Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease

Hirschmann, Jan V.; Özkurt, Tolga Esat; Butz, Markus; Homburger, M.; Elben, Saskia; Hartmann, Christian; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons

doi:10.1016/j.neuroimage.2010.11.063

Cited by 212 publications

(179 citation statements)

References 58 publications

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“…The use of medication, such as levodopa, e ectively suppresses beta activity in the above areas and strongly correlates with clinical improvement [53]. Additionally, coherence in the beta-band has been shown to provide a mechanism to couple the sensorimotor system with peripheral systems such as spinal cord and muscles [48,[54][55][56][57].…”

Section: Beta Oscillations In Sensorimotor Areas During Movement Execmentioning

confidence: 99%

Beta oscillations and their functional role in movement perception

Pavlidou¹,

Schnitzler

Lange

2014

Translational Neuroscience

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Neuronal oscillations are a ubiquitous phenomenon observed in multiple cortical and subcortical areas across a wide range of species [1]. Neuronal oscillations are often generated in neuronal networks that in uence each other via excitatory and inhibitory connections. As a result, neurons are rhythmically stimulated and inhibited [2]. Neuronal oscillations have been described on several levels, ranging from single cells to cell assemblies of several thousand neurons. Accordingly, several methods exist to measure neuronal oscillations. On the level of single cells or small cell assemblies neuronal oscillations can be measured invasively by single cell or multi-unit recordings. If thousands of neurons oscillate synchronously, the resulting signal might be strong enough to be recorded non-invasively outside the skull using electroencephalography (EEG) and magnetoencephalography (MEG) [3,4].Using EEG, the first to observe such rhythmic fluctuations non-invasively in the living human brain was Hans Berger [5]. In his seminal work, he first described rhythmic patterns in the EEG in the 8-12 Hz range; the famous alpha waves.Since then, investigators have revealed a wide range of oscillatory activity in several di erent frequency bands ranging from slow (0.1 Hz) to ultra-fast (~ 500 Hz) oscillations [4].Neuronal oscillations can be found in local neuronal groups, but oscillations have also been suggested as a mechanism for long-range communication between neuronal groups. Long-range communication is a process in which one area transfers certain characteristics of its current functional state to another area [6] or in which spatially distinct cortical areas are bound to one functional network [7]. In general, high frequencies are believed to re ect neuronal activity over small spatial regions and short temporal windows, while low frequencies are believed to modulate activity over large spatial regions and long temporal windows [8,9]. These relations between spatial and temporal patterns allow brain processes to be carried out simultaneously at multiple spatial and temporal scales [10][11][12].Neuronal oscillations have been classified in mainly five distinct frequency bands: delta (1.5-4 Hz), theta (5-7 Hz), alpha (8-12 Hz), beta (13-29 Hz) and gamma . Within the same neuronal network each frequency band is usually associated with di erent cognitive states [13] or sensory, motor and cognitive processes [14][15][16][17][18][19][20]. Delta oscillations are often seen during deep sleep, but recently they have also been linked to cognitive functions such as motivational and reward processes [21][22][23].Theta-band is often associated with working memory [24,25], while alpha oscillations have been suggested to re ect cortical idling states [26]. In recent years however, the role of alpha oscillations has also been linked to active inhibition [27] as well as cortical excitability [28][29][30]. Oscillations in the beta-band have been more characteristically related to sensorimotor functions [31,32], whilst gamma oscillations ha...

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Section: Beta Oscillations In Sensorimotor Areas During Movement Execmentioning

confidence: 99%

Beta oscillations and their functional role in movement perception

Pavlidou¹,

Schnitzler

Lange

2014

Translational Neuroscience

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“…Interestingly, this coupling can be successfully reduced by dopamine replacement therapy (Salenius et al, 2002;Pollok et al, 2009). Simultaneous recordings using MEG and local field potentials in the subthalamic nucleus (STN) reveal that and activities are coupled to temporal brain areas and are involved in a functional separation of basal ganglia-cortex loops with different frequency patterns (Hirschmann et al, 2011). Litvak et al (2011) reported that in PD patients at rest, -range activities are coupled with temporoparietalbrainstem areas while -range activities are coupled with the frontal network.…”

Section: Magnetoencephalography (Meg)mentioning

confidence: 99%

Thalamic Deep Brain Stimulation for Parkinson’s Disease

Morigaki¹,

Saijo²,

Kaji³

et al. 2011

Diagnosis and Treatment of Parkinson's Disease

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“…PD patients without DBS would have had to endure a full night and half a day off dopaminergic medication, which would have been a challenging task for these patients (matched on disease progression with the DBS cohort), compared to which patients in our cohort had to endure ~2 hours in the completely untreated condition under the supervision of a movement disorders specialist. One alternative to complete withdrawal overnight for PD patients without DBS would have been to keep the patients under subcutaneous medication (apomorphine) (Hirschmann et al, 2011(Hirschmann et al, , 2013 for 12-24 hours prior to the experiment, but this would still have been a drastic intervention in the patients' well-being when they would "merely" serve as control patients.…”

Section: Control Groupmentioning

confidence: 99%

“…There is substantial work on the mechanism of DBS and the possible neural networks and circuits that DBS influences using animal studies (Chomiak and Hu, 2007;Li et al, 2007;Gradinaru et al, 2009) as well as intra-operative and post-operative human studies (Airaksinen et al, 2011;Hirschmann et al, 2011Hirschmann et al, , 2013Walker et al, 2012;de Hemptinne et al, 2015).…”

Section: Effect-mechanisms Of Dbsmentioning

confidence: 99%

“…They have showed varied effects of treatments (Abbruzzese and Berardelli, 2003;Conte et al, 2013;Patel et al, 2014), triggering electrophysiological investigations on changes in the cortical and sub-cortical structures during motor tasks (Salenius et al, 2002;Brücke et al, 2008;Hirschmann et al, 2011Hirschmann et al, , 2013 Introduction Introduction suffers from methodological issues (Salenius et al, 2002;Park et al, 2009;Hirschmann et al, 2013;Airaksinen et al, 2015;Cao et al, 2015Cao et al, , 2017Oswal et al, 2016). …”

Section: Chapter -1 Introductionmentioning

confidence: 99%

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Neuromagnetic investigations of mechanisms and effects of STN-DBS and medication in Parkinson's disease

Sridharan¹

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Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease

Cited by 212 publications

References 58 publications

Beta oscillations and their functional role in movement perception

Beta oscillations and their functional role in movement perception

Thalamic Deep Brain Stimulation for Parkinson’s Disease

Neuromagnetic investigations of mechanisms and effects of STN-DBS and medication in Parkinson's disease

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