Distinct Longitudinal Associations of MBL, MASP-1, MASP-2, MASP-3, and MAp44 With Endothelial Dysfunction and Intima–Media Thickness

Hertle, Elisabeth; Arts, Ilja C. W.; Kallen, Carla; Feskens, Edith J. M.; Schalkwijk, Casper G.; Hoffmann-Petersen, Ingeborg T.; Thiel, Steffen; Stehouwer, Coen D. A.; Greevenbroek, Marleen M.J. van

doi:10.1161/atvbaha.115.306552

Cited by 20 publications

(25 citation statements)

References 37 publications

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“…Honda et al 54 demonstrated a close relationship between endothelial dysfunction evaluated by flow-mediated dilation and vascular inflammation detected by ( 18 F)-fluorodeoxyglucosepositron emission tomography/computed tomography in subjects with mild cardiovascular risks, both of which were improved after a 6-month antihypertensive treatment. In an observational cohort study, Hertle et al 55 also showed that a number of molecules involved in the lectin-component pathway may contribute to endothelial dysfunction in subjects with mild metabolic risk factors. Furthermore, a recent meta-analysis has shown a positive association between higher serum levels of IL-1 receptor antagonist and increased incidence of cardiovascular disease in the general population.…”

Section: Hallmark Of Disease Inflammationmentioning

confidence: 99%

Endothelial Functions

Godo

Shimokawa

2017

ATVB

394

258

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e108T he endothelium plays important roles in modulating vascular tone by synthesizing and releasing an array of endothelium-derived relaxing factors, including vasodilator prostaglandins, NO, and endothelium-dependent hyperpolarization (EDH) factors, as well as endothelium-derived contracting factors.1,2 Such redundant mechanisms, like endogenous hyperglycemic hormones, are advantageous for ensuring proper maintenance of vascular tone under pathological conditions, where one of the vasoactive factor-mediated responses is compromised favoring a vasoconstrictor, prothrombotic, and proinflammatory state. Endothelial dysfunction is mainly caused by reduced production or action of endothelium-derived relaxing factors and could be an initial step toward cardiovascular disease.1 Indeed, evaluation of endothelial functions in humans has attracted much attention in the clinical settings because it serves as an excellent surrogate marker of cardiovascular events. For instance, endothelial dysfunction, as evaluated by impaired flow-mediated dilation of the brachial artery or digital reactive hyperemia index in peripheral arterial tonometry, is associated with future cardiovascular events in patients with coronary artery disease, 3-5 and 1-SD decrease in flow-mediated dilation or reactive hyperemia index is associated with doubling of cardiovascular event risk. 6 These observations suggest that endothelial function in peripheral vascular beds could predict future cardiovascular events.In this review, we will sum up the current advances and trends in the research on endothelial functions from bench to bedside with particular focus on recent publications in Arteriosclerosis, Thrombosis, and Vascular Biology. Earlier highlights of the journal on endothelial biology are extensively summarized in some review articles. 7-9 Emerging Modulators of Endothelial Functions Shear StressAs Lüscher and Corti 10 described in an editorial, flow is the signal of life. This physical force is sensed by the endothelium lining internal surface of the whole cardiovascular system to be translated into numerous downstream signaling pathways in a moment to moment manner in response to diverse physiological demands in the body. Indeed, shear stress is one of the important physiological cues that make endothelial cells synthesize and release endothelium-derived relaxing factors to cause relaxation of underlying vascular smooth muscle and vasodilatation. In this context, novel mechanisms of endothelial mechanotransduction in health and disease have been unveiled and summarized in a review series published recently in Arteriosclerosis, Thrombosis, and Vascular Biology. 11,12 Briefly, Zhou et al 12 emphasized the distinct roles of atheroprotective laminar or pulsatile shear stress versus atheroprone oscillatory shear stress or disturbed flow and discussed in detail the underlying molecular mechanisms that are dependent on these patterns of flow. Abe and Berk 11 further reviewed the current knowledge on the dual roles of shear stress with emphasis plac...

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Section: Hallmark Of Disease Inflammationmentioning

confidence: 99%

Endothelial Functions

Godo

Shimokawa

2017

ATVB

394

258

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“…The complement system has been implicated in cardiometabolic diseases, including the metabolic syndrome 47 , 61 , 62 . Complement activation is strongly associated with low-grade inflammation in the metabolic syndrome and related cardiometabolic diseases 63 – 70 . Notably, we have shown in observational studies in humans that activated complement factors are strongly associated with markers of endothelial dysfunction 64 , 65 , which are thought to reflect mainly greater microvascular endothelial dysfunction 10 .…”

Section: Novel Targets In the Metabolic Syndrome: Managing Dysfunctiomentioning

confidence: 99%

Dysfunctional adipose tissue and low-grade inflammation in the management of the metabolic syndrome: current practices and future advances

2016

Self Cite

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The ongoing worldwide obesity epidemic makes the metabolic syndrome an increasingly important entity. In this review, we provide a short background on the metabolic syndrome, we discuss recent developments in the three main options that have been identified for intervention in the metabolic syndrome, i.e. lifestyle and surgical and pharmacological interventions, and we focus on different views in the literature and also include our own viewpoints on the metabolic syndrome. In addition, we discuss some emerging treatment targets for adipose tissue dysfunction and low-grade inflammation, i.e. activation of the inflammasome and the complement system, and consider some selected opportunities for intervention in these processes.

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“…In a recent study investigating the associations of components of the lectin pathway and low-grade inflammation, endothelial dysfunction, carotid intima-media thickness and CVD, MASP-3 was associated with endothelial dysfunction, independent of plasma MBL 36 . The authors suggested a potential role through non-complement pathways.…”

Section: Discussionmentioning

confidence: 93%

Pentraxin 3, ficolin-2 and lectin pathway associated serine protease MASP-3 as early predictors of myocardial infarction - the HUNT2 study

Vengen

Enger

Videm

et al. 2017

Sci Rep

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The lectin complement pathway is suggested to play a role in atherogenesis. Pentraxin-3 (PTX3), ficolin-1, ficolin-2, ficolin-3, MBL/ficolin/collectin-associated serine protease-3 (MASP-3) and MBL/ficolin/collectin-associated protein-1 (MAP-1) are molecules related to activation of the lectin complement pathway. We hypothesized that serum levels of these molecules may be associated with the incidence of myocardial infarction (MI). In a Norwegian population-based cohort (HUNT2) where young to middle-aged relatively healthy Caucasians were followed up for a first-time MI from 1995–1997 through 2008, the 370 youngest MI patients were matched by age (range 29–62 years) and gender to 370 controls. After adjustments for traditional risk factors, the two highest tertiles of PTX3 and the highest tertiles of ficolin-2 and MASP-3 were associated with MI, with odds ratios (95% confidence interval) of 1.65 (1.10–2.47) and 2.79 (1.83–4.24) for PTX3, 1.55 (1.04–2.30) for ficolin-2, and 0.63 (0.043–0.94) for MASP-3. Ficolin-1, ficolin-3 and MAP-1 were not associated with MI. In a multimarker analysis of all associated biomarkers, only PTX3 and MASP-3 remained significant. PTX-3 and MASP-3 enhanced prediction of MI compared to the traditional Framingham risk score alone (AUC increased from 0.64 to 0.68, p = 0.006). These results support the role of complement-dependent inflammation in the pathophysiology of cardiovascular disease.

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Distinct Longitudinal Associations of MBL, MASP-1, MASP-2, MASP-3, and MAp44 With Endothelial Dysfunction and Intima–Media Thickness

Cited by 20 publications

References 37 publications

Endothelial Functions

Endothelial Functions

Dysfunctional adipose tissue and low-grade inflammation in the management of the metabolic syndrome: current practices and future advances

Pentraxin 3, ficolin-2 and lectin pathway associated serine protease MASP-3 as early predictors of myocardial infarction - the HUNT2 study

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