Distinct neurotoxic effects of select local anesthetics on facial nerve injury and recovery

Byram, Susanna C.; Bialek, Samantha E.; Husak, Vicki; Balcarcel, Daniel; Park, James; Dang, Jacquelyn; Foecking, Eileen M.

doi:10.3233/rnn-190987

Cited by 17 publications

(14 citation statements)

References 35 publications

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“…Some cause vasoconstriction, and although decreased flow does not automatically equal ischemia, this can theoretically further damage already compromised nerves 7‐9 . LAs have also been shown to delay functional recovery after nerve injury in animal models 10 . While application of basic science to clinical situations does not always capture all contributing factors, given these findings, we must approach the use of LAs in these vulnerable patients with a healthy dose of caution.…”

Section: Introductionmentioning

confidence: 99%

Regional anesthesia in pediatric patients with preexisting neurological disease

Cung

Ritz

Masaracchia

2021

Pediatric Anesthesia

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Preexisting neurological disease in pediatric patients presents unique challenges to the anesthesiologist. In‐depth knowledge of the disease processes and awareness of sequalae that uniquely influence the risks and benefits of anesthetics are needed to make informed decisions. Because these vulnerable populations are often susceptible to perioperative airway or cardiopulmonary complications, the use of regional anesthesia can be advantageous. However, these clinical conditions already involve compromised neural tissue and, as such, create additional concern that regional anesthesia may result in new or worsened deficits. The following discussion is not intended to be a full review of each disease process, but rather provides a concise, yet thorough, discussion of the available literature on regional anesthesia in the more common, but still rare, pediatric neurological disorders. We aim to provide a framework for pediatric anesthesiologists to reengage in a healthy discussion about the risks and benefits of utilizing regional anesthesia in this vulnerable population.

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Section: Introductionmentioning

confidence: 99%

Regional anesthesia in pediatric patients with preexisting neurological disease

Cung

Ritz

Masaracchia

2021

Pediatric Anesthesia

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“…Some experiments have also demonstrated that ropivacaine induces neurotoxicity after long-term exposure to ropivacaine at a high concentration [22][23][24] . Since Yamashita et al rst reported the neurotoxicity of ropivacaine [25] , many studies have been conducted to explore and compare the neurotoxicity of LAs commonly used in clinical practice, including lidocaine, and bupivacaine [26,27] . Although it had been reported that ropivacaine has the least neurotoxicity among the LAs tested, increasing attention has been paid to the safety of ropivacaine [25] .…”

Section: Discussionmentioning

confidence: 99%

Ropivacaine induces cell cycle arrest in the G0/G1 phase and apoptosis of PC12 cells via inhibiting mitochondrial STAT3 translocation

Zeng

Zhang

et al. 2021

Preprint

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STAT3 has neuroprotective effect via non-canonical activation and mitochondrial translocation, but its effects on ropivacaine-induced neurotoxicity remain unclear. Our previous study revealed that apoptosis was an important mechanism of ropivacaine-induced neurotoxicity, this study is to illustrate the relationship between STAT3 with ropivacaine-induced apoptosis. Those results showed that ropivacaine treatment decreased cell viability, induced cell cycle arrest in the G0/G1 phase, apoptosis, oxidative stress, and mitochondrial dysfunction in PC12 cells. Besides, ropivacaine decreased the phosphorylated levels of STAT3 at Ser727 and downregulated the expression of STAT3 upstream gene IL-6. The mitochondrial translocation of STAT3 was also hindered by ropivacaine. To further illustrate the connection of STAT3 protein structure with ropivacaine, the autodock-vina was used to examine the interaction between STAT3 and ropivacaine, and the results showed that ropivacaine could bind to STAT3’s proline site and other sites. In addition, the activator and inhibitor of mitoSTAT3 translocation were used to demonstrate it was involved in ropivacaine-induced apoptosis, the results showed that enhancing the mitochondrial STAT3 translocation could prevent ropivacaine-induced apoptosis. Finally, the expression of p-STAT3 and the levels of apoptosis in the spinal cord were also detected, the results were consistent with the cell experiment, ropivacaine decreased the expression of p-STAT3 protein and increased the levels of apoptosis in the spinal cord. We demonstrated that ropivacaine induced apoptosis by inhibiting the phosphorylation of STAT3 at Ser727 and the mitochondrial STAT3 translocation. This effect was reversed by the activation of the mitochondrial STAT3 translocation.

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“…Patients who have undergone a complete examination by anesthetics might reveal many other problems. In selecting patients for undergoing elective surgeries, eliciting their previous anesthesia toxicity, which has not been perceived initially, must be noted and taken under consideration during pandemic COVID-19 [13]. Other patients' necessary consultations, in cases suspicious of any types of infections in the past and present times, should be utilized for candidates of elective surgeries [14].…”

Section: Introduction Oronavirus Disease 2019 (Covid-19mentioning

confidence: 99%

Elective Surgery Guidelines During COVID-19 Pandemic: A Current Literature Review

Shemshadi

Layeghi

Khorasani

2021

HDQ

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Background: The primary purpose of this literature review is to investigate different views of elective surgery management during the COVID-19 pandemic. In other words, the guidelines about diseases prevention and their proper management during performing elective surgeries have been reviewed. Materials and Methods: Current articles related to COVID-19 and practicing elective surgeries in different remarkable EndNote X8 database journals in 2020 were retrieved. All articles referring to COVID-19 precaution rules in implementing elective surgeries were integrated into the article’s main goals. Results: All reviews showed alarming guideline steps that should be taken for validated preventing and managing elective surgeries practiced during the COVID-19 pandemic. Emphasizing qualified elective surgery protocols were quoted in many articles to do elective surgeries with successful results. Conclusion: Taking effective and evidence-based steps in patients` selection, precautions, and hospitals` safety cares result in protective surgical results. Elective surgeries should be practiced in highly-equipped hospitals with extraordinary quarantine measures during a COVID-19 pandemic. Safety measures are the primary goal for patients, staff, surgeons, and other health providers before surgeons get involved with any elective surgeries during the COVID-19 pandemic. Questions of how different elective surgical operations are planned during the COVID-19 pandemic are essential controversies. As no clear answers are found to questions of how elective surgeries can be practiced during a COVID-19 pandemic, specific rules issued by the world’s most authentic surgical associations have been adopted by surgeons to operate elective surgeries.

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Distinct neurotoxic effects of select local anesthetics on facial nerve injury and recovery

Cited by 17 publications

References 35 publications

Regional anesthesia in pediatric patients with preexisting neurological disease

Regional anesthesia in pediatric patients with preexisting neurological disease

Ropivacaine induces cell cycle arrest in the G0/G1 phase and apoptosis of PC12 cells via inhibiting mitochondrial STAT3 translocation

Elective Surgery Guidelines During COVID-19 Pandemic: A Current Literature Review

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