Distinct osteogenic effect of different periosteum derived cells via Hippo-YAP cascade signaling

Tang, Yufei; Wu, Bingfeng; Liu, Jiayi; Long, Hu; Wei, Lai; Lin, Xiang

doi:10.1080/15384101.2022.2111768

Cited by 3 publications

(2 citation statements)

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“…Interestingly, the downregulation of YAP enhanced the ALP activity, the related genes’ mRNA expression, and the calcium deposits of femoral PSCs, while inhibiting those characteristics in mandibular PSCs in vitro. Mandibular PSCs also demonstrated superior bone repair in both mandible and femoral defect models, likely due to their different embryonic origins and modes of bone formation [ 125 ].…”

Section: Periosteal Stem Cells (Pscs)mentioning

confidence: 99%

Stem Cells and Bone Tissue Engineering

Gao,

Ruzbarsky,

Layne

et al. 2024

Life

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Segmental bone defects that are caused by trauma, infection, tumor resection, or osteoporotic fractures present significant surgical treatment challenges. Host bone autograft is considered the gold standard for restoring function but comes with the cost of harvest site comorbidity. Allograft bone is a secondary option but has its own limitations in the incorporation with the host bone as well as its cost. Therefore, developing new bone tissue engineering strategies to treat bone defects is critically needed. In the past three decades, the use of stem cells that are delivered with different scaffolds or growth factors for bone tissue engineering has made tremendous progress. Many varieties of stem cells have been isolated from different tissues for use in bone tissue engineering. This review summarizes the progress in using different postnatal stem cells, including bone marrow mesenchymal stem cells, muscle-derived stem cells, adipose-derived stem cells, dental pulp stem cells/periodontal ligament stem cells, periosteum stem cells, umbilical cord-derived stem cells, peripheral blood stem cells, urine-derived stem cells, stem cells from apical papilla, and induced pluripotent stem cells, for bone tissue engineering and repair. This review also summarizes the progress using exosomes or extracellular vesicles that are delivered with various scaffolds for bone repair. The advantages and disadvantages of each type of stem cell are also discussed and explained in detail. It is hoped that in the future, these preclinical results will translate into new regenerative therapies for bone defect repair.

show abstract

Section: Periosteal Stem Cells (Pscs)mentioning

confidence: 99%

Stem Cells and Bone Tissue Engineering

Gao,

Ruzbarsky,

Layne

et al. 2024

Life

View full text Add to dashboard Cite

show abstract

“…Interestingly, the downregulation of YAP enhanced the ALP activity, related gene's mRNA expression, and calcium deposits of femoral PSCs, while inhibiting those characteristics in mandibular PSCs in vitro. Mandibular PSCs also demonstrated superior bone repair in both mandible and femoral defect models, likely due to their different embryonic origins and modes of bone formation [123].…”

Section: Pscs From Different Anatomic Origins Demonstrate Variable Bo...mentioning

confidence: 99%

Stem Cells and Bone Tissue Engineering

Gao,

Ruzbarsky,

Layne

et al. 2024

Preprint

View full text Add to dashboard Cite

Segmental bone defects caused by trauma, infection, tumor resection or osteoporotic fractures present significant surgical treatment challenges. Host bone autograft is considered the gold standard to restore function but comes with the cost of harvest site comorbidity. Allograft bone is a secondary option but has its own limitations in incorporation with host bone as well as cost. Therefore, developing new bone tissue engineering strategies to treat bone defects is critically needed. In the past three decades, the use of stem cells delivered with different scaffolds or growth factors for bone tissue engineering has made tremendous progress. Many varieties of stem cells have been isolated from different tissues for use in bone tissue engineering. This review summarizes the progress in using different postnatal stem cells including bone marrow mesenchymal stem cells, muscle-derived stem cells, adipose-derived stem cells, dental pulp stem cells/periodontal ligament stem cells, periosteum stem cells, umbilical cord-derived stem cells, peripheral blood stem cells and urine-derived stem cells for bone tissue engineering and repair. This review also summarizes the progress using exosomes or extracellular vesicles delivered with various scaffolds for bone repair. The advantages and disadvantages of each type of stem cell are also discussed and explained in detail. It is hopeful in the future that these preclinical results will translate into new therapies for bone defect repair.

show abstract