The Internet of Things (IoT) is an information carrier based on network communication, and it can make all general physical objects which can be independently addressed from an interconnected network. Controller Area Network (CAN) is a kind of serial communication network which can effectively support distributed control or real-time control. This paper proposes the design of an IoT-oriented universal CAN bus. In order to build a complete CAN communication simulation model, message sending and message receiving models are constructed, respectively. The simulation experiment proves that the IoT-oriented network communication model designed in this paper not only has low power consumption, but it can also solve the front-end compatibility problems caused by different communication protocols.