Distribution and characterization of diazepam binding inhibitor (DBI) in peripheral tissues of rat

Bovolin, Patrizia; Schlichting, Joyce L.; Miyata, Masakazu; Ferrarese, Carlo; Guidotti, Alessandro; Alho, Hannu

doi:10.1016/0167-0115(90)90089-f

Cited by 141 publications

(73 citation statements)

References 23 publications

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“…DBI can stimulate in vivo steroidogenesis via binding to peripheral BZR resulting in increased pregnenolone synthesis (Besman et al 1989, Papadopoulos et al 1991. DBI expression in the rat ovary has been reported previously (Bovolin et al 1990, Toranzo et al 1994). In the current study, DBI mRNA was increased in both the GC and TC compartments of bovine preovulatory follicles in response to an ovulatory stimulus.…”

Section: Discussionmentioning

confidence: 95%

“…ADAM10 belongs to the ADAM family of transmembrane proteinases linked to processing of EGF family ligands (Blobel 2005) that mediate LH action (cumulus expansion, oocyte maturation, ovulation) during the periovulatory period in mice (Park et al 2004, Conti et al 2006. DBI is present in the rat ovary (Bovolin et al 1990, Toranzo et al 1994 and is a known stimulator of steroidogenesis/pregnenolone biosynthesis (Besman et al 1989, Papadopoulos et al 1991. CD36 is a multifunctional scavenger receptor that binds known autocrine growth factors that can regulate cell growth, adhesion, and angiogenesis (Febbraio et al 2001).…”

Section: Gonadotropin Surge Induced Up-regulation Of Gene Expression mentioning

confidence: 99%

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Gene expression profiling of bovine preovulatory follicles: gonadotropin surge and prostanoid-dependent up-regulation of genes potentially linked to the ovulatory process

Jimenez-Krassel

Ireland

et al. 2009

Reproduction

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The molecular mechanisms of ovulation and luteinization have not been well established, partially due to lack of a comprehensive understanding of functionally significant genes up-regulated in response to an ovulatory stimulus and the signaling pathways involved. In the present study, transcripts increased in bovine preovulatory follicles following a GnRH-induced LH surge were identified using microarray technology. Increased expression of 368 and 878 genes was detected at 12 (368 genes) and 20 h (878 genes) following GnRH injection. The temporal, cell specific and prostanoid-dependent regulation of selected genes (ADAM10, DBI, CD36, MTSS1, TFG, and RABGAP1) identified from microarray studies and related genes (ADAM17 and AREG) of potential significance were also investigated. Expression of mRNA for DBI and CD36 was simultaneously up-regulated in theca and granulosa cells (GC) following the LH surge, whereas temporal regulation of ADAM10, MTSS1, TFG, and RABGAP1 was distinct in the two cell compartments and increased granulosa TFG and RABGAP1 mRNA were prostanoid dependent. AREG mRNA was increased in theca and GCs at 12 and 24 h following GnRH injection. ADAM17 mRNA was increased in theca, but reduced in GCs 24 h following GnRH injection. The increased ADAM17 and AREG mRNA were prostanoid dependent. ADAM10 and ADAM17 protein were increased specifically in the apex but not the base of preovulatory follicles and the increase in ADAM17 was prostanoid dependent. Results reveal novel information on the regulation of preovulatory gene expression and suggest a potential functional role for ADAM10 and ADAM17 proteins in the region of follicle rupture.

