The paper introduces a robust adaptive fault-tolerant control system for the six-degree-of-freedom (six-DOF) dynamics of quadrotor unmanned aerial vehicles (UAVs), incorporating disturbances and abrupt actuator faults to represent real-world conditions. The proposed control scheme employs robust control terms to manage unknown disturbances. However, robust control performance may degrade due to sudden fault impacts. To handle this issue, we introduce adaptive laws to ensure continuous adaptation. The control architecture ensures the tracking system’s stability by combining robust control using sliding-mode control (SMC) with adaptive control developed using the certainty equivalence principle. The sliding-surface error limits the adaptive laws, in which the convergence of estimated parameters to the actual unknown variables is not required as they fully rely on the convergence of the tracking error. We provide rigorous mathematics to validate the proposed control design. Furthermore, we conduct numerical simulations for a quadrotor UAV to showcase the effectiveness of the proposed scheme. The results demonstrate the efficacy of the proposed design in handling external disturbances and abrupt actuator faults.