Distortion-Product Otoacoustic Emissions in Schoolchildren: Effects of Ear Asymmetry, Handedness, and Gender

Keogh, Tegan; Kei, Joseph; Driscoll, Carlie; Smyth, Veronica

doi:10.1055/s-0042-1745641

Cited by 18 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In crude analyses, the positively skewed PCB serum concentration distribution was categorized into tertiles. Regarding side and gender differences in ear functions − , the auditory outcomes were analyzed separately for left and right ears. For multivariate analysis, a linear model was applied for each ear side adjusted for gender, age (days) and examination site with OAEs being the dependent variable.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Serum PCB Concentrations and Cochlear Function in 12-Year-Old Children

Trnovec

Šovčíková

Pavlovčinová

et al. 2009

Environ. Sci. Technol.

View full text Add to dashboard Cite

Experimental evidence from animals indicates that exposure to polychlorinated biphenyls (PCBs) causes deterioration of the outer hair cells (OHCs) of the cochlea. To test this hypothesis in humans, we measured serum PCB concentrations in 574 12-year-old children residing in three districts in the Slovak Republic using high-resolution gas chromatography with micro-electron capture detection. As a marker of cochlear status, we measured transient evoked (TE) and distortion product (DP) otoacoustic emissions (OAEs), and assessed the cross-sectional association between serum PCBs and OAEs. Median total PCB concentrations were 352.8, 150.5, and 134.9 ng/g lipid in Michalovce, Svidnik, and Bratislava, respectively. In multivariate regression models where otoacoustic measures were modeled as a function of log (base 10) PCB concentrations with adjustment for gender, age, and site of examination, dioxin-like PCBs, non-dioxin-like PCBs and a PCB grouping targeting upregulation of hepatic uridine 5′-diphospho-glucuronosyltransferase were significantly associated with lower TEOAE powers at 1000 and 1500 Hz. At 1500 Hz, we observed a strong association with sum of PCBs and DL-PCBs, in the left ear only. The DPOAEs at 1000 Hz were associated with all 4 PCB groupings. The results of this study show that PCBs may affect the OHCs of the cochlea, a result consistent with findings from animal studies published to date.

show abstract

Section: Methodsmentioning

confidence: 99%

“…In crude analyses, the positively skewed PCB serum concentration distribution was categorized into tertiles. Regarding side and gender differences in ear functions (28)(29)(30)(31)(32)(33)(34)(35), the auditory outcomes were analyzed separately for left and right ears.…”

Section: Methodsmentioning

confidence: 99%

Serum PCB Concentrations and Cochlear Function in 12-Year-Old Children

Trnovec

Šovčíková

Pavlovčinová

et al. 2009

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

Click-Evoked Otoacoustic Emissions in Children and Adolescents with Gender Identity Disorder

et al. 2014

View full text Add to dashboard Cite

Click-evoked otoacoustic emissions (CEOAEs) are echo-like sounds that are produced by the inner ear in response to click-stimuli. CEOAEs generally have a higher amplitude in women compared to men and neonates already show a similar sex difference in CEOAEs. Weaker responses in males are proposed to originate from elevated levels of testosterone during perinatal sexual differentiation. Therefore, CEOAEs may be usedas a retrospective indicator of someone's perinatal androgen environment. Individuals diagnosed with Gender Identity Disorder (GID), according to DSM-IV-TR, are characterized by a strong identification with the other gender and discomfort about their natal sex. Although the etiology of GID is far from established, itishypothesizedthat atypicallevels of sexsteroids during a critical period of sexual differentiation of the brain might play a role. In the present study, we compared CEOAEs in treatmentnaïve children and adolescents with early-onset GID (24 natal boys, 23 natal girls) and control subjects (65 boys, 62 girls). We replicated the sex difference in CEOAE response amplitude in the control group. This sex difference, however, was not present in the GID groups. Boys with GID showed stronger, more female-typical CEOAEs whereas girls with GID did not differ in emissionstrengthcomparedtocontrolgirls.Basedontheassumption that CEOAE amplitude can be seen as an index of relative androgen exposure,our results provide some evidence for the idea that boys with GID may have been exposed to lower amounts of androgen during early development in comparison to control boys.

show abstract

A Clinical Study of Effect of Hyperpyrexia on Otoacoustic Emissions in Children

Murthy¹,

Spandana²

2018

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Various degrees of sensory neural hearing loss can be seen in the progression of some hereditary periodic fever syndromes. Otoacoustic emission testing can help to establish the inner ear involvement at an early period of a periodic fever with a risk of hearing loss (Abdul Kadir et al. in J Int Adv Otol 9(2.79):08-11, 2014). Sensorineural hearing loss is the common most complication of bacterial meningitis in childhood (Richardson in Pediatrics 102(6):1364-1368, 1998). When present from birth, or acquired in the pre-school years, hearing loss of any degree, even mild hearing loss, interferes with speech and language development. In addition to obvious communication deficits, the consequences of hearing loss in children and adults include psychosocial problems, such as frustration, irritability, anxiety, the tendency to withdraw from social interactions, and even depression (Dhar and Hall in Otoacoustic emissions: principles, procedures, and protocols, Plural Publishing, San Diego, 2011). OAE are acoustic signals emitted from cochlea to the middle ear and into the external ear where they are recorded. Evoked OAE are undetectable when deafness is above 30-35 dB Sound pressure level (Biswas in Clinical audio-vestibulometry for otologists and neurologists, Bhalani Publishing House, Mumbai, 1995). OAEs permit early detection of inner ear abnormalities associated with a wide variety of diseases and disorders, including Alport syndrome etc. With early detection, the serious consequences of hearing loss can sometimes be prevented. With proper identification and diagnosis of hearing impairment, timely and effective management for the same can be taken. Data for this study was collected from children (5-14 years) attending the Department of Otorhinolaryngology and Paediatrics Out-patient departments in P.E.S.I.M.S.R, Kuppam. Among the study population 43 (57.3%) were male and 32 (42.7%) were females showing the slight male preponderance. study was done on children with temperature > 1000 F, children with temperature were screened with OAE, and OAE was recorded in same children once fever has subsided and results were compared. This is a new study where we compared same group of children with fever and once fever has subsided. In most other studies, study group was compared to the healthy control group. In our study, children with fever having abnormal FDP values at f1were 9, they reverted back to base line once fever has subsided. This shows that there is no much damage to inner ear at lower frequencies. Almost 47 abnormal FDP values at f2 reverted back to normal. At higher frequencies (f3 and f4), there is no much change in abnormal FDPs with fever and after fever has subsided, this shows that there is more damage to inner ear at higher frequencies. This study demonstrated that hyperpyrexia causes hearing loss in children with fever probably due to cochlear involvement. We conclude that OAE can be used as a screening tool in detecting hearing loss among children because the technique is simple, reproducible, not expensive...

show abstract

Distortion-Product Otoacoustic Emissions in Schoolchildren: Effects of Ear Asymmetry, Handedness, and Gender

Cited by 18 publications

References 36 publications

Serum PCB Concentrations and Cochlear Function in 12-Year-Old Children

Serum PCB Concentrations and Cochlear Function in 12-Year-Old Children

Click-Evoked Otoacoustic Emissions in Children and Adolescents with Gender Identity Disorder

A Clinical Study of Effect of Hyperpyrexia on Otoacoustic Emissions in Children

Contact Info

Product

Resources

About