Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization

Brodovskaya, Anastasia; Batabyal, Tamal; Shiono, Shinnosuke; Sun, Huayu

doi:10.1002/ana.26338

Cited by 12 publications

(15 citation statements)

References 47 publications

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“…The mediating role of the thalamus in cortico-cortical communication in seizures that secondarily generalise has been analysed in rodent [52] and human [53, 11] studies. Reduced basal ganglia–thalamus network interaction is suggested to increase the propensity for secondary generalisation [53, 54].…”

Section: Discussionmentioning

confidence: 99%

Deep learning distinguishes focal epilepsy groups using connectomes: Feasibility and clinical implications

Maher

Tang

D’Souza

et al. 2023

Preprint

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The application of deep learning models to evaluate connectome data is gaining interest in epilepsy research. Deep learning may be a useful initial tool to partition connectome data into network subsets for further analysis. Few prior works have used deep learning to examine structural connectomes from patients with focal epilepsy. We evaluated whether a deep learning model applied to whole-brain connectomes could classify 28 participants with focal epilepsy from 20 controls and identify nodal importance for each group. Participants with epilepsy were further grouped based on whether they had focal seizures that evolved into bilateral tonic-clonic seizures (17 with, 11 without). The trained neural network classified patients from controls with an accuracy of 72.92%, while the seizure subtype groups achieved a classification accuracy of 67.86%. In the patient subgroups, the nodes and edges deemed important for accurate classification were also clinically relevant, indicating the model's interpretability. The current work expands the evidence for the potential of deep learning to extract relevant markers from clinical datasets. Our findings offer a rationale for further research interrogating structural connectomes to obtain features that can be biomarkers and aid the diagnosis of seizure subtypes.

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Section: Discussionmentioning

confidence: 99%

Deep learning distinguishes focal epilepsy groups using connectomes: Feasibility and clinical implications

Maher

Tang

D’Souza

et al. 2023

Preprint

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“…We also suppressed the right motor thalamic nuclei using chemo- and closed-loop optogenetics and lesioned the corpus callosum. 24 Suppression of the motor thalamus did not prevent bilateral spread, whereas callosal lesioning abolished secondary generalization. Using viral tracing, we found that the right and left thalami have minimal direct monosynaptic commissural connections, whereas the callosum sends extensive contralateral projections that are transmitting seizures.…”

Section: Secondary Bilateral Synchrony During Seizuresmentioning

confidence: 98%

“…31 To disentangle the roles of the thalamus and callosum in bilateral seizure spread, we recorded local field potentials (LFPs) from the bilateral premotor cortex and ventrolateral motor thalamus simultaneously to map their temporal sequence of activation. 24 We selected the motor thalamus because it receives strong projections from the right motor cortex, the seizure focus in our case. 32 Seizures that originated in the right premotor cortex reached the left premotor cortex faster than they did the left thalamus.…”

Section: Secondary Bilateral Synchrony During Seizuresmentioning

confidence: 99%

Connectivity and Excitability Shape Seizure Circuits

Brodovskaya

2022

Epilepsy Curr

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Mapping neuronal circuits that generate focal to bilateral tonic–clonic seizures is essential for understanding general principles of seizure propagation and modifying the risk of death and injury due to bilateral motor seizures. We used novel techniques developed over the past decade to study these circuits. We propose the general hypothesis that at the mesoscale, seizures follow anatomical projections of the seizure focus, preferentially activating more excitable neurons.

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“…In this paper, Brodovskaya and colleagues explore pathways by which focal seizure activity spreads to the opposite hemisphere, causing a GTC. 2 The investigators injected cobalt (Co 2+ ), a proconvulsant divalent cation, into the right frontal cortex of C57Bl/6 mice to create a seizure focus. Seizure activity in the form of epileptic local field potentials (LFPs) was then monitored as it progressed to nearby and distant sites.…”

Section: Commentarymentioning

confidence: 99%