Distortion of frontal bones results from cell apoptosis by the mechanical force from the up-migrating eye during metamorphosis in Paralichthys olivaceus

Sun, Meng; Fang, Wei; Li, Hui; Xu, Juan; Chen, Xinye; Gong, Xiaoling; Tian, Yongsheng; Chen, Songlin; Bao, Baolong

doi:10.1016/j.mod.2015.01.001

Cited by 21 publications

(6 citation statements)

References 46 publications

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“…During flatfish metamorphosis, a pelagic and bilateral symmetric larva becomes a benthonic asymmetric juvenile. Profound internal and external changes, such as eye migration to the opposite side of the body, remodelling of the craniofacial complex [ 11 , 12 , 13 ] and redistribution of the skin pigmentation [ 14 ], lead to an asymmetric juvenile fish adapted to benthic life.…”

Section: Introductionmentioning

confidence: 99%

Brains in Metamorphosis: Temporal Transcriptome Dynamics in Hatchery-Reared Flatfishes

Guerrero-Peña

Suárez-Bregua

Méndez-Martínez

et al. 2021

Biology

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Metamorphosis is a captivating process of change during which the morphology of the larva is completely reshaped to face the new challenges of adult life. In the case of fish, this process initiated in the brain has traditionally been considered to be a critical rearing point and despite the pioneering molecular work carried out in other flatfishes, the underlying molecular basis is still relatively poorly characterized. Turbot brain transcriptome of three developmental stages (pre-metamorphic, climax of metamorphosis and post-metamorphic) were analyzed to study the gene expression dynamics throughout the metamorphic process. A total of 1570 genes were differentially expressed in the three developmental stages and we found a specific pattern of gene expression at each stage. Unexpectedly, at the climax stage of metamorphosis, we found highly expressed genes related to the immune response, while the biological pathway enrichment analysis in pre-metamorphic and post-metamorphic were related to cell differentiation and oxygen carrier activity, respectively. In addition, our results confirm the importance of thyroid stimulating hormone, increasing its expression during metamorphosis. Based on our findings, we assume that immune system activation during the climax of metamorphosis stage could be related to processes of larval tissue inflammation, resorption and replacement, as occurs in other vertebrates.

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Section: Introductionmentioning

confidence: 99%

Brains in Metamorphosis: Temporal Transcriptome Dynamics in Hatchery-Reared Flatfishes

Guerrero-Peña

Suárez-Bregua

Méndez-Martínez

et al. 2021

Biology

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“…Indeed, the mechanical forces at play are thought to be important for the occurrence and evolution of the skeleton ( Danos and Ward, 2012 ). External mechanical forces can regulate genetic pathways of both cartilage and bone development ( Andreassen et al, 2001 ; Fan et al, 2006 ; Haasper et al, 2008 ; Robling et al, 2008 ; Wu et al, 2001 ; Sun et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Different ossification patterns of intermuscular bones in fish with different swimming modes

Yao

Gong

et al. 2015

Biology Open

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Intermuscular bones are found in the myosepta in teleosts. However, there is very little information on the development and ossification of these intermuscular bones. In this study, we performed an in-depth investigation of the ossification process during development in zebrafish (Danio rerio) and Japanese eel (Anguilla japonica). In Japanese eel, a typical anguilliform swimmer, the intermuscular bones ossified predominantly from the anterior to the posterior. By contrast, in the zebrafish, a sub-carangiform or carangiform swimmer, the intermuscular bones ossified predominantly from the posterior to the anterior regions of the fish. Furthermore, tail amputation affected the ossification of the intermuscular bones. The length of the intermuscular bones in the posterior area became significantly shorter in tail-amputated zebrafish and Japanese eels, and both had less active and lower swimming speeds; this indicates that swimming might induce the ossification of the intermuscular bones. Moreover, when a greater length of tail was amputated in the zebrafish, the intermuscular bones became even shorter. Tail amputation affected the length and ossification of intermuscular bones in the anterior part of the fish, close to the head, differently between the two fish: they became significantly shorter in the zebrafish, but did not in the Japanese eel. This might be because tail amputation did not significantly affect the undulations in the anterior of the Japanese eel, especially near the head. This study shows that the ossification of intermuscular bones might be induced through mechanical force loadings that are produced by swimming.

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“…An organism that has to cope with two completely different lifestyles must undergo many morphological, physiological and behavioral changes in a very short period of time 1 . Flatfish undergo one of the most dramatic metamorphoses known in teleosts, in which a symmetrical pelagic larva becomes an asymmetric benthic juvenile 2 , facing internal and external changes such as remodeling of the craniofacial complex 3 , eye migration 4,5 or redistribution of the skin pigmentation 6 . Although flatfish metamorphosis is well described and the central role of thyroid hormone is well established [7][8][9] , few data are available on the regulation of possible specific target genes in the context of the gene network responsible for metamorphic remodeling of larval tissues.…”

Section: Background and Summarymentioning

confidence: 99%

Genome-wide chromatin accessibility and gene expression profiling during flatfish metamorphosis

et al. 2023

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Metamorphosis is a widely studied post-embryonic process in which many tissues undergo dramatic modifications to adapt to the new adult lifestyle. Flatfishes represent a good example of metamorphosis in teleost fishes. During metamorphosis of flatfish, organ regression and neoformation occur, with one of the most notable changes being the migration of one of the eyes to the other side of the body. In order to create a useful and reliable tool to advance the molecular study of metamorphosis in flatfish, we generated a chromatin accessible atlas as well as gene expression profile during four developmental stages ranging from a phylotypic to a post-metamorphic stage. We identified 29,019 differentially accessible chromatin regions and 3,253 differentially expressed genes. We found stage-specific regulatory regions and gene expression profiles, supporting the quality of the results. Our work provides strongly reproducible data for further studies to elucidate the regulatory elements that ensure successful metamorphosis in flatfish species.

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Distortion of frontal bones results from cell apoptosis by the mechanical force from the up-migrating eye during metamorphosis in Paralichthys olivaceus

Cited by 21 publications

References 46 publications

Brains in Metamorphosis: Temporal Transcriptome Dynamics in Hatchery-Reared Flatfishes

Brains in Metamorphosis: Temporal Transcriptome Dynamics in Hatchery-Reared Flatfishes

Different ossification patterns of intermuscular bones in fish with different swimming modes

Genome-wide chromatin accessibility and gene expression profiling during flatfish metamorphosis

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