliorate IgG4‐related disease: A case that improved spontaneously after moving house

Takanashi,

Akiyama,

Kondo

et al. 2023

Int J of Rheum Dis

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Avoidance of allergen exposure may ameliorate IgG4-related disease: A case that improved spontaneously after moving house Dear Editor, immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated inflammatory disease characterized by elevation of serum IgG4 levels and swelling of affected organs. Initial therapeutic response to glucocorticoid is generally good; however, more than half of patients experience relapse during glucocorticoid tapering, indicating that glucocorticoid is not a fundamental treatment.

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Distinct impact of malignancy and allergy on the clinical and immunological features of IgG4-related disease

Cited by 5 publications

References 0 publications

T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases

T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases

Significant association of CX3CR1+CD8 T cells with aging and distinct clinical features in Sjögren's syndrome and IgG4-related disease

Avoidance of allergen exposure may ameliorate IgG4‐related disease: A case that improved spontaneously after moving house

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