Distinct reward processing by subregions of the nucleus accumbens

Chen, Gaowei; Lai, Shishi; Bao, Guo Bin; Ke, Jincan; Meng, Xiaogao; Shen, Lu; Wu, Xiaocong; Xu, Hua; Wu, Fengyi; Xu, Yuehua; Xu, Fang; Bi, Guoqiang; Peng, Guangdun; Zhou, Kai; Zhu, Ying‐Jie

doi:10.1016/j.celrep.2023.112069

Cited by 27 publications

(22 citation statements)

References 85 publications

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“…Interestingly, both neuronal populations decrease activity during the US period across learning, in accordance with electrophysiological data showing that a large portion of NAc neurons decrease activity during reward delivery (Carelli, 2004;Janak et al, 2004;Roitman et al, 2005). In a recent study using calcium imaging recordings with miniaturized microscopes, it was found that reward consumption increased NAc lateral subregion activity but decreased medial subregion activity (Chen et al, 2023).…”

Section: Discussionsupporting

confidence: 79%

“…Indeed, a study using miniaturized microscopes to monitor single cell activity in the NAc with calcium indicators in the medial and lateral shell shows distinct types of responses to unexpected rewards (water) in both D1-and D2-MSNs (Chen et al, 2023). This approach or electrophysiological recordings with optotagging of D1-or D2-neurons would be very interesting to perform in animals during appetitive and aversive Pavlovian conditioning to better understand the contribution of these neurons for these processes.…”

Section: Discussionmentioning

confidence: 99%

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Nucleus accumbens neurons dynamically encode positive and aversive associative learning

Deseyve

Domingues

Carvalho

et al. 2023

Preprint

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To survive, individuals must learn to associate cues in the environment with emotionally relevant outcomes. This association is partially mediated by the nucleus accumbens (NAc), a key brain region of the reward circuit that is mainly composed by GABAergic medium spiny neurons (MSNs), that express either dopamine receptor D1 or D2. Recent studies showed that both populations can drive reward and aversion, however, the activity of these neurons during appetitive and aversive Pavlovian conditioning remains to be determined. Here, we investigated the relevance of D1- and D2-neurons in Pavlovian associations, by measuring calcium transients with fiber photometry during appetitive and aversive Pavlovian tasks. Sucrose was used as a positive unconditioned stimulus (US) and foot shock was used as a negative US. We show that during appetitive Pavlovian conditioning, D1- and D2-neurons exhibit a general decrease in activity in response to CS and to US across learning, with dynamic, and partially overlapping, activity responses to CS and US. During the aversive Pavlovian conditioning, D1- and D2-neurons showed an increase in the activity in response to the CS and to the US (shock). Our data supports a synchronous role for D1- and D2-neurons in appetitive and aversion processing.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Nucleus accumbens neurons dynamically encode positive and aversive associative learning

Deseyve

Domingues

Carvalho

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…[ 48 ] Natural flavonoids, including luteolin, can also be utilized as a therapeutic candidate with anti‐inflammatory and antioxidative action for the treatment of AMD by inhibiting epithelial‐mesenchymal transition, which is known to be associated with AMD progression. [ 49 ] Recently, various studies have been reported to develop nanoparticles that not only reduce ROS levels but also have anti‐inflammatory effects for the treatment of AMD. Polydopamine nanoparticles carrying a heme‐albumin protein complex exhibited potent antioxidant ROS scavenging abilities and anti‐inflammatory effects in LPS‐ and/or H 2 O 2 ‐stimulated hRPEs, primarily due to the intrinsic characteristics of polydopamine and the upregulation of heme oxygenase‐1 expression resulting from the sustained release of the heme‐albumin complex.…”

Section: Resultsmentioning

confidence: 99%

Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age‐Related Macular Degeneration

Choi,

Kim,

Kim

2023

Advanced NanoBiomed Research

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Age‐related macular degeneration (AMD), the leading cause of vision loss among older individuals, is characterized by damage to photoreceptors and retinal pigment epithelial cells (RPEs). Oxidative stress and chronic inflammation in the retina play notable roles in AMD pathogenesis, rendering them attractive therapeutic targets. Cerium oxide nanoparticles (CeNPs) have shown promise in scavenging reactive oxygen species (ROS) by mimicking antioxidant enzymes, whereas mesoporous materials have emerged as versatile drug carriers. Herein, mesoporous CeNPs (mCeNPs) that integrate the advantages of CeNPs and mesoporous materials are presented. The mCeNPs can be synthesized using 1,1′‐carbonyldiimidazole and imidazole in acetone without heating and pressurization. The resulting mCeNPs exhibit mesoporous structures comprising assembled small CeNPs, exerting excellent ROS‐scavenging capabilities, biocompatibility, and cytoprotective and anti‐inflammatory effects against H2O2‐induced damage in RPEs. Using a sodium iodate‐induced AMD mouse model, it is demonstrated that intravitreal mCeNP administration can exhibit disease‐preventive effects. These findings indicate the therapeutic potential of mCeNPs against AMD.

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“…Considering recent single‐cell RNA sequencing data, at least 18 MSN sub‐types exist in the NAc (Chen et al., 2021), suggesting that even within D1‐ and D2‐neurons, functional sub‐populations co‐exist. Indeed, a study using miniaturized microscopes to monitor single cell activity with calcium indicators in the medial and lateral NAc shell shows distinct types of responses to unexpected rewards (water) in both D1‐ and D2‐MSNs (Chen et al., 2023). This approach or electrophysiological recordings with optogenetic tagging of D1‐ or D2‐neurons would be very interesting to perform in animals during appetitive and aversive Pavlovian conditioning to better understand the contribution of these neurons for these processes.…”

Section: Discussionmentioning

confidence: 99%

Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning

Deseyve,

Domingues,

Carvalho

et al. 2024

Journal of Neurochemistry

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To survive, individuals must learn to associate cues in the environment with emotionally relevant outcomes. This association is partially mediated by the nucleus accumbens (NAc), a key brain region of the reward circuit that is mainly composed by GABAergic medium spiny neurons (MSNs), that express either dopamine receptor D1 or D2. Recent studies showed that both populations can drive reward and aversion, however, the activity of these neurons during appetitive and aversive Pavlovian conditioning remains to be determined. Here, we investigated the relevance of D1‐ and D2‐neurons in associative learning, by measuring calcium transients with fiber photometry during appetitive and aversive Pavlovian tasks in mice. Sucrose was used as a positive valence unconditioned stimulus (US) and foot shock was used as a negative valence US. We show that during appetitive Pavlovian conditioning, D1‐ and D2‐neurons exhibit a general increase in activity in response to the conditioned stimuli (CS). Interestingly, D1‐ and D2‐neurons present distinct changes in activity after sucrose consumption that dynamically evolve throughout learning. During the aversive Pavlovian conditioning, D1‐ and D2‐neurons present an increase in the activity in response to the CS and to the US (shock). Our data support a model in which D1‐ and D2‐neurons are concurrently activated during appetitive and aversive conditioning.

show abstract

Distinct reward processing by subregions of the nucleus accumbens

Cited by 27 publications

References 85 publications

Nucleus accumbens neurons dynamically encode positive and aversive associative learning

Nucleus accumbens neurons dynamically encode positive and aversive associative learning

Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age‐Related Macular Degeneration

Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning

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