Distraction-suppression effect on osteosarcoma

Liu, Wei; He, Hongbo; Zhang, Can; Liu, Yu-Peng; Wan, Jun

doi:10.1016/j.mehy.2018.09.004

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…In cases in which the tumor is adjacent to the growth plate, Cho et al[7], Cañadell et al[8], and Betz et al[9] recommend applying an epiphyseal distraction; they use this as a simple distraction technique for separating the growth plate from the degenerative layers of cells, and not as a routine lengthening procedure. This procedure entails the possibility of regeneration and some potential suppression effect on the tumor[10]. In our case, we used this technique to ensure a safe surgical margin, which was confirmed by histological evaluation.…”

Section: Discussionmentioning

confidence: 91%

Epiphyseal distraction and hybrid reconstruction using polymethyl methacrylate construct combined with free non-vascularized fibular graft in pediatric patients with osteosarcoma around knee: A case report

Liang¹,

He²,

Zhang³

et al. 2019

WJCC

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BACKGROUNDIn children with osteosarcoma around the knee joint without epiphysis involvement, joint-sparing surgery seems to be an ideal way to retain knee joint function. However, there are two points of debate with regard to the technique: How to accurately achieve a safe surgical margin, and how to achieve intercalary reconstruction of the massive bone defect following resection of the tumor.CASE SUMMARYWe present the case of an 8-year-old girl with osteosarcoma of the distal femur without involvement of the epiphysis. Epiphyseal distraction was applied to separate the epiphysis and metaphysis, and this provided a safe surgical margin. The massive bone defect was reconstructed with a custom-made antibiotic-loaded polymethyl methacrylate (PMMA) construct combined with a free non-vascularized fibular graft. Six months after surgery, bone union between the autograft and host bone was confirmed in both the proximal and distal femur by computer tomography (CT) examination. Moreover, considerable callus formation was found around the PMMA construct. After 28 mo of follow-up, there was no sign of recurrence or metastasis. The patient could walk without any aid and carry out her daily life activities satisfactorily.CONCLUSIONIn cases of osteosarcoma without epiphysis involvement, epiphyseal distraction can be easily applied to obtain a safe margin. Hybrid reconstruction with an antibiotic-loaded PMMA construct combined with a free non-vascularized fibular graft has the advantages of being easy to manufacture, less time-consuming to place, and less likely to get infected, while also ensuring bone union. Our case provides an alternative technique for biological reconstruction after joint-sparing surgery in patients with osteosarcoma around the knee without epiphyseal involvement.

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Section: Discussionmentioning

confidence: 91%

Epiphyseal distraction and hybrid reconstruction using polymethyl methacrylate construct combined with free non-vascularized fibular graft in pediatric patients with osteosarcoma around knee: A case report

Liang¹,

He²,

Zhang³

et al. 2019

WJCC

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Construction and evaluation of a folate-mediated adriamycin phosphorene thermosensitive hydrogel delivery system against osteosarcoma

Zhang,

Yang,

Chen

et al. 2024

Applied Materials Today

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On investigation of flexural, morphological, and shape memory properties for 3D printed PLA-PVDF NFs-PLA interleave composite structures for smart gripper applications

Thakur,

Singh,

Kumar

2023

Journal of Thermoplastic Composite Materials

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In the present study, the flexural, morphological, and shape memory properties of polylactic acid (PLA) matrix sandwiched with polyvinylidene difluoride (PVDF) Nanofibers (NFs) interleave composite structures have been investigated for applications of 4D printing such as smart grippers, and smart actuators. Firstly, an electrospinning process was carried out to form a PVDF NFs mat (thickness: 0.10–0.20 mm) under a flow rate of 3 µL/sec, an applied voltage of 12 kV, and a TCD of 100 mm. Further, the PVDF NFs mat was deposited in between the PLA layers, primed through fused filament fabrication (FFF) based 3D printing to manufacture the PLA-PVDF NFs-PLA based structures. In the next stage, the flexural properties were investigated for manufactured composite structures. The results highlight that the flexural strength of the composites was enhanced by 6.47% as compared to PLA. Results of the study are supported by a scanning electron microscope (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR), V-I, V-R, and shape memory analysis. The finding of the study suggests that composite structures primed by higher mat thickness and zig-zag infill pattern have resulted in higher electrical resistance and better shape memory effect. However, increasing the voltage in the composite structure having higher mat thickness with a zig-zag fill pattern has resulted in a higher resistance drop.

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Distraction-suppression effect on osteosarcoma

Cited by 4 publications

References 18 publications

Epiphyseal distraction and hybrid reconstruction using polymethyl methacrylate construct combined with free non-vascularized fibular graft in pediatric patients with osteosarcoma around knee: A case report

Epiphyseal distraction and hybrid reconstruction using polymethyl methacrylate construct combined with free non-vascularized fibular graft in pediatric patients with osteosarcoma around knee: A case report

Construction and evaluation of a folate-mediated adriamycin phosphorene thermosensitive hydrogel delivery system against osteosarcoma

On investigation of flexural, morphological, and shape memory properties for 3D printed PLA-PVDF NFs-PLA interleave composite structures for smart gripper applications

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