2021
DOI: 10.1097/inf.0000000000003086
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Distinct Laboratory and Clinical Features of Secondary Hemophagocytic Lymphohistiocytosis in Pediatric Visceral Leishmaniasis

Abstract: Background: Visceral leishmaniasis (VL) is an endemic in Southern Europe. However, details regarding disease burden, clinical presentations, laboratory markers, management and outcome in children are scarce. Methods: Medical records of children (<14 years) admitted with VL to 10 pediatric units in Andalusia (2004–2019) were retrospectively reviewed. VL diagnosis was based on clinical presentation, serology, microscopy and molecular methods. Diagnosis… Show more

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Cited by 10 publications
(18 citation statements)
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“…VL is a chronic infection caused by an intracellular protozoan parasite. It usually spread by sandflies from a domestic or a wild animal 1–4 . It is more common in tropical and subtropical areas and is more common in children <5 years of age 2,4 .…”
Section: Discussionmentioning
confidence: 99%
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“…VL is a chronic infection caused by an intracellular protozoan parasite. It usually spread by sandflies from a domestic or a wild animal 1–4 . It is more common in tropical and subtropical areas and is more common in children <5 years of age 2,4 .…”
Section: Discussionmentioning
confidence: 99%
“…It usually spread by sandflies from a domestic or a wild animal 1–4 . It is more common in tropical and subtropical areas and is more common in children <5 years of age 2,4 . It is estimated that about 50 000–90 000 new cases of VL occur world‐wide annually, with only <50% reported to World Health Organization (WHO).…”
Section: Discussionmentioning
confidence: 99%
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“…FUO can be a diagnostic challenge due to the many causes involved (table 2). In children, infections are the main aetiology (59% bacterial; 7% viral, especially Ebstein-Barr virus infection; and 10% parasitic, mainly visceral leishmaniosis in low-income countries but also in Spain) 3 4. Certain infections as tuberculosis are important in endemic areas.…”
Section: Discussionmentioning
confidence: 99%