Distinction of differentiated type early gastric carcinoma with gastric type mucin expression

Koseki, Keita; Takizawa, Touichiro; Koike, Morio; Ito, Masashi; Nihei, Zenro; Sugihara, Kenichi

doi:10.1002/1097-0142(20000815)89:4<724::aid-cncr2>3.3.co;2-w

Cited by 46 publications

(68 citation statements)

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“…However, recent mucin histochemical and immunohistochemical examinations have demonstrated that gastric and intestinal phenotypic cell markers are widely expressed in gastric carcinomas, irrespective of their histologic type (Tatematsu et al, 1990;Egashira et al, 1999;Endoh et al, 1999Endoh et al, , 2000Koseki et al, 2000;Saito et al, 2001;Tajima et al, 2001aTajima et al, , b, 2003Tsukashita et al, 2001;Kabashima et al, 2002;Shibata et al, 2003). Several authors have reported that gastric carcinomas can be classified as having either a gastric (G), gastric and intestinal mixed (GI) or intestinal (I) phenotype, depending on the immunopositivity of human gastric mucin (HGM), MUC6, MUC2 and CD10 stainings (Tajima et al, 2001b(Tajima et al, , 2003Kabashima et al, 2002).…”

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confidence: 99%

“…Thus, the previous data described above suggest that gastric carcinomas can occur in various types of gastric mucosa, although differentiated tumours have generally been considered to arise from gastric mucosa with intestinal metaplasia and undifferentiated tumours to arise from ordinary gastric mucosa without intestinal metaplasia (Lauren, 1965;Nakamura et al, 1968). Recently, G-phenotype tumours have been associated with poorer outcome and greater malignant potential in the incipient phase of invasion and metastasis, compared with those of other phenotype tumours (Endoh et al, 1999;Koseki et al, 2000;Saito et al, 2001;Tajima et al, 2001b;Kabashima et al, 2002;Shibata et al, 2003). Therefore, phenotypic classification could be useful not only for investigating the tumorigenesis of gastric carcinoma, but also for evaluating tumour aggressiveness.…”

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Gastric and intestinal phenotypic marker expression in gastric carcinomas and recurrence pattern after surgery-immunohistochemical analysis of 213 lesions-

et al. 2004

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Both gastric and intestinal phenotypic markers are known to be expressed in gastric carcinomas, irrespective of their histologic type. In the present study, the relation between gastric and intestinal phenotypic marker expression in gastric carcinomas and the recurrence pattern after surgery was examined. The phenotypic marker expression of the tumour was determined by examining the expression of human gastric mucin (HGM), MUC6, MUC2 and CD10 in 213 advanced gastric carcinomas in 213 patients who had undergone a curative resection (97 died from recurrent gastric carcinoma and 116 were alive without recurrence at the end of the follow-up period). Tumours were classified into gastric (G), gastric and intestinal mixed (GI), intestinal (I) or unclassified (UC) phenotypes according to the immunopositivity of HGM, MUC6, MUC2 and CD10 stainings. The incidence of HGM-positive tumours and MUC2-negative tumours was significantly higher in tumours with peritoneal recurrence than in tumours without recurrence (73.3%, 44 out of 60 cases vs 54.3%, 63 out of 116 (P ¼ 0.022); and 70.0%, 42 out of 60 vs 38.8%, 45 out of 116 (P ¼ 0.0002), respectively). The incidence of G-phenotype tumours was also significantly higher in tumours with peritoneal recurrence than in tumours without recurrence (58.3%, 35 out of 60 cases vs 28.4%, 33 out of 116 (P ¼ 0.0002)). The incidence of MUC2-negative tumours and CD10-positive tumours was significantly higher in tumours with haematogenous recurrence than in tumours without recurrence (62.5%, 20 out of 32 cases vs 38.8%, 45 out of 116 (P ¼ 0.028); and 43.8%, 14 out of 32 vs 23.3%, 27 out of 116 (P ¼ 0.039); respectively). Our present findings show that the gastric and intestinal phenotypic marker expression of the tumour, determined by immunohistochemical staining for HGM, MUC6, MUC2 and CD10, can be used to predict the pattern of gastric carcinoma recurrence after curative resection.

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Gastric and intestinal phenotypic marker expression in gastric carcinomas and recurrence pattern after surgery-immunohistochemical analysis of 213 lesions-

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“…The reason for selecting the same macroscopic type was that it has been reported that the protruded type and superficial elevated type are common among papillary adenocarcinomas. Koseki et al [9] reported that compared to tubular adenocarcinomas, papillary adenocarcinomas have more type 0-I (protruded type) and type 0-IIa (superficial elevated type), and less depressed type.…”

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confidence: 99%

“…Basically, it is categorized as a structural subtype of differentiated cancer, together with tubular adenocarcinoma. Various histological studies have reported that papillary adenocarcinoma shows a higher degree of malignancy than tubular adenocarcinoma [2][3][4][5][6][7][8][9].…”

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The vessels within epithelial circle (VEC) pattern as visualized by magnifying endoscopy with narrow-band imaging (ME-NBI) is a useful marker for the diagnosis of papillary adenocarcinoma: a case-controlled study

et al. 2013

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Background and aims Pathological studies indicate papillary adenocarcinomas are more aggressive than tubular adenocarcinomas, but a definitive diagnosis is difficult using conventional endoscopy alone. The vessels within an epithelial circle (VEC) pattern, visualized using magnifying endoscopy with narrow-band imaging (ME-NBI), may be a feature of papillary adenocarcinoma. The aims of our study were to investigate whether the VEC pattern is useful in the preoperative diagnosis of papillary adenocarcinoma and to determine whether VEC-positive adenocarcinomas are more malignant than VEC-negative lesions. Patients and materials From 395 consecutive early gastric cancers resected using the endoscopic submucosal dissection method, we analyzed 35 VEC-positive lesions and 70 VEC-negative control lesions matched for size and macroscopic type. We evaluated (1) the correlation between the incidence of VEC-positive cancers and the histological papillary structure and (2) differences in the incidence of coexisting undifferentiated carcinoma in VEC-positive and VEC-negative cancers and the incidence of submucosal and vascular invasion.Results Histological papillary structure was seen in 94 % (33/35) of VEC-positive and 9 % (6/70) of VEC-negative cancers, a significant difference (P \ 0.001). The incidence of coexisting undifferentiated carcinoma was 23 % (8/35) in VEC-positive and 3 % (2/70) in VEC-negative cancers (P = 0.002). The incidence of submucosal invasion by the carcinoma was 26 % (9/35) in VEC-positive cancers and 10 % (7/70) in VEC-negative cancers (P = 0.045). Conclusions The VEC pattern as visualized using ME-NBI is a promising preoperative diagnostic marker of papillary adenocarcinoma. Coexisting undifferentiated carcinoma and submucosal invasion were each seen in approximately one fourth of VEC-positive cancers.

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Combined evaluation of mucin antigen and E-cadherin expression may help select patients with gastric cancer suitable for minimally invasive therapy

Tanaka

Kitajima

Sato

et al. 2003

British Journal of Surgery

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Background: MUC1 mucin is known to be highly expressed in carcinomas that show invasive growth and poor prognosis. Impairment of adhesion molecule E-cadherin expression has been widely accepted as a critical event for cancer invasion and metastasis. The present study evaluated the combination of mucin and E-cadherin status as a possible predictor of patients suitable for minimally invasive therapy for gastric cancer.Methods: Two hundred and nine paraffin-embedded specimens of gastric carcinoma (141 early, 68 advanced) were examined by immunohistochemical staining using monoclonal antibodies against MUC1 mucin (MUC-1-CORE, DF3), MUC2 mucin (Ccp58) and E-cadherin (anti-E-cad).Results: Gastric carcinoma with MUC1-positive expression demonstrated malignant characteristics. Normal E-cadherin expression showed an inverse correlation with MUC1 expression. Patients with early gastric carcinoma who had a combination of normal E-cadherin and MUC1-negative expression had no recurrence and a favourable prognosis. Moreover, cancers with normal E-cadherin/MUC1-negative expression were not found at an advanced stage in differentiated-type carcinoma. Conclusion: A normal E-cadherin/MUC1-negative expression pattern in gastric cancer is a favourable marker. Preoperative estimation of the E-cadherin and MUC1 status of an endoscopic biopsy specimen may help select appropriate patients for minimally invasive treatment of gastric cancer.

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Distinction of differentiated type early gastric carcinoma with gastric type mucin expression

Cited by 46 publications

References 4 publications

Gastric and intestinal phenotypic marker expression in gastric carcinomas and recurrence pattern after surgery-immunohistochemical analysis of 213 lesions-

Gastric and intestinal phenotypic marker expression in gastric carcinomas and recurrence pattern after surgery-immunohistochemical analysis of 213 lesions-

The vessels within epithelial circle (VEC) pattern as visualized by magnifying endoscopy with narrow-band imaging (ME-NBI) is a useful marker for the diagnosis of papillary adenocarcinoma: a case-controlled study

Combined evaluation of mucin antigen and E-cadherin expression may help select patients with gastric cancer suitable for minimally invasive therapy

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