Distinctive eosinophilic cytoplasmic inclusion bodies in melanocytic nevi: an immunohistochemical and ultrastructural study

Abstract

The inclusion bodies described herein bear no resemblance to other cytoplasmic inclusion bodies previously described in melanocytic lesions. There is no discernible relationship to melanosomes by ultrastructural analysis. We postulate a relationship with dysfunction of ubiquitin-mediated protein degradation occurring in melanocytes.

Rosette‐like structures in the spectrum of spitzoid tumors

“…While we regard the nuclear palisading and central fibrillary cytoplasm seen in rosette-like structures to be quite distinctive, we cannot exclude the possibility they represent a morphologic variant of multinucleated giant nevus cells at least in a subset of cases. Furthermore, we did not observe eosinophilic cytoplasmic inclusion bodies, which can be seen in multinucleated spitzoid melanocytes as recently described by Shon et al 37 In summary, we report rosette-like structures in three spitzoid lesions from a retrospective review of 104 cases spanning the spectrum of spitzoid lesions. Although uncommon, rosette-like structures may occur as a focal finding in Spitz nevi and atypical Spitz tumors.…”