2023
DOI: 10.1161/circulationaha.121.056600
|View full text |Cite
|
Sign up to set email alerts
|

Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support

Abstract: BACKGROUND: Extensive evidence from single-center studies indicates that a subset of patients with chronic advanced heart failure (HF) undergoing left ventricular assist device (LVAD) support show significantly improved heart function and reverse structural remodeling (ie, termed “responders”). Furthermore, we recently published a multicenter prospective study, RESTAGE-HF (Remission from Stage D Heart Failure), demonstrating that LVAD support combined with standard HF medications induced remarkable… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
17
1

Year Published

2023
2023
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 22 publications
(19 citation statements)
references
References 70 publications
1
17
1
Order By: Relevance
“…Despite its promising results, the findings of this study were not recapitulated in a recent study [39]. Luo Echocardiographic findings corroborated these results [40]. Although it is possible that different methods used in these three studies contributed to the different outcomes, this recent controversy highlights the need of more independent investigations to examine whether LVAD implantation and unloading the heart could facilitate endogenous cardiomyocyte proliferation and regeneration.…”
Section: Divergence In Ontogenycontrasting
confidence: 76%
“…Despite its promising results, the findings of this study were not recapitulated in a recent study [39]. Luo Echocardiographic findings corroborated these results [40]. Although it is possible that different methods used in these three studies contributed to the different outcomes, this recent controversy highlights the need of more independent investigations to examine whether LVAD implantation and unloading the heart could facilitate endogenous cardiomyocyte proliferation and regeneration.…”
Section: Divergence In Ontogenycontrasting
confidence: 76%
“…This work showed a marked difference between the differentially expressed transcripts and (phospho)protein profiles as well as downstream signaling pathways, even within the same cohort of patients [90, 154], supporting that multiple layers of regulation coordinate these different biological processes (e.g., transcription, translation, phosphorylation). Moreover, correlation between independent cohorts of proteomics data, as well as proteomic‐transcriptomic data, also suggest minimal overlap in differentially expressed peptides or transcripts, ranging between 4% and 25% overlap [90], which may be attributable to cohort size, sample collection and processing methodologies, as well as the previously described discordance between RNA and protein in human tissue [155]. Interestingly, when compared at the pathway level however, much stronger correlations are evident between individual proteomic datasets [89], suggesting that while individual peptides may not be similarly detected, the overall signaling pathways involved are conserved across different human heart failure cohorts.…”
Section: Multi‐omic Integrationmentioning
confidence: 72%
“…Interestingly, Drakos et al. utilized transcriptomic and (phospho)proteomic profiling to identify subpopulations of heart failure patients with improved outcomes following surgical intervention [90] and a similar multi‐omic approach was used to characterize disease signatures in HCM patient explants [154]. This work showed a marked difference between the differentially expressed transcripts and (phospho)protein profiles as well as downstream signaling pathways, even within the same cohort of patients [90, 154], supporting that multiple layers of regulation coordinate these different biological processes (e.g., transcription, translation, phosphorylation).…”
Section: Multi‐omic Integrationmentioning
confidence: 99%
See 1 more Smart Citation
“…While DCDD may impact on whether to implant LVAD or not, patients and transplant centers need to recognize that many patients with de novo heart failure -however severe in presentation -have not had the opportunity for guideline directed medical therapy or biventricular pacing. These such patients should be strongly considered for durable LVAD as a bridge to recovery, especially as data on new allocation practices indicate that there is a marked decrease in delisting for too well, compared to prior eras, despite increasing translational data on myocardial recovery after myocardial unloading and Guideline Directed Medical Therapy [6,20,21].…”
Section: Changes In Left Ventricular Assist Devices Utilizationmentioning
confidence: 99%