Distribution and antibacterial susceptibility of macrolide resistance genotypes in Streptococcus pneumoniae: PROTEKT Year 5 (2003–2004)

Farrell, David J.; Couturier, Catherine; Hryniewicz, Waleria

doi:10.1016/j.ijantimicag.2007.10.022

Cited by 56 publications

(61 citation statements)

References 14 publications

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“…Our results are in accordance with previous studies concerning Finland (21,43,48). The macrolide resistance gene distribution in Finland is more comparable with that of North America and Scotland than with that of continental Europe (21,60).…”

Section: Discussionsupporting

confidence: 93%

“…The highest antimicrobial nonsusceptibility prevalences were seen among pneumococci isolated from children less than 15 years old, particularly those less than 2 years of age. This may be explained by the high consumption of antimicrobials among young children, compared to other age groups (4), and is in accordance with studies from other countries (18,21).…”

Section: Discussionsupporting

confidence: 87%

“…Compared to that for the years 1999 to 2000, there was a fivefold increase in ERY nonsusceptibility (43). In Europe, ERY resistance prevalences similar to that for Finland (20 to 30%) have been reported from Germany, the United Kingdom, and Switzerland (21), while countries with low macrolide resistance prevalences (Ͻ11%) include Austria, the Czech Republic, Denmark, Norway, Portugal, Sweden, and The Netherlands (2,21,49,54). Globally, the highest ERY resistance prevalences are found in the Far East (ϳ80%) and the lowest in Latin America (ϳ15%) (23).…”

Section: Discussionmentioning

confidence: 93%

“…All five ST271 and ST2917 isolates were derived from children aged 2 years or less. Dual macrolide resistance is reportedly significantly more frequent among isolates derived from 0-to 2-year-olds than from the other age groups (21).…”

Section: Discussionmentioning

confidence: 93%

See 3 more Smart Citations

Temporal Trends of Antimicrobial Resistance and Clonality of Invasive Streptococcus pneumoniae Isolates in Finland, 2002 to 2006

Siira

Rantala

Jalava

et al. 2009

Antimicrob Agents Chemother

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The antimicrobial resistance of Streptococcus pneumoniae, or pneumococcus, is a growing global problem. In our study, 3,571 invasive pneumococcal isolates, recovered from blood and cerebrospinal fluid samples from patients in Finland between the years 2002 and 2006, showed an increase in erythromycin nonsusceptibility from 16% to 28% (P < 0.0001) over the 5-year study period, as well as a doubling of penicillin nonsusceptibility from 8% to 16% (P < 0.0001). Erythromycin nonsusceptibility increased especially in isolates derived from 0-to 2-year-old children and was 46% for this age group in 2006. Although multiresistance, defined as nonsusceptibility to penicillin, erythromycin, and tetracycline, was fairly rare (5.1% in 2006), 38% of the erythromycin-nonsusceptible isolates were also penicillin nonsusceptible, while 74% of the penicillin-nonsusceptible isolates were nonsusceptible to erythromycin. In contrast to the situation in continental Europe, but mirroring that in North America, the most frequent macrolide resistance determinant carried by 56% of the tested macrolide-resistant pneumococci was the mef gene. Serotypes 14, 9V, 19A, 6B, and 19F were most frequently nonsusceptible to erythromycin or penicillin. The penicillin-resistant invasive isolates (n ‫؍‬ 88) were genotyped by multilocus sequence typing, which revealed the presence of 25 sequence types, 9 of which were novel. The majority of the isolates were related to one of several globally disseminated penicillin-or multiresistant clones, most importantly the rlrA adhesion pilus carrying clones Spain 9V ST156 and Taiwan 19F ST236. The penicillin-resistant pneumococcal population in Finland is therefore a combination of internationally recognized genotypes as well as novel ones.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

See 2 more Smart Citations

Temporal Trends of Antimicrobial Resistance and Clonality of Invasive Streptococcus pneumoniae Isolates in Finland, 2002 to 2006

Siira

Rantala

Jalava

et al. 2009

Antimicrob Agents Chemother

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show abstract

“…A global international surveillance project (PROTEKT, 2003(PROTEKT, to 2004 found that the overall rate of erythromycin resistance was 37.2%, although significant geographical differences in these rates were observed (11). MR in S. pneumoniae is mediated mainly by two major mechanisms, namely, target site modification [encoded by the erm(B) gene and related to the MLS B phenotype] and an efflux pump (encoded by mef genes and related to the M phenotype).…”

mentioning

confidence: 99%

Serotype and Genotype Replacement among Macrolide-Resistant Invasive Pneumococci in Adults: Mechanisms of Resistance and Association with Different Transposons

et al. 2010

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Evaluation of resistance mechanisms and serotype and genotype distributions of macrolide-resistant strains in clinical isolates of Streptococcus pneumonia in Aydın, Turkey

Telli

Eyigör

Gültekin

et al. 2011

Journal of Infection and Chemotherapy

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Distribution and antibacterial susceptibility of macrolide resistance genotypes in Streptococcus pneumoniae: PROTEKT Year 5 (2003–2004)

Cited by 56 publications

References 14 publications

Temporal Trends of Antimicrobial Resistance and Clonality of Invasive Streptococcus pneumoniae Isolates in Finland, 2002 to 2006

Temporal Trends of Antimicrobial Resistance and Clonality of Invasive Streptococcus pneumoniae Isolates in Finland, 2002 to 2006

Serotype and Genotype Replacement among Macrolide-Resistant Invasive Pneumococci in Adults: Mechanisms of Resistance and Association with Different Transposons

Evaluation of resistance mechanisms and serotype and genotype distributions of macrolide-resistant strains in clinical isolates of Streptococcus pneumonia in Aydın, Turkey

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