Distinct visual motion processing impairments in aging and Alzheimer’s disease

Kavcic, Voyko; Vaughn, William J.; Duffy, Charles J.

doi:10.1016/j.visres.2010.12.004

Cited by 77 publications

(75 citation statements)

References 62 publications

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“…On the other hand, the de novo appearance of CMs has also been described in nonfamilial disease [104,105,106,107]. Therefore, although external factors have been suggested to be responsible for rapid or sudden changes in the behavior of CMs [108], it is reasonable to argue that genetic alteration remains the main factor influencing the appearance and growth of CMs, both in familial and nonfamilial cases. Genetic aberrations are probably the primary causative factors which, through phenotype modifications, produce altered molecules influencing the angiogenesis network in surrounding tissues [109,110,111].…”

Section: Resultsmentioning

confidence: 99%

Cavernous Malformations of the Central Nervous System in the Pediatric Age Group

et al. 2009

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Objective: The main clinico-diagnostic features, risk factors and associated diseases of cavernous malformations (CMs), also called cavernous angiomas or cavernomas, of the central nervous system (CNS) in children are described, and the most relevant differences compared to the affected adult population are pointed out, focusing on the management of pediatric patients harboring cranial and spinal CMs. Materials: This was a retrospective study of a series of 42 children symptomatic for CMs of the cranial and spinal compartments (35 supratentorial brain lesions, 5 infratentorial and 2 in the spinal region) operated on between 1975 and 2005, with a clinical follow-up ranging from 12 to 192 months. The results were compared with those found in the most recent literature dealing with pediatric CMs of the CNS. Results: Surgical treatment produced excellent or good results in 69% of our 42 children. Unchanged neurological deficits were observed in 23.8% of cases, while morbidity from surgical procedures was 7.14%. Mortality was absent in this series. These surgical results are comparable with those found in the literature, where morbidity and mortality rates from surgery are 8.8 and 1.13%, respectively, and are mostly associated with procedures for the excision of deep, critically located cavernomas. Conclusion: CMs represent the most common CNS vascular lesion in children, although their incidence is 4 times lower than that of the adult population. The natural history of pediatric CMs throughout the neuraxis seems to be more aggressive than in adult patients; these lesions have higher rates of growth and hemorrhage, larger dimensions and often atypical radiological pictures at diagnosis. Beside the familial form of the disease, which is more often associated with multiple lesions and an earlier age of clinical presentation, the major risk factor for CMs in children seems to be radiotherapy for CNS tumors. Furthermore, a greater number of CMs coexistent with mixed angiomatous lesions have been reported in children than in adults. Surgical results are related to the preoperative neurological status of the children; symptomatic patients who are operated on early, before they develop severe neurological deficits or long-standing seizures, may achieve the best clinical outcome. Radiosurgery does not seem to be advisable in children as an alternative treatment for deep CMs or those causing epilepsy.

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Section: Resultsmentioning

confidence: 99%

Cavernous Malformations of the Central Nervous System in the Pediatric Age Group

et al. 2009

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“…It has been shown that even young adults when provided with a bar in front when standing up, generated much higher horizontal momentum than when standing up with an empty space in front (Pai & Lee, 1994). It is also possible that presence of the table provided a visual reference point and compensated for spatial orientation and motion processing problems (Kavcic, Vaughn, & Duffy, 2011), decreased depth and contrast perception (Valenti, 2010), and balance problems, common in people living with dementia (Suttanon et al, 2012;Taylor, Delbaere, Lord, Mikolaizak, & Close, 2013).…”

Section: Variablesmentioning

confidence: 99%

Comparison of sit-to-stand strategies used by older adults and people living with dementia

Dolecka

Ownsworth

Kuys

2015

Archives of Gerontology and Geriatrics

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“…The addition of a secondary task tends to decrease task performance more strongly in older adults than in younger adults (Bisson et al, 2014;de Dieuleveult et al, 2017;Mahboobin et al, 2007;Redfern et al, 2001Redfern et al, , 2009. It is well known that the age-related deterioration of, for instance, vision (Kavcic et al, 2011;Owsley, 2011), joint mobility (Yeh et al, 2015), muscle force (Cruz-Jentoft et al, 2010), and balance (Teasdale et al, 1991) all decrease performance of the activities of daily living. How changes in sensory integration influence age-related decline in activities of daily living is less well researched.…”

Section: Introductionmentioning

confidence: 99%

“…Vision guides goal-directed reach movements towards moving targets (Brenner and Smeets, 2015;Brouwer et al, 2002Brouwer et al, , 2003Kavcic et al, 2011). When judging the target's motion, one could simply rely on the target's retinal slip together with extra-retinal information about eye, head and body movements, but one might be able to improve the precision by assuming that the environment is stable.…”

Section: Introductionmentioning

confidence: 99%

Aging and Sensitivity to Illusory Target Motion With or Without Secondary Tasks

Dieuleveult

Brouwer²,

Siemonsma

et al. 2018

Multisens Res

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Older individuals seem to find it more difficult to ignore inaccurate sensory cues than younger individuals. We examined whether this could be quantified using an interception task. Twenty healthy young adults (age 18-34) and twenty-four healthy older adults (age 60-82) were asked to tap on discs that were moving downwards on a screen with their finger. Moving the background to the left made the discs appear to move more to the right. Moving the background to the right made them appear to move more to the left. The discs disappeared before the finger reached the screen, so participants had to anticipate how the target would continue to move. We examined how misjudging the disc's motion when the background moves influenced tapping. Participants received veridical feedback about their performance, so their sensitivity to the illusory motion indicates to what extent they could ignore the task-irrelevant visual information. We expected older adults to be more sensitive to the illusion than younger adults. To investigate whether sensorimotor or cognitive load would increase this sensitivity, we also asked participants to do the task while standing on foam or counting tones. Background motion influenced older adults more than younger adults. The secondary tasks did not increase the background's influence. Older adults might be more sensitive to the moving background because they find it more difficult to ignore irrelevant sensory information in general, but they may rely more on vision because they have less reliable proprioceptive and vestibular information.

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Distinct visual motion processing impairments in aging and Alzheimer’s disease

Cited by 77 publications

References 62 publications

Cavernous Malformations of the Central Nervous System in the Pediatric Age Group

Cavernous Malformations of the Central Nervous System in the Pediatric Age Group

Comparison of sit-to-stand strategies used by older adults and people living with dementia

Aging and Sensitivity to Illusory Target Motion With or Without Secondary Tasks

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