Distinctive modulation of inflammatory and metabolic parameters in relation to zinc nutritional status in adult overweight/obese subjects

Costarelli, Laura; Muti, Elisa; Malavolta, Marco; Cipriano, Catia; Giacconi, Robertina; Tesei, Silvia; Piacenza, Francesco; Pierpaoli, Sara; Gasparini, Nazzarena; Faloia, Emanuela; Tirabassi, Giacomo; Boscaro, Marco; Polito, Angela; Mauro, Béatrice; Maiani, Francesca; Raguzzini, Anna; Marcellini, Francesca; Giuli, Cinzia; Papa, Roberta; Emanuelli, Monica; Lattanzio, Fabrizia; Mocchegiani, Eugenio

doi:10.1016/j.jnutbio.2009.02.001

Cited by 79 publications

(67 citation statements)

References 58 publications

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“…Epidemiological studies have observed that hyperzincuria and hypozincemia are commonly seen in T2D although the mechanism for the urinary loss has not been fully identified [4,5]. Costarelli et al [28] found that subjects with a lower dietary zinc intake display general impairment of their zinc status, an altered lipid profile and increased insulin production in comparison to obese subjects with normal zinc dietary intake. As mentioned above few studies have examined the effect of zinc supplementation in T2D patients with some showing an improvement in glycaemic control.…”

Section: Discussionmentioning

confidence: 99%

Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women’s health

et al. 2013

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BackgroundAnimal studies have shown that zinc intake has protective effects against type 2 diabetes, but few studies have been conducted to examine this relationship in humans. The aim of this study is to investigate if dietary zinc is associated with risk of type 2 diabetes in a longitudinal study of mid-age Australian women.MethodsData were collected from a cohort of women aged 45-50 years at baseline, participating in the Australian Longitudinal Study on Women’s Health. A validated food frequency questionnaire was used to assess dietary intake and other nutrients. Predictors of 6-year incidence of type 2 diabetes were examined using multivariable logistic regression.ResultsFrom 8921 participants, 333 incident cases of type 2 diabetes were identified over 6 years of follow-up. After adjustment for dietary and non-dietary factors, the highest quintile dietary zinc intake had almost half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I. 0.32–0.77) compared with the lowest quintile. Similar findings were observed for the zinc/iron ratio; the highest quintile had half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I 0.30-0.83) after multivariable adjustment of covariates.ConclusionsHigher total dietary zinc intake and high zinc/iron ratio are associated with lower risk of type 2 diabetes in women. This finding is a positive step towards further research to determine if zinc supplementation may reduce the risk of developing type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women’s health

et al. 2013

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“…Some conditions are associated with chronic inflammation such as obesity, where patients with lower zinc dietary intake present with lower plasma and intracellular zinc concentrations along with upregulated gene expression of IL-1α, IL-1β, and IL-6 compared to patients with higher zinc intake [73]. …”

Section: Zinc In Inflammationmentioning

confidence: 99%

Zinc in Infection and Inflammation

2017

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Micronutrient homeostasis is a key factor in maintaining a healthy immune system. Zinc is an essential micronutrient that is involved in the regulation of the innate and adaptive immune responses. The main cause of zinc deficiency is malnutrition. Zinc deficiency leads to cell-mediated immune dysfunctions among other manifestations. Consequently, such dysfunctions lead to a worse outcome in the response towards bacterial infection and sepsis. For instance, zinc is an essential component of the pathogen-eliminating signal transduction pathways leading to neutrophil extracellular traps (NET) formation, as well as inducing cell-mediated immunity over humoral immunity by regulating specific factors of differentiation. Additionally, zinc deficiency plays a role in inflammation, mainly elevating inflammatory response as well as damage to host tissue. Zinc is involved in the modulation of the proinflammatory response by targeting Nuclear Factor Kappa B (NF-κB), a transcription factor that is the master regulator of proinflammatory responses. It is also involved in controlling oxidative stress and regulating inflammatory cytokines. Zinc plays an intricate function during an immune response and its homeostasis is critical for sustaining proper immune function. This review will summarize the latest findings concerning the role of this micronutrient during the course of infections and inflammatory response and how the immune system modulates zinc depending on different stimuli.

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“…Some conditions that are associated with chronic inflammation such as obesity, where patients with lower zinc dietary intake present with lower plasma and intracellular zinc concentrations along with upregulated gene expression of IL-1α, IL-1β, and IL-6 compared to patients with higher zinc intake [68].…”

Section: Zinc Status and Inflammatory Cytokinesmentioning

confidence: 99%

Zinc in Infection and Inflammation

Gammoh¹,

Rink²

2017

Preprint

187

139

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Abstract:Micronutrient homeostasis is a key factor in maintaining a healthy immune system. Zinc is an essential micronutrient that is involved in the regulation of the innate and adaptive immune responses. The main cause of zinc deficiency is malnutrition. Zinc deficiency leads to cell-mediated immune dysfunctions among other manifestations. Consequently, such dysfunctions lead to a worse outcome in the response towards bacterial infection and sepsis. For instance, zinc is an essential component of the pathogen-eliminating signal transduction pathways leading to neutrophil extracellular traps formation, as well as inducing cell-mediated immunity over humoral immunity by regulating specific factors or differentiation. Additionally, zinc deficiency plays a role in inflammation, mainly elevating inflammatory response as well as damage to host tissue. Zinc is involved in the modulation of the proinflammatory response by targeting Nuclear Factor Kappa B, a transcription factor that is the master regulator of proinflammatory responses. It is also involved in controlling oxidative stress and regulating inflammatory cytokines. Zinc plays an intricate function during an immune response and its homeostasis is critical for sustaining proper immune function. This review will summarize the latest findings concerning the role of this micronutrient during the course of infections and inflammatory response and how the immune system modulates zinc depending on different stimuli.

show abstract

Distinctive modulation of inflammatory and metabolic parameters in relation to zinc nutritional status in adult overweight/obese subjects

Cited by 79 publications

References 58 publications

Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women’s health

Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women’s health

Zinc in Infection and Inflammation

Zinc in Infection and Inflammation

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