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Section: Discussionmentioning

confidence: 95%

Section: Gonadotropin Surge Induced Up-regulation Of Gene Expression mentioning

confidence: 99%

Gene expression profiling of bovine preovulatory follicles: gonadotropin surge and prostanoid-dependent up-regulation of genes potentially linked to the ovulatory process

Jimenez-Krassel

Ireland

et al. 2009

Reproduction

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“…Adrenal activation by the sympathetic nervous system may prove to be critical [151]. One possible regulator of the adrenarchespecific stimulation of adrenal androgen production may be the polypeptide diazepam binding inhibitor (DBI), a presumed endogenous GABA A modulator that has been shown to facilitate ACTH-stimulated steroidogenesis in the adrenals of laboratory animals [43,53]. The ontogeny of DBI and its potential relationship to adrenarche in humans, however, have yet to be explored.…”

Section: Adrenarchementioning

confidence: 99%

The adolescent brain and age-related behavioral manifestations

Spear

2000

Neuroscience & Biobehavioral Reviews

4,738

110

4,301

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To successfully negotiate the developmental transition between youth and adulthood, adolescents must maneuver this often stressful period while acquiring skills necessary for independence. Certain behavioral features, including age-related increases in social behavior and risk-taking/novelty-seeking, are common among adolescents of diverse mammalian species and may aid in this process. Reduced positive incentive values from stimuli may lead adolescents to pursue new appetitive reinforcers through drug use and other risk-taking behaviors, with their relative insensitivity to drugs supporting comparatively greater per occasion use. Pubertal increases in gonadal hormones are a hallmark of adolescence, although there is little evidence for a simple association of these hormones with behavioral change during adolescence. Prominent developmental transformations are seen in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems. Developmental changes in these stressor-sensitive regions, which are critical for attributing incentive salience to drugs and other stimuli, likely contribute to the unique characteristics of adolescence. ᭧

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“…ACBP is a widely distributed cytosolic protein of molecular mass 10 kDa that has been found in all eukaryotes tested, from plants to humans [130], and has been identified in liver, adipose tissue, kidney, heart, brain, intestine, skeletal muscle, mammary gland [111], erythrocytes [131] duodenum, testis, adrenal gland, ovary, lung and spleen [132,133]. Recently an ACBP isoform (endozepine-like peptide) was identified in mouse testes [134].…”

Section: Role Of Acbp In Acyl-coa Metabolism and Acyl-coa-mediated Cementioning

confidence: 99%

Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling

Færgeman¹,

Knudsen²

1997

Biochemical Journal

629

477

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The intracellular concentration of free unbound acyl-CoA esters is tightly controlled by feedback inhibition of the acyl-CoA synthetase and is buffered by specific acyl-CoA binding proteins. Excessive increases in the concentration are expected to be prevented by conversion into acylcarnitines or by hydrolysis by acyl-CoA hydrolases. Under normal physiological conditions the free cytosolic concentration of acyl-CoA esters will be in the low nanomolar range, and it is unlikely to exceed 200 nM under the most extreme conditions. The fact that acetyl-CoA carboxylase is active during fatty acid synthesis (Ki for acyl-CoA is 5 nM) indicates strongly that the free cytosolic acyl-CoA concentration is below 5 nM under these conditions. Only a limited number of the reported experiments on the effects of acyl-CoA on cellular functions and enzymes have been carried out at low physiological concentrations in the presence of the appropriate acyl-CoA-buffering binding proteins. Re-evaluation of many of the reported effects is therefore urgently required. However, the observations that the ryanodine-senstitive Ca2+-release channel is regulated by long-chain acyl-CoA esters in the presence of a molar excess of acyl-CoA binding protein and that acetyl-CoA carboxylase, the AMP kinase kinase and the Escherichia coli transcription factor FadR are affected by low nanomolar concentrations of acyl-CoA indicate that long-chain acyl-CoA esters can act as regulatory molecules in vivo. This view is further supported by the observation that fatty acids do not repress expression of acetyl-CoA carboxylase or Δ9-desaturase in yeast deficient in acyl-CoA synthetase.

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Distribution and characterization of diazepam binding inhibitor (DBI) in peripheral tissues of rat

Cited by 141 publications

References 23 publications

Gene expression profiling of bovine preovulatory follicles: gonadotropin surge and prostanoid-dependent up-regulation of genes potentially linked to the ovulatory process

Gene expression profiling of bovine preovulatory follicles: gonadotropin surge and prostanoid-dependent up-regulation of genes potentially linked to the ovulatory process

The adolescent brain and age-related behavioral manifestations

Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling

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