Distinct Recurrence Pattern and Outcome of Adenocarcinoma of the Gastric Cardia in Comparison with Carcinoma of Other Regions of the Stomach

Saito, Hiroaki; Fukumoto, Yoshihiro; Osaki, Tomohiro; Fukuda, Kenji; Tatebe, Shigeru; Tsujitani, Shunichi; Ikeguchi, Masahide

doi:10.1007/s00268-005-0582-z

Cited by 91 publications

(64 citation statements)

References 15 publications

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“…This difference in survival is confirmed by other studies, although prognosis in the East is still far better with a 5-year survival of 62%. 4,24 Gastric carcinoma can be divided into two distinct histological patterns, a diffuse and an intestinal type according to the Laurè n classification. 25 In the last decades, a rise in the incidence of diffuse type of carcinoma is seen worldwide.…”

Section: Discussionmentioning

confidence: 99%

Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands

Dassen¹,

Lemmens²,

Poll‐Franse³

et al. 2010

European Journal of Cancer

137

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General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.-Users may download and print one copy of any publication from the public portal for the purpose of private study or research -You may not further distribute the material or use it for any profit-making activity or commercial gain -You may freely distribute the URL identifying the publication in the public portal Take down policyIf you believe that this document breaches copyright, please contact us providing details, and we will remove access to the work immediately and investigate your claim. Conclusion:The absence of improvement in survival rates indicates the need for earlier detection and prospective studies to evaluate new therapy regimens with standardised surgery and pathology.

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Section: Discussionmentioning

confidence: 99%

Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands

Dassen¹,

Lemmens²,

Poll‐Franse³

et al. 2010

European Journal of Cancer

137

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“…A statistically significant finding could be noted in intestinal-type but not in sporadic diffuse-type cancer (GG-plus-GA vs. AA). As is known, cardia-type gastric cancer differs from noncardia-type gastric cancer in etiology, pathology, carcinogenesis, and/or prognosis (Heidl et al, 1993;Kim et al, 2005;Saito et al, 2006), so is intestinal-type cancer versus sporadic diffuse-type cancer. It could be said that the indiscriminate combination of cardia-type and noncardia-type cases or intestinal-type and diffuse-type cases in the majority of eligible studies may mask or at least underestimate the strength of the real associations (Xue et al, 2010Cui et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of Interleukin-10-1082 Promoter Polymorphism Associated with Gastric Cancer Risk

Han

et al. 2012

DNA and Cell Biology

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“…Though we cannot explain the differences, the prognosis of tumors in the lower third of stomach is better than that in any other locations of stomach [16][17][18] . We presume that the prognosis of gastric cancer is associated with the metastasis of gastric cancer cells into the vagina vasorum.…”

Section: Discussionmentioning

confidence: 99%

Vagina vasorum dissection during D2 lymphadenectomy for gastric carcinoma

Peng¹

2007

WJG

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AIM:To explore the relationship between metastasis and vagina vasorum in the progress of gastric carcinoma and to find some facts and references for gastric surgeons. METHODS:One hundred and seven specimens of left or right gastric arteries (55 left and 52 right) were gathered from 59 patients undergoing radical gastrectomy for gastric carcinoma. All the frozen specimens were cut into 3 μm-thick sections and stained with hematoxylineosin (HE) and immunohistochemical method separately. Cytokeratin (CK) and mesothelial cells (MC) were stained with immunohistochemical method. Cancer cells inside vagina vasorum were detected and the structure of artery wall was observed under microscope. RESULTS:Metastatic cancer cells or tubercles were found inside vagina vasorum in some stage Ⅲ or Ⅳ specimens, but not in stageⅠor Ⅱ specimens. Tumor cells in vagina vasorum were CK positive in 26 specimens of 14 tumors. Among them, stage Ⅲ was found in 4 specimens of 2 tumors, and stage Ⅳ in 22 specimens of 12 tumors. None of these specimens was positive for MC. The positive rate of CK increased with TNM staging. Compared with the lower part, tumors in the upper and middle parts of stomach were more likely to metastasize into vagina vasorum.CONCLUSION: Vagina vasorum dissection should be performed during D2 lymphadenectomy for TNM stage Ⅲ or Ⅳ gastric carcinoma.

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Distinct Recurrence Pattern and Outcome of Adenocarcinoma of the Gastric Cardia in Comparison with Carcinoma of Other Regions of the Stomach

Abstract: Our data indicate that the prognosis of patients with adenocarcinoma of the gastric cardia is extremely poor. To improve their prognosis, new treatments in addition to gastrectomy with extensive lymph node dissection are needed.

Cited by 91 publications

References 15 publications

Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands

Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands

A Meta-Analysis of Interleukin-10-1082 Promoter Polymorphism Associated with Gastric Cancer Risk

Vagina vasorum dissection during D2 lymphadenectomy for gastric carcinoma

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