Distortion-product otoacoustic emissions and auditory brainstem responses sensitivity assessment in cisplatin-induced ototoxicity in rats

Freitas, Marcos Rabelo de; Silva, Viviane Carvalho da; Brito, Gerly Anne de Castro; Junior, Jose Valdir de Carvalho; Junior, Raimundo Martins Gomes; Ribeiro, Ronaldo de Albuquerque

doi:10.1016/s1808-8694(15)30483-3

Cited by 3 publications

(2 citation statements)

References 50 publications

(99 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their frequency specificity helps to identify the damages of certain areas of the cochlea [30]. Significant reductions in DPOAE amplitude after a cochlear injury have been detected in both animal and clinical studies [17,20,31,32]. In cochlear damage that may develop due to noise or ototoxicity, it can be demonstrated by detecting decreases in DPOAE amplitudes in the early period before any loss is found in pure tone audiometry [19,33].…”

Section: Discussionmentioning

confidence: 99%

Assessment of cochlear functions in hospitalized patients with SARS-CoV-2 infection

Yaslikaya¹,

Aghayarov²,

Yilmazer³

et al. 2022

Med-Science

View full text Add to dashboard Cite

SARS-CoV-2 infection intensely increases thromboembolic events and inflammation. The inner ear can be easily damaged as a result of circulatory disorders and inflammation. Therefore, SARS-CoV-2 may negatively affect the cochlea. Outer hairy cell damage in the inner ear is one of the first signs of sensorineural hearing loss. Otoacoustic emissions use is an effective, objective, and non-invasive method for early detection of hearing loss. Our study aims to determine whether the cochlea is affected in hospitalized patients with SARS-CoV-2 infection who did not need intensive care treatment by using Distortion product otoacoustic emission (DPOAE) measurements. This study was conducted on 26 hospitalized patients with SARS-CoV-2 infection (patient group) and 25 healthy volunteers (control group). DPOAE measurements were performed on all participants in an audiometric test room. The DP-grams were obtained between 498Hz and 10000Hz. The DPOAE measurements were compared between two groups. When evaluated as a cluster, DP1 and the SNR values were found to be significantly lower in the patient group at frequencies 498, 996, 2002, 7998, 10000 Hz and frequencies 498, 996, 2002, 4004, 6299Hz, respectively. When the right and left ears of the patient group were compared, DP1 and SNR values were found to be similar at all frequencies. SARS-CoV-2 infection can cause damage to the outer hair cells and the regions of the cochlea belonging to a wide range of frequencies according to our DPOAE measurements and due to the specific characteristics of the virus.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of cochlear functions in hospitalized patients with SARS-CoV-2 infection

Yaslikaya¹,

Aghayarov²,

Yilmazer³

et al. 2022

Med-Science

View full text Add to dashboard Cite

show abstract

“…Since DPOAE result from the activity of outer hair cells, and provide a quick, non-invasive and sensitive technique for evaluating the functional state of these cells, their study is useful for the evaluation of the experimental ototoxicity of cisplatin, and has been the most widely used method for functional assessment in experimental studies [ 73 , 74 ]. However, a comparative study of DPOAEs versus brainstem evoked response audiometry in rats that had received systemic cisplatin showed a higher sensitivity of ABR in detecting functional changes attributable to such ototoxicity [ 75 ].…”

Section: Functional Changes Due To Cisplatin Ototoxicitymentioning

confidence: 99%

Cisplatin-Induced Ototoxicity: Effects, Mechanisms and Protection Strategies

Callejo

Sedó-Cabezón

Juan

et al. 2015

Toxics

129

View full text Add to dashboard Cite

Cisplatin is a highly effective chemotherapeutic agent that is widely used to treat solid organ malignancies. However, serious side effects have been associated with its use, such as bilateral, progressive, irreversible, dose-dependent neurosensory hearing loss. Current evidence indicates that cisplatin triggers the production of reactive oxygen species in target tissues in the inner ear. A variety of agents that protect against cisplatin-induced ototoxicity have been successfully tested in cell culture and animal models. However, many of them interfere with the therapeutic effect of cisplatin, and therefore are not suitable for systemic administration in clinical practice. Consequently, local administration strategies, namely intratympanic administration, have been developed to achieve otoprotection, without reducing the antitumoral effect of cisplatin. While a considerable amount of pre-clinical information is available, clinical data on treatments to prevent cisplatin ototoxicity are only just beginning to appear. This review summarizes clinical and experimental studies of cisplatin ototoxicity, and focuses on understanding its toxicity mechanisms, clinical repercussions and prevention strategies.

show abstract

Assessment of the Effectiveness of Quercetin on Cisplatin-Induced Ototoxicity in Rats

Gündoğdu¹,

Erkan

Aydın

et al. 2019

Int Adv Otol

View full text Add to dashboard Cite

The Journal of International Advanced Otology (J Int Adv Otol) is an international, peer reviewed, open access publication that is fully sponsored and owned by the European Academy of Otology and Neurotology and the Politzer Society. The journal is published triannually in April, August, and December and its publication language is English. The scope of the Journal is limited with otology, neurotology, audiology (excluding linguistics) and skull base medicine. The Journal of International Advanced Otology aims to publish manuscripts at the highest clinical and scientific level. J Int Adv Otol publishes original articles in the form of clinical and basic research, review articles, short reports and a limited number of case reports. Controversial patient discussions, communications on emerging technology, and historical issues will also be considered for publication. Target audience of J Int Adv Otol includes physicians and academics who work in the fields of otology, neurotology, audiology and skull base medicine.

show abstract

Distortion-product otoacoustic emissions and auditory brainstem responses sensitivity assessment in cisplatin-induced ototoxicity in rats

Cited by 3 publications

References 50 publications

Assessment of cochlear functions in hospitalized patients with SARS-CoV-2 infection

Assessment of cochlear functions in hospitalized patients with SARS-CoV-2 infection

Cisplatin-Induced Ototoxicity: Effects, Mechanisms and Protection Strategies

Assessment of the Effectiveness of Quercetin on Cisplatin-Induced Ototoxicity in Rats

Contact Info

Product

Resources

About