Distinct neurochemical influences on fMRI response polarity in the striatum

Cerri, Domenic H.; Albaugh, Daniel L.; Walton, Lindsay R.; Katz, Brittany; Wang, Tzu-Wen; Chao, Tzu-Hao Harry; Zhang, Weiting; Nonneman, Randal J.; Jiang, Jing; Lee, Sung-Ho; Etkin, Amit; Hall, Catherine N.; Stuber, Garret D.; Shih, Yen-Yu Ian

doi:10.1038/s41467-024-46088-z

Cited by 9 publications

(1 citation statement)

References 203 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As for the underlying mechanisms explaining a dominant MD increase during inhibitory/excitatory balance, cellular shrinkage associated with neuronal hyperpolarization 9 is one possible hypothesis, while reduced trans-membrane water transport in the hyperpolarized state could be at the origin of an increase in MK. However, as suggested by a recent study focusing on the rat and human striatum 92 , the polarity of the functional response as measured by BOLD cannot be solely explained by neuronal activity subcortically, i.e. positive BOLD = excitatory activity and negative BOLD = inhibitory activity, but rather by complex neurochemical feed-forward mechanisms.…”

Section: Discussionmentioning

confidence: 90%

Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents

Hertanu,

Pavan,

Jelescu

2024

Preprint

View full text Add to dashboard Cite

Diffusion MRI (dMRI) facilitates the exploration of microstructural features within the brain owing to its sensitivity to restrictions and hindrances in the form of cell membranes or subcellular structures. As such, alterations in cell morphology and water transport mechanisms linked to neuronal activity are inherently embedded in the dMRI signal. In this context, the goal of our study was to investigate changes in Mean Diffusivity (MD) and Mean Kurtosis (MK) across the rat brain upon unilateral forepaw electrical stimulation and compare them to BOLD-fMRI mapping of brain activity. The positive BOLD response in the contralateral primary somatosensory cortex, forelimb region (S1FL) was accompanied by a significant decrease in MD in the same region, described in the literature as the result of cellular swelling and increased tortuosity in the extracellular space. For the first time, we also report a paired decrease in MK during stimulation in S1FL, most likely indicative of increased membrane permeability, as suggested by the slight decrease in exchange time estimated from kurtosis time-dependence analyses. The primary motor (M1) and the secondary somatosensory (S2) cortices, part of the cortical somatosensory processing and integration pathways, also displayed a positive BOLD response during stimulation, albeit with a lower amplitude, while MD and MK had differentiated dynamics in these two areas. In M1, the trends of MD and MK mirrored those observed in S1FL, whereas in S2, the opposite pattern was identified, that is MD and MK increased. Subcortical regions implicated in somatosensory information processing and integration, such as the thalamus and hippocampus, also exhibited an increase in MD and MK as in S2, remarkably in the absence of a discernible BOLD response. In the striatum a marginal negative BOLD response coincided with an increase in MD and MK. These findings highlight the capacity of dMRI to offer complementary functional insights into excitatory and inhibitory neural activity, potentially below the BOLD detection threshold.

show abstract

Section: Discussionmentioning

confidence: 90%

Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents

Hertanu,

Pavan,

Jelescu

2024

Preprint

View full text Add to dashboard Cite

show abstract

Neuromodulation in Small AnimalfMRI

Hsu,

Shih

2024

Magnetic Resonance Imaging

View full text Add to dashboard Cite

The integration of functional magnetic resonance imaging (fMRI) with advanced neuroscience technologies in experimental small animal models offers a unique path to interrogate the causal relationships between regional brain activity and brain‐wide network measures—a goal challenging to accomplish in human subjects. This review traces the historical development of the neuromodulation techniques commonly used in rodents, such as electrical deep brain stimulation, optogenetics, and chemogenetics, and focuses on their application with fMRI. We discuss their advantageousness roles in uncovering the signaling architecture within the brain and the methodological considerations necessary when conducting these experiments. By presenting several rodent‐based case studies, we aim to demonstrate the potential of the multimodal neuromodulation approach in shedding light on neurovascular coupling, the neural basis of brain network functions, and their connections to behaviors. Key findings highlight the cell‐type and circuit‐specific modulation of brain‐wide activity patterns and their behavioral correlates. We also discuss several future directions and feature the use of mediation and moderation analytical models beyond the intuitive evoked response mapping, to better leverage the rich information available in fMRI data with neuromodulation. Using fMRI alongside neuromodulation techniques provide insights into the mesoscopic (relating to the intermediate scale between single neurons and large‐scale brain networks) and macroscopic fMRI measures that correlate with specific neuronal events. This integration bridges the gap between different scales of neuroscience research, facilitating the exploration and testing of novel therapeutic strategies aimed at altering network‐mediated behaviors. In conclusion, the combination of fMRI with neuromodulation techniques provides crucial insights into mesoscopic and macroscopic brain dynamics, advancing our understanding of brain function in health and disease.Evidence Level1Technical EfficacyStage 1

show abstract

Evolutionarily conserved fMRI network dynamics in the mouse, macaque, and human brain

Gutierrez-Barragan,

Ramirez,

Panzeri

et al. 2024

Nat Commun

View full text Add to dashboard Cite

Evolutionarily relevant networks have been previously described in several mammalian species using time-averaged analyses of fMRI time-series. However, fMRI network activity is highly dynamic and continually evolves over timescales of seconds. Whether the dynamic organization of resting-state fMRI network activity is conserved across mammalian species remains unclear. Using frame-wise clustering of fMRI time-series, we find that intrinsic fMRI network dynamics in awake male macaques and humans is characterized by recurrent transitions between a set of 4 dominant, neuroanatomically homologous fMRI coactivation modes (C-modes), three of which are also plausibly represented in the male rodent brain. Importantly, in all species C-modes exhibit species-invariant dynamic features, including preferred occurrence at specific phases of fMRI global signal fluctuations, and a state transition structure compatible with infraslow coupled oscillator dynamics. Moreover, dominant C-mode occurrence reconstitutes the static organization of the fMRI connectome in all species, and is predictive of ranking of corresponding fMRI connectivity gradients. These results reveal a set of species-invariant principles underlying the dynamic organization of fMRI networks in mammalian species, and offer novel opportunities to relate fMRI network findings across the phylogenetic tree.

show abstract

Distinct neurochemical influences on fMRI response polarity in the striatum

Cited by 9 publications

References 203 publications

Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents

Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents

Neuromodulation in Small AnimalfMRI

Evolutionarily conserved fMRI network dynamics in the mouse, macaque, and human brain

Contact Info

Product

Resources

About