Distinguishing between the complications of Wilson disease-related cirrhosis and HBV-related cirrhosis

Zhong, Hao‐Jie; Zhuang, Yu-Pei; Zhang, Yi-Ting; Xu, Shun-Peng; Hong, Ming‐Fan; He, Xiaofu

doi:10.1080/03007995.2021.1993160

Cited by 2 publications

(1 citation statement)

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“…Several clinical indicators are widely used nowadays to evaluate the severity of chronic liver diseases and predict their progression [8][9][10]. However, because patients with WD have significantly different liver features and complications compared to patients with other liver diseases [11,12], it remains unclear whether these indicators could be used to assess the severity, complications, and progression of WD.…”

Section: Introductionmentioning

confidence: 99%

Anemia Is Associated with Disease Severity, Hepatic Complications, and Progression of Wilson Disease: A Retrospective Cohort Study

Wang

Zhan

Huang

et al. 2023

Dig Dis

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Introduction: Anemia is a common manifestation of chronic liver diseases. It is a predictor of severe disease, a high risk of complications, and poor outcomes in various liver diseases. However, it remains unclear whether anemia serves as a similar indicator in patients with Wilson disease (WD). Therefore, this study aimed to investigate the relationship between anemia and severity, hepatic complications, and the progression of WD. Methods: Medical data were collected retrospectively from January 1, 2016, to December 31, 2020. Univariate and multivariate analyses were carried out to investigate the relationship between anemia and liver-associated disease severity, hepatic complications, and the progression of WD. Results: A total of 288 WD patients (48 with and 240 without anemia) were enrolled in the study. Multivariate linear regression revealed that WD patients with anemia had significantly higher levels of bilirubin, alanine transaminase, prothrombin time, international normalized ratio, type Ⅳ collagen, and hyaluronic acid and significantly lower levels of albumin, total cholesterol, and high-density lipoprotein-cholesterol (all P < 0.05). Multivariate logistic regression showed that anemia was a risk factor for gastric varices and ascites (all P < 0.05). Fully adjusted Cox regression revealed that anemia was an independent risk factor for advanced Child–Pugh classification (P = 0.034). Conclusions: Anemia was common in WD patients and was associated with greater disease severity, a higher risk of hepatic complications, and a faster progression.

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Section: Introductionmentioning

confidence: 99%

Anemia Is Associated with Disease Severity, Hepatic Complications, and Progression of Wilson Disease: A Retrospective Cohort Study

Wang

Zhan

Huang

et al. 2023

Dig Dis

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Exploring the impact of gut microbiota on liver health in mice and patients with Wilson disease

Zhong,

Liu,

Huang

et al. 2024

Liver International

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Background and AimsDistinctive gut microbial profiles have been observed between patients with Wilson disease (WD) and healthy individuals. Despite this, the exact relationship and influence of gut microbiota on the advancement of WD‐related liver damage remain ambiguous. This research seeks to clarify the gut microbiota characteristics in both human patients and mouse models of WD, as well as their impact on liver injury.MethodsGut microbial features in healthy individuals, patients with WD, healthy mice and mice with early‐ and late‐stage WD were analysed using 16S rRNA gene sequencing. Additionally, WD‐afflicted mice underwent treatment with either an antibiotic cocktail (with normal saline as a control) or healthy microbiota (using disease microbiota as a control). The study assessed gut microbiota composition, hepatic transcriptome profiles, liver copper concentrations and hepatic pathological injuries.ResultsPatients with hepatic WD and mice with WD‐related liver injury displayed altered gut microbiota composition, notably with a significant reduction in Lactobacillus abundance. Additionally, the abundances of several gut genera, including Lactobacillus, Veillonella and Eubacterium coprostanoligenes, showed significant correlations with the severity of liver injury in patients with WD. In WD mice, antibiotic treatment or transplantation of healthy microbiota altered the gut microbial structure, increased Lactobacillus abundance and modified the hepatic transcriptional profile. These interventions resulted in reduced hepatic copper concentration and alleviation of WD‐related liver injury.ConclusionsIndividuals and mice with pronounced WD‐related liver injury exhibited shifts in gut microbial composition. Regulating gut microbiota through healthy microbiota transplantation emerges as a promising therapeutic approach for treating WD‐related liver injury.

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Distinguishing between the complications of Wilson disease-related cirrhosis and HBV-related cirrhosis

Cited by 2 publications

References 40 publications

Anemia Is Associated with Disease Severity, Hepatic Complications, and Progression of Wilson Disease: A Retrospective Cohort Study

Anemia Is Associated with Disease Severity, Hepatic Complications, and Progression of Wilson Disease: A Retrospective Cohort Study

Exploring the impact of gut microbiota on liver health in mice and patients with Wilson disease

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