Distribution and accumulation of &lt;sup&gt;177&lt;/sup&gt;Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice

Hue, Jin Joo; Lee, Hu-Jang; Nam, Sang Yoon; Kim, Jong-Soo; Lee, Beom Jun; Yun, Young Won

doi:10.14405/kjvr.2015.55.1.57

Korean Journal of Veterinary Research

2015

DOI: 10.14405/kjvr.2015.55.1.57

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Distribution and accumulation of <sup>177</sup>Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice

Jin Joo Hue¹,

Hu-Jang Lee²,

Sang Yoon Nam³

et al.

Abstract: : To investigate kinetics of free 177 Lu and 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of 5 µCi/ mouse or 15 mg/kg body weight, respectively. Free 177Lu radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection.

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Cited by 3 publications

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Magnetic Resonance Imaging‐Guided Drug Delivery to Breast Cancer Stem‐Like Cells

Sun

Kim

Kang

et al. 2018

Adv Healthcare Materials

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The feasibility of detecting breast cancer stem-like cells (BCSCs) with magnetic resonance imaging using extradomain-B of fibronectin (EDB-FN)-specific peptide (APT )-conjugated thermally cross-linked superparamagnetic iron oxide nanoparticles (APT -TCL-SPIONs) is previously demonstrated. Here, doxorubicin (Dox)-loaded APT -TCL-SPIONs (Dox@APT -TCL-SPIONs) are generated and their theranostic ability in a BCSC xenograft mouse model is assessed. The Dox@APT -TCL-SPIONs enable more efficient delivery of Dox to tumors than nontargeted Dox@TCL-SPIONs. Much greater inhibition of BCSC tumor growth is observed after treatment with the Dox@APT -TCL-SPIONs than with either Dox@TCL-SPIONs or free Dox. Hypointense signals are observed in the majority of the mice in postcontrast but not precontrast T2*-weighted MR images of tumors 7 days after treatment with Dox@APT -TCL-SPIONs. An inverse correlation is observed between signal intensity and both EDB-FN expression and response to chemotherapy. The data indicate Dox@APT -TCL-SPIONs can detect BCSCs within tumors by targeting EDB-FN-expressing cells. These nanoparticles thus have theranostic potential in breast cancer.

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Magnetic Resonance Imaging‐Guided Drug Delivery to Breast Cancer Stem‐Like Cells

Sun

Kim

Kang

et al. 2018

Adv Healthcare Materials

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Interaction of Size-Tailored PEGylated Iron Oxide Nanoparticles with Lipid Membranes and Cells

Gal

Lassenberger

Herrero-Nogareda

et al. 2017

ACS Biomater. Sci. Eng.

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Targeted nanomedicine builds on the concept that nanoparticles can be directed to specific tissues while remaining inert to others organs. Many studies have been performed on the synthesis and cellular interactions of core− shell nanoparticles, in which a functional inorganic core is coated with a biocompatible polymer layer that should reduce nonspecific uptake and cytotoxicity. However, work is lacking that relates structural parameters of the core−shell structure and colloidal properties directly to interactions with cell membranes and further correlates these interactions to cell uptake. We have synthesized monodisperse (SD < 10%), single-crystalline, and superparamagnetic iron oxide nanoparticles (SPION) of different core size (3−8 nm) that are densely grafted with nitrodopamine-poly(ethylene glycol) (NDA-PEG(5 kDa)) brushes. We investigated the interactions of the PEGylated SPION with biomimetic membranes and cancer and kidney cells. It is shown that a dense homogeneous PEG shell suppresses membrane interactions and cell uptake but that nanoparticle curvature can influence membrane interactions for similarly grafted nanoparticles. Weak adsorption to anionic lipid membranes is shown to correlate with eukaryote cell uptake and is attributed to double-layer interactions without direct membrane penetration. This attraction is strongly suppressed during physiological conditions and leads to unprecedented low cell uptake and full cell viability when compared to those of traditional dextran-coated SPION. Less curved (larger core) PEGylated SPION show weaker membrane adsorption and lower cell uptake due to effectively denser shells. These results provide a better understanding of design criteria for core−shell nanoparticles in terms of avoiding nonspecific uptake by cells, reducing toxicity, and increasing circulation time.

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Translating Nanomedicine to Comparative Oncology—the Case for Combining Zinc Oxide Nanomaterials with Nucleic Acid Therapeutic and Protein Delivery for Treating Metastatic Cancer

Delong

Cheng

Pearson

et al. 2019

J Pharmacol Exp Ther

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The unique anticancer, biochemical, and immunologic properties of nanomaterials are becoming a new tool in biomedical research. Their translation into the clinic promises a new wave of targeted therapies. One nanomaterial of particular interest are zinc oxide (ZnO) nanoparticles (NPs), which has distinct mechanisms of anticancer activity including unique surface, induction of reactive oxygen species, lipid oxidation, pH, and also ionic gradients within cancer cells and the tumor microenvironment. It is recognized that ZnO NPs can serve as a direct enzyme inhibitor. Significantly, ZnO NPs inhibit extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) associated with melanoma progression, drug resistance, and metastasis. Indeed, direct intratumoral injection of ZnO NPs or a complex of ZnO with RNA significantly suppresses ERK and AKT phosphorylation. These data suggest ZnO NPs and their complexes or conjugates with nucleic acid therapeutic or anticancer protein may represent a potential new strategy for the treatment of metastatic melanoma, and potentially other cancers. This review focuses on the anticancer mechanisms of ZnO NPs and what is currently known about its biochemical effects on melanoma, biologic activity, and pharmacokinetics in rodents and its potential for translation into large animal, spontaneously developing models of melanoma and other cancers, which represent models of comparative oncology.

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Distribution and accumulation of <sup>177</sup>Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice

Cited by 3 publications

References 16 publications

Magnetic Resonance Imaging‐Guided Drug Delivery to Breast Cancer Stem‐Like Cells

Magnetic Resonance Imaging‐Guided Drug Delivery to Breast Cancer Stem‐Like Cells

Interaction of Size-Tailored PEGylated Iron Oxide Nanoparticles with Lipid Membranes and Cells

Translating Nanomedicine to Comparative Oncology—the Case for Combining Zinc Oxide Nanomaterials with Nucleic Acid Therapeutic and Protein Delivery for Treating Metastatic Cancer

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