Distinct Roles of Calcineurin-Nuclear Factor of Activated T-Cells and Protein Kinase A-cAMP Response Element-Binding Protein Signaling in Presynaptic Differentiation

Yoshida, Tomoyuki; Mishina, Masayoshi

doi:10.1523/jneurosci.3738-04.2005

Cited by 40 publications

(64 citation statements)

References 80 publications

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“…Expression in the nervous system is still most evident in the olfactory epithelium and cerebellum ( Fig. 3C), where neurons are undergoing activity-dependent survival and maturation (Yoshida and Mishina, 2005;Volkmann et al, 2008). In contrast, expression appears diminished in the midbrain and hindbrain (Fig.…”

Section: Cabin1 Is Expressed In the Developing Nervous Systemmentioning

confidence: 98%

“…Specifically, Cabin1 expression is apparent in the forebrain, midbrain, hindbrain, and retina at times previously correlated with the presence of differentiated neurons in the process of forming mature connections (Table 1). In the olfactory and retinotectal systems in particular, Cabin1 expression correlates with times when neurons in these regions have previously been determined to undergo synaptogenesis and synaptic refinement (Stuermer, 1988;Yoshida and Mishina, 2005). To identify possible molecular pathways with which Cabin1 might interact during these periods of CNS development, we compared the developmental gene expression patterns of known interacting partners calcineurin and MEF2.…”

Section: Cabin1 Is Expressed In the Developing Nervous Systemmentioning

confidence: 99%

“…Calcineurin phosphatase activity is required for NFAT (nuclear factor of activated T cells) -mediated transcription. While the ability of Cabin1 to repress these transcriptional pathways has not been tested in neurons, calcineurin-NFAT and MEF2 transcriptional pathways have been implicated in differentiation (Okamoto et al, 2000), neuronal survival Groth and Mermelstein, 2003;Shalizi et al, 2003;Pazyra-Murphy et al, 2009), and synaptogenesis (Yoshida and Mishina, 2005;Flavell et al, 2006;Shalizi et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Based on the requirements of calcineurin-mediated and MEF2 transcription for normal nervous system development, including such calciumdependent processes as synaptic remodeling (Yoshida and Mishina, 2005) and activity-dependent survival , we predict Cabin1 may play important roles in the development of the nervous system by repressing the transcriptional activity of calcineurin-NFAT and MEF2. Here, we establish that Cabin1 is prominently expressed in the developing nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Cabin1 expression suggests roles in neuronal development

Hammond

Udvadia

2010

Developmental Dynamics

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*Nervous system assembly and function depends on precise regulation of developmental gene expression. Cabin1, an essential gene in developing mice, is enriched in regions of the developing zebrafish central nervous system (CNS). Cabin1 is a repressor of MEF2-(myocyte enhancer factor 2) and calcineurin-mediated transcription in the immune system, but its function in the CNS during development is unknown. We identified Cabin1 from a library of genes enriched in developing neurons and determined the temporal and spatial expression of Cabin1 mRNA during CNS development. We found Cabin1 mRNA expression in the developing brain at times correlated with later aspects of neuronal differentiation. In some regions of the CNS Cabin1 expression overlaps with regions that also express proteins known to interact with Cabin1: MEF2 and/or calcineurin. We suggest that Cabin1 could act as a regulator of MEF2 and calcineurin activity in the developing nervous system, given their roles in neuronal differentiation and synaptic refinement. Developmental Dynamics 239:2443-2451,

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Section: Cabin1 Is Expressed In the Developing Nervous Systemmentioning

confidence: 98%

Section: Cabin1 Is Expressed In the Developing Nervous Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cabin1 expression suggests roles in neuronal development

Hammond

Udvadia

2010

Developmental Dynamics

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“…It is also possible that CREB and NFAT regulate different molecular events that coordinate to regulate axon growth. Indeed, it has been shown recently that during presynaptic differentiation, CREB and NFAT respectively regulate synaptic vesicle accumulation and axon terminal remodelling, both of which are important events for synaptogenesis during development (Yoshida & Mishina 2005).…”

Section: Genetic Control Of Axon Growthmentioning

confidence: 99%

Intracellular control of developmental and regenerative axon growth

Zhou

Snider

2006

Phil. Trans. R. Soc. B

174

138

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Axon growth is a highly regulated process that requires stimulating signals from extracellular factors. The extracellular signals are then transduced to regulate coordinately gene expression and local axon assembly. Growth factors, especially neurotrophins that act via receptor tyrosine kinases, have been heavily studied as extracellular factors that stimulate axon growth. Downstream of receptor tyrosine kinases, recent studies have suggested that phosphatidylinositol-3 kinase (PI3K) regulates local assembly of axonal cytoskeleton, especially microtubules, via glycogen synthase kinase 3b (GSK-3b) and multiple microtubule binding proteins. The role of extracellular signal regulated kinase (ERK) signalling in regulation of local axon assembly is less clear, but may involve the regulation of local protein translation. Gene expression during axon growth is regulated by transcription factors, among which cyclic AMP response element binding protein and nuclear factors of activated T-cells (NFATs) are known to be required for neurotrophin (NT)-induced axon extension. In addition to growth factors, extracellular matrix molecules and neuronal activity contribute importantly to control axon growth. Increasingly, evidence suggests that these influences act to enhance growth via coordinating with growth factor signalling. Finally, evidence is emerging that developmental versus regenerative axon growth may be mediated by distinct signalling pathways, both at the level of gene transcription and at the level of local axon assembly.

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The calcineurin—nuclear factor of activated T cells signaling pathway mediates the effect of corticotropin releasing factor and urocortins on catecholamine synthesis

Dermitzaki

Tsatsanis

Gravanis

et al. 2012

Journal Cellular Physiology

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The biological effects of the Corticotropin-releasing factor (CRF) family of neuropeptides are mediated by mobilization of [Ca(2+)]. Aim of the current work was to examine if the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway is involved in the effect of CRF peptides in catecholamine synthesis and secretion from PC12 rat pheochromocytona cells, a model for the study of adrenal catecholamine production. PC12 cells express both types of CRF receptors. Our data are as follows: (a) The calcineurin inhibitor cyclosporine A (CsA) blocked norepinephrine secretion induced by ligands of either CRF type 1 (CRF(1)) or 2 (CRF(2)) receptors on PC12 cells. (b) Silencing NFAT2 expression using a selective NFAT2 siRNA blocked CRF(1) and CRF(2) -induced NE production. (c) CRF ligands induced NFAT transcriptional activity in cells transfected with a luciferase reporter construct controlled by NFAT binding elements (NFAT-Luc). (d) CsA completely blocked the stimulatory effect of CRF(1) and CRF(2) ligands on NFAT activity in NFAT-Luc transfected cells. (e) PKA, PKC, p38-MAPK, Tpl2, Ha-Ras, and AKT1 were crucial intermediates for both CRF(1) and CRF(2)-induced NFAT activation. Interestingly, MEK1/2 and ERK1/2 were crucial only for the CRF(2)-induced NFAT activation. (f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production. In conclusion, our data suggest that CRF(1) and CRF(2) ligands activate the transcription factor NFAT and its activation is prerequisite for CRF-induced catecholamine production from chromaffin cells.

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Distinct Roles of Calcineurin-Nuclear Factor of Activated T-Cells and Protein Kinase A-cAMP Response Element-Binding Protein Signaling in Presynaptic Differentiation

Cited by 40 publications

References 80 publications

Cabin1 expression suggests roles in neuronal development

Cabin1 expression suggests roles in neuronal development

Intracellular control of developmental and regenerative axon growth

The calcineurin—nuclear factor of activated T cells signaling pathway mediates the effect of corticotropin releasing factor and urocortins on catecholamine synthesis

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