2024
DOI: 10.1101/2024.05.27.595950
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Distinct mechanisms of non-autonomous UPRERmediated by GABAergic, glutamatergic, and octopaminergic neurons

Aeowynn J. Coakley,
Adam Hruby,
Jing Wang
et al.

Abstract: The capacity to deal with stress declines during the aging process, and preservation of cellular stress responses is critical to healthy aging. The unfolded protein response of the endoplasmic reticulum (UPRER) is one such conserved mechanism, which is critical for the maintenance of several major functions of the ER during stress, including protein folding and lipid metabolism. Hyperactivation of the UPRERby overexpression of the major transcription factor,xbp-1s, solely in neurons drives lifespan extension a… Show more

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