Distortion of time interval reproduction in an epileptic patient with a focal lesion in the right anterior insular/inferior frontal cortices

Monfort, Vincent; Pfeuty, Micha; Klein, Madelyne; Collé, Steffie; Brissart, Hélène; Jonas, Jacques; Maillard, Louis

doi:10.1016/j.neuropsychologia.2014.09.004

Cited by 13 publications

(10 citation statements)

References 68 publications

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“…The observed emotional effect was consistent with what is classically reported in the literature: Emotional sounds appeared to last longer than neutral sounds (Droit‐Volet & Meck, ; Mella et al, ; Noulhiane et al, ; Tipples, ). Our result is also consistent with the single‐case study of Monfort et al (), showing that a focal lesion in the right anterior insula in a single patient did not lead to over‐reproduction of emotional durations. However, unlike in our study, the authors report in this patient a global overestimation of durations, being with neutral or emotional stimuli.…”

Section: Discussionsupporting

confidence: 93%

“…Griffiths et al () reported a deficit in analyzing temporal sequences of sounds in a patient with a bilateral lesion of the insula. More recently, using a time reproduction task with negative and neutral pictures, Monfort et al () showed that a focal lesion of the right anterior insula was associated to aberrant reproduction times, suggesting that this structure would be involved in temporal precision independently of the nature of the stimulus. Lastly, a voxel based symptom‐lesion mapping study showed that lesions in the white matter posterior to the insula as well as in the insula were related to larger errors in time estimation (Trojano, Caccavale, De Bellis, & Crisci, ).…”

Section: Introductionmentioning

confidence: 99%

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Does the insula contribute to emotion‐related distortion of time? A neuropsychological approach

Mella

Bourgeois

Perren

et al. 2018

Human Brain Mapping

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The literature points to a large distributed brain network involved in the estimation of time.Among these regions, the role of the insular cortex is still poorly understood. At the confluence of emotional, interoceptive, and environmental signals, this brain structure has been proposed to underlie awareness of the passage of time and emotion related time dilation. Yet, this assumption has not been tested so far. This study aimed at exploring how a lesion of the insula affects subjective duration, either in an emotional context or in a non-emotional context.Twenty-one patients with a stroke affecting the insula, either left or right, were studied for their perception of sub and supra second durations. A verbal estimation task and a temporal bisection task were used with either pure tones or neutral and emotional sounds lasting between 300 and 1500 ms and presented monaurally. Results revealed that patients with a right insular lesion, showed less temporal sensitivity than both control participants and patients with a left insular lesion. Unexpectedly, emotional effects were similar in patients and control participants. Altogether, these results suggest a specific role of the right insula in the discrimination of durations, but not in emotion related temporal distortion. In addition, an ear × emotion interaction in control participants suggests that temporal processing of positive and negative sounds may be lateralized in the brain. K E Y W O R D S emotion, insula, time estimation

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Does the insula contribute to emotion‐related distortion of time? A neuropsychological approach

Mella

Bourgeois

Perren

et al. 2018

Human Brain Mapping

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“…Activations in these two regions have repeatedly been documented in the literature on time perception [Ferrandez et al, ; Lewis and Miall, ; Nenadic et al, ; Pouthas et al, ; Rao et al, ], preferentially on the right hemisphere [Kosillo and Smith, ]. Furthermore, disturbance in temporal processing has recently been reported following lesion in the right IFC [Gooch et al, ] or in the right AIC/IFC region [Monfort et al, ]. The significance of the connection between this brain locus and time processing, however, remains unclear: it has been proposed to be involved in the representation of temporal information in memory [Pouthas et al, ], in the recovery of encoded durations from memory [Lewis and Miall, ], as well as in intertemporal decisions [Wittmann et al, ].…”

Section: Discussionmentioning

confidence: 97%

“…This view has recently changed following the divulgation of a number of brain imaging studies regularly reporting the participation of the IFC, usually in association with the anterior insular cortex (AIC) in a diversity of timing tasks [Kosillo and Smith, , for review]. In addition, two recent studies reported disturbance in temporal processing following lesions in the right IFC [Gooch et al, ] or in the right AIC/IFC region [Monfort et al, ]. In one particularly instructive fMRI study [Livesey et al, ], participants had to execute two nearly identical experiments, both consisting in comparing either the duration or the color of two successive, flickering stimuli—the same in the two tasks—but differing in the difficulty of the control (color) task.…”

Section: Introductionmentioning

confidence: 99%

fMRI identifies the right inferior frontal cortex as the brain region where time interval processing is altered by negative emotional arousal

Pfeuty

Dilharreguy

Gerlier

et al. 2014

Human Brain Mapping

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The reason why human beings are inclined to overestimate the duration of highly arousing negative events remains enigmatic. The issue about what neurocognitive mechanisms and neural structures support the connection between time perception and emotion was addressed here by an event-related neuroimaging study involving a localizer task, followed by the main experiment. The localizer task, in which participants had to categorize either the duration or the average color of visual stimuli aimed at identifying the neural structures constitutive of a duration-specific network. The aim of the main experiment, in which participants had to categorize the presentation time of either neutral or emotionally negative visual stimuli, was to unmask which parts of the previously identified duration-specific network are sensitive to emotionally negative arousal. The duration-specific network that we uncovered from the localizer task comprised the cerebellum bilaterally as well as the orbitofrontal, the anterior cingulate, the anterior insular, and the inferior frontal cortices in the right hemisphere. Strikingly, the imaging data from the main experiment underscored that the right inferior frontal cortex (IFC) was the only region within the duration-specific network whose activity was increased in the face of emotionally negative pictures compared to neutral ones. Remarkably too, the extent of neural activation induced by emotionally negative pictures (compared to neutral ones) in this region correlated with a behavioral index reflecting the extent to which emotionally negative pictures were overestimated compared to neutral ones. The results are discussed in relation to recent models and studies suggesting that the right anterior insular cortex/IFC is of central importance in time perception.

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“…These activities require the skill to measure the elapsed time in several intervals [12], and involve multiple cognitive processes like attention, memory and decision making [47]. To assess this phenomenon, the most used procedure is interval timing [20,25,29,43] which studies how a time interval is perceived, represented and estimated in a range of seconds to minutes [12].…”

Section: Introductionmentioning

confidence: 99%

Subjective time estimation in Antarctica: The impact of extreme environments and isolation on a time production task

Tortello

Agostino

Folgueira³

et al. 2020

Neuroscience Letters

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Distortion of time interval reproduction in an epileptic patient with a focal lesion in the right anterior insular/inferior frontal cortices

Cited by 13 publications

References 68 publications

Does the insula contribute to emotion‐related distortion of time? A neuropsychological approach

Does the insula contribute to emotion‐related distortion of time? A neuropsychological approach

fMRI identifies the right inferior frontal cortex as the brain region where time interval processing is altered by negative emotional arousal

Subjective time estimation in Antarctica: The impact of extreme environments and isolation on a time production task

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