Distractibility and Memory Deficits in Long-Term Survivors of Acute Lymphoblastic Leukemia

Goff, John R.; Anderson, H R; Cooper, Peter F.

doi:10.1097/00004703-198012000-00005

Cited by 87 publications

(34 citation statements)

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“…All of these deficits were correlated with imaging abnormalities. Other studies of ALL survivors have found specific deficits in measures of reaction time, processing speed, attention, concentration, and memory that cannot be explained solely on the basis of generally lowered intellectual ability [88,92,93]. The attention ability most affected in survivors of ALL appears to be sustained attention, which is defined as the ability to maintain a consistent state of behavioral vigilance and persistence for an extended period.…”

Section: Neurocognitive Impact Of Antileukemia Therapymentioning

confidence: 99%

“…The emerging consensus is that the substantial decline in IQ and academic achievement observed in childhood cancer survivors is the result of one or more cognitive-processing deficits involving attention, short-term memory, speed of processing, visuomotor coordination, or sequencing abilities [16,[87][88][89][90]. Some of the most convincing evidence for these specific deficits has come from the work of Brouwers et al [16,91], who conducted two studies using both neuropsychologic testing and CT or MR neuroimaging to evaluate long-term survivors of childhood ALL treated with chemotherapy and cranial irradiation.…”

Section: Neurocognitive Impact Of Antileukemia Therapymentioning

confidence: 99%

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Quantitative morphologic evaluation of magnetic resonance imaging during and after treatment of childhood leukemia

et al. 2007

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Introduction-Medical advances over the last several decades, including CNS prophylaxis, have greatly increased survival in children with leukemia. As survival rates have increased, clinicians and scientists have been afforded the opportunity to further develop treatments to improve the quality of life of survivors by minimizing the long-term adverse effects. When evaluating the effect of antileukemia therapy on the developing brain, magnetic resonance (MR) imaging has been the preferred modality because it quantifies morphologic changes objectively and noninvasively.

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Section: Neurocognitive Impact Of Antileukemia Therapymentioning

confidence: 99%

Section: Neurocognitive Impact Of Antileukemia Therapymentioning

confidence: 99%

Quantitative morphologic evaluation of magnetic resonance imaging during and after treatment of childhood leukemia

et al. 2007

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“…However, subsequent studies have identified significant defects, particularly in patients younger at the time of diagnosis who have shown more marked cognitive defects than older patients (Eiser, 1978;Eiser& Lansdown, 1977;Goff, Anderson, & Cooper, 1980;Meadows et al, 1981;Mos, Nannis, & Poplack, 1981). Most of these studies have used the Wechsler intelligence tests (Wechsler, 1955(Wechsler, , 1974 as the principal instruments of measurement.…”

Section: Introductionmentioning

confidence: 99%

Attentional deficits in Long-term survivors of childhood acute lymphoblastic leukemia (ALL)

Brouwers¹,

Riccardi²,

Poplack³

et al. 1984

Journal of Clinical Neuropsychology

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Simple alerted auditory reaction time (SRT) behavior with various foreperiods was investigated in a group of long-term survivors of childhood ALL who were in continuous first remission. As part of therapy, the patients had received cranial irradiation and intrathecal chemotherapy to prevent the development of central nervous system leukemia. The patients were divided into three groups on the basis of CT brain scan findings: (1) those with normal CT scans (n = 10); (2) those with evidence of cortical atrophy (n = 8), and (3) those with intracerebral calcifications (n = 5). The SRT results indicated significant differences between patients with normal and abnormal CT scans. Specifically, patients with abnormal scans reacted slower, and this latency was exaggerated by increasing the length of the warning interval. Furthermore, they reacted with larger variability which increased with the prolongation of testing. Moreover, the severity of impairment was related to the type of CT-scan abnormality: patients with calcifications performed more poorly than patients with evidence of atrophy. The present results revealed a strong correlation between the presence and type of CT-scan abnormalities and attentional performance in long-term survivors of childhood ALL.

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“…In contrast, sustained and shifting attention skills appear to be spared (Anderson et al, 2004a;Goff et al, 1980). Acute pathology is uncommon; however studies conducted postradiation demonstrate delayed subcortical pathology in these children (Kingma et al, 1993;Paakko et al, 1992).…”

Section: Acute Lymphoblastic Leukemia (All)mentioning

confidence: 99%

Comparing attentional skills in children with acquired and developmental central nervous system disorders

Anderson

2006

J. Inter. Neuropsych. Soc.

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Attentional impairments in children occur in the context of both developmental and acquired disorders involving the central nervous system (CNS) and may have implications for ongoing development, potentially impeding cognitive, educational, and behavioral functions. Using a continuous performance paradigm (CPT), this study compared attentional profiles of children with developmental and acquired conditions impacting on the CNS: (i) attention deficit-hyperactivity disorder (ADHD: n 5 27); (ii) moderate traumatic brain injury (TBI: n 5 41); (iii) acute lymphoblastic leukemia (n 5 31); and (iv) insulin-dependent diabetes mellitus (n 5 39). A healthy control group (n 5 46) was also examined. Groups were compared on measures of sustained attention, selective attention, and response inhibition. In addition, measures of performance variability and deterioration and processing speed were examined. Results showed that children with ADHD exhibited global and severe attentional impairments in contrast to all other groups. Children with moderate TBI displayed mild attentional difficulties, restricted to selective and sustained attention domains. In conclusion, although CPT parameters differentiated the ADHD group from all others, a disorder-specific profile was not observed. (JINS, 2006, 12, 519-531.)

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Distractibility and Memory Deficits in Long-Term Survivors of Acute Lymphoblastic Leukemia

Cited by 87 publications

References 0 publications

Quantitative morphologic evaluation of magnetic resonance imaging during and after treatment of childhood leukemia

Quantitative morphologic evaluation of magnetic resonance imaging during and after treatment of childhood leukemia

Attentional deficits in Long-term survivors of childhood acute lymphoblastic leukemia (ALL)

Comparing attentional skills in children with acquired and developmental central nervous system disorders

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