Distinguishing benign from malignant liver tumours

Heiken, Jay P.

doi:10.1102/1470-7330.2007.9084

Cited by 53 publications

(33 citation statements)

References 125 publications

(121 reference statements)

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“…It can be challenging to distinguish between benign and malignant liver disease and to identify and differentiate lesions in the setting of a steatotic ("fatty") or cirrhotic liver 24,25 . Heiken et al 26 reported that 10%-20% of solid benign tumours may display atypical features that could be confused with hepatocellular carcinoma, cholangiocarcinoma, or hypervascular metastases. In addition, hepatocellular adenoma can often have a varied appearance, and certain subtypes such as infiltrative hepatocellular carcinoma can frequently be missed completely by inexperienced radiologists 27,28 .…”

Section: (E)mentioning

confidence: 99%

Impact of a Single-Day Multidisciplinary Clinic on the Management of Patients with Liver Tumours

et al. 2013

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51%) returned for a follow-up, and 154 of the returnees (89%) received treatment, primarily intraarterial therapy (n = 88, 57%), systemic chemotherapy (n = 60, 39%), or liver resection (n = 32, 21%). Enrollment in a clinical trial was proposed to 34 patients (10%), and 21 of the 34 (62%) were accrued. ConclusionsPatient assessment by our multidisciplinary liver clinic had a significant impact on management, resulting in alterations to imaging and pathology interpretation, diagnosis, and management plan. The mdlc is an effective and convenient means of delivering expert opinion about the diagnosis and management of liver tumours.

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Section: (E)mentioning

confidence: 99%

Impact of a Single-Day Multidisciplinary Clinic on the Management of Patients with Liver Tumours

et al. 2013

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“…This technique has the advantage of being fast and sensitive when gas is present inside the bowels, and it can give a good representation of all abdominal organs (14). Modern CT equipment combined with a contrast medium provides a reliable imaging method with high spatial resolution in several phases of vessel enhancement enabling imaging of the liver in 1-2 arterial phases, the portal venous phase and later phases if needed to distinguish benign from malignant liver lesions (20,38). The kidneys are easy to examine, identify and define with a CT examination.…”

Section: Ultrasound and Other Modalities For Imaging The Kidneys And mentioning

confidence: 99%

“…Contrast-enhanced ultrasonography (CEUS) has improved both the detection and characterization of focal liver lesions and has been shown to be an important imaging method, and plays a major role in distinguishing benign from malignant liver lesions (15)(16)(17)(18)(19)(20). CEUS can be performed for a variety of indications on practically all parts of the human body (21,22).…”

Section: Introductionmentioning

confidence: 99%

Standardized ultrasonography with cine-loop documentation : diagnostic variability in liver and kidney examinations

Stenman¹

2016

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“…LCA specimens are soft and light brown to yellow. 10,17 Spontaneous hemorrhage is possible because of the high-pressure blood supply and bloodfilled sinusoids combined with poor soft tissue support. 3 A study of MRI features and pathology of 20 LA patients found three types of LA cell types: steatotic, peliotic, and mixed.…”

mentioning

confidence: 99%

“…In a study of 15 patients with LA, three had a vascular malformation involving the portal vein that was congenitally absent or thrombosed or had portosytemic venous shunts. 14,17 Along with two theories as to the cause of LA, there are also two types. Multifocal LA tends to be more common in asymptomatic patients.…”

mentioning

confidence: 99%

Incidental Findings: A Case Study of Benign Liver Masses

Boodt

2011

Journal of Diagnostic Medical Sonography

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With increased medical imaging, the discovery of incidental solid liver lesions ("incidentalomas") has risen. 1 Sonographers routinely discover hepatic hemangiomas when performing abdominal studies. Their characteristic echogenic, homogeneous, well-circumscribed appearance is well known and no cause for alarm. About 4% of the population has hemangiomas.2 Second in frequency are focal nodular hyperplasias (FNHs). FNH is not a true neoplasm but an overgrowth of hepatocytes in response to an abnormal blood supply. FNH appears sonographically isoechoic to the liver parenchyma and is identified by a bulged contour or an increased blood supply. Hemangiomas and FNH present no danger to the patient; therefore, further testing and monitoring are not necessary once a diagnosis has been made. The third type of "incidentalomas," liver cell adenomas (LCAs), are rare and pose a health risk because they tend to hemorrhage and may evolve into hepatocellular carcinoma. For this reason, they require treatment by liver resection or monitoring. Liver adenomatosis (LA) is a condition in which multiple LCAs are present in the liver. LA occurs in 10% to 24% of patients with LCA and is classified as a separate disorder because of a differing etiology.3 This article summarizes a rare case with multiple liver hemangiomas, FNHs, and LCAs followed by a discussion of these benign liver lesions and LA. Case StudyAn asymptomatic woman in her mid-50s had an incidental finding of innumerable solid liver tumors by sonography. Her history was significant for alloimmune thrombocytopenia onset during adolescence, splenectomy, previous limited use of oral contraceptives, hysterectomy, and bilateral oophorectomy with subsequent use of estrogen hormone replacement for a number of years and long-term use of serotonin uptake inhibitors. Her mother died in her mid-50s from cholangiocarcinoma.A right upper quadrant sonogram, abdominal computed tomography (CT) scan, liver magnetic resonance imaging (MRI) scan, CT-guided percutaneous liver biopsy of the two most inferior right lobe lesions, and laboratory tests were performed to diagnose the liver lesions.Sonography showed a well-defined 2-cm echogenic nodule characteristic of a hemangioma in the right lobe. In the most inferior aspect of the right lobe, two coalescing isoechoic nodules were identified because they distorted the usual contour. Other echogenic nodules were also noted. CT identified the hemangioma and differentiated between the two inferior FNHs (2 and 3 cm) and multiple LCAs. The two largest LCAs were 3.2 and 3.5 cm. The CT report could not exclude malignancy. A dynamic MRI was performed. Two hemangiomas, two FNHs, and innumerable LCAs were identified by MRI. The largest two LCAs measured 3.3 cm. They appeared to contain foci on intracellular lipids and showed increased flow in the arterial phase. The two inferior right

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Distinguishing benign from malignant liver tumours

Cited by 53 publications

References 125 publications

Impact of a Single-Day Multidisciplinary Clinic on the Management of Patients with Liver Tumours

Impact of a Single-Day Multidisciplinary Clinic on the Management of Patients with Liver Tumours

Standardized ultrasonography with cine-loop documentation : diagnostic variability in liver and kidney examinations

Incidental Findings: A Case Study of Benign Liver Masses

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