Abstract:In this study, a radial basis function (RBF) neural network with three-layer feed forward architecture was developed to effectively predict the viscosity ratio of different ethylene glycol/water based nanofluids. A total of 216 experimental data involving CuO, TiO 2 , SiO 2 , and SiC nanoparticles were collected from the published literature to train and test the RBF neural network. The parameters including temperature, nanoparticle properties (size, volume fraction, and density), and viscosity of the base fluid were selected as the input variables of the RBF neural network. The investigations demonstrated that the viscosity ratio predicted by the RBF neural network agreed well with the experimental data. The root mean squared error (RMSE), mean absolute percentage error (MAPE), sum of squared error (SSE), and statistical coefficient of multiple determination (R 2 ) were respectively 0.04615, 2.12738%, 0.46007, and 0.99925 for the total samples when the Spread was 0.3. In addition, the RBF neural network had a better ability for predicting the viscosity ratio of nanofluids than the typical Batchelor model and Chen model, and the prediction performance of RBF neural networks were affected by the size of the data set